Semantic empowerment of Health Care and Life Science Applications

Amit Sheth

LSDIS lab, Computer Science Department, the University of Georgia Semagix, Inc.



















Organized by

Organizer: Amit Sheth



Health care practices and bioinformatics have already succeeded in utilizing database management, workflow and information retrieval technologies, which have provided syntactic search, heterogeneous data access and sharing, and limited forms of integration. We can realize more exciting potential of health care and life science if we have more automated ways for analysis leading to insight and discovery - to understand cellular components, molecular functions and biological processes, and more importantly complex interactions and interdependencies between them.  Similarly, applications of relevant knowledge (e.g., drug interactions) at the point of delivery can improve patient care and satisfaction, and reduce errors and help develop quality of measures.

This talks focuses on semantics enabled life sciences research and health care. After a brief review of successful efforts that have exploited ontologies, we will describe on-going collaborations of the LSDIS lab with biologists at UGA, and Athens Heart Center. We will first discuss a deployment and initial evaluation of an Active Semantic Electronic Medical Report system which has been operationally used for several months in a busy cardiology practice. Next we will discuss development of GlycO (an ontology for structure and function for Glycopeptides) and ProPreO (an ontology for capturing process and lifecycle information related to proteomic experiments) developed in collaboration with CCRC as part of the NCRR center ( particular, we will discuss, through examples and use cases covering:

  • new technical capabilities such as (a) those related to semantic annotation experimental scientific data, biomedical literature and web services, (b) relationship discovery from biomedical literature
  • new tools that provide semantic search, browsing and filtering capabilities to deal with large complex ontologies, and integrated display of knowledge bases and pathways, and
  • new analytical and discovery framework that would support discovery and analysis questions such as: "how does the glycosylation pattern of the cell change when it undergoes a physiological change, such as differentiation or transformation to a cancer cell?"

Biographical Sketch

About the Speaker: Amit Sheth directs the LSDIS lab and is a professor of Computer Science at the University of Georgia (UGA). He has started two successful companies (the latest is a Semantic Web company, Semagix, for which he now serves as the chief scientist) and his research has led to several commercial products and deployed applications. Prior to joining UGA in 1994, he was in R&D leadership positions at Honeywell, Unisys and Bellcore.

Prof. Sheth is an IEEE Fellow, the EIC of Intl. Journal on Semantic Web & Information Systems, and a Member of the W3C Advisory Committee. He has over 200 publications, given over 160 invited talks (including 24 keynotes), led (chair/co-chair) 25+ international workshops/conferences, been a member of 110+ PCs, and serves on 5 journal editorial board.

    Last update: April 12, 2006