PMID- 14725669 OWN - NLM STAT- completed DA - 20040116 DCOM- 20040202 IS - 1076-0512 VI - 29 IP - 12 DP - 2003 Dec TI - Metastatic eccrine porocarcinoma: a 5.6-year follow-up study of a patient treated with a combined therapeutic protocol. PG - 1227-32 AB - BACKGROUND: Metastatic eccrine porocarcinoma (EP) is an uncommon, malignant, and potentially lethal neoplasm that arises from the eccrine sweat glands. OBJECTIVE: To present the 5.6-year follow-up study of a male patient with metastatic EP, highlighting the widespread cutaneous involvement and the response to the treatment carried out. METHODS: We describe the evolution of the tumor and the combined therapy carried out and review the treatments employed in previously reported cases, comparing them with ours. RESULTS: The patient developed multiple cutaneous and regional lymph node metastases 15 months after surgical excision of the primary tumor. He was treated with prophylactic lymphadenectomy, radiotherapy, and oral isotretinoin, subsequently substituted by tegafur. We have not found evidence of distant metastases after a 5.6-year follow-up. CONCLUSIONS: The optimum treatment for metastatic EP is not standardized, and the results obtained to date were generally poor. In this context, we consider it of interest to highlight the response of our patient to the therapeutic regime employed, which may be advantageous in future cases of this rare tumor. AD - Department of Dermatology, Central University Hospital, University of Oviedo, C/Miguel de Unamuno no. 21, 3c, 33010 Oviedo, Spain. FAU - Gonzalez-Lopez, Marcos A AU - Gonzalez-Lopez MA FAU - Vazquez-Lopez, Francisco AU - Vazquez-Lopez F FAU - Soler, Tomas AU - Soler T FAU - Gomez-Diez, Santiago AU - Gomez-Diez S FAU - Garcia, Yolanda Hidalgo AU - Garcia YH FAU - Manjon, Jose A AU - Manjon JA FAU - Lopez-Escobar, Maria AU - Lopez-Escobar M FAU - Perez-Oliva, Narciso AU - Perez-Oliva N LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review Literature PL - United States TA - Dermatol Surg JID - 9504371 SB - IM MH - Acrospiroma, Eccrine/*pathology/*therapy MH - Aged MH - Combined Modality Therapy MH - Follow-Up Studies MH - Human MH - Male MH - Neoplasm Metastasis MH - Sweat Gland Neoplasms/*pathology/*therapy MH - Time Factors RF - 34 EDAT- 2004/01/17 05:00 MHDA- 2004/02/03 05:00 AID - 29393 [pii] PST - ppublish SO - Dermatol Surg 2003 Dec;29(12):1227-32. PMID- 14576644 OWN - NLM STAT- completed DA - 20031024 DCOM- 20031118 IS - 0190-9622 VI - 49 IP - 5 Suppl DP - 2003 Nov TI - Widespread metastatic eccrine porocarcinoma. PG - S252-4 AB - Eccrine porocarcinoma is a rare malignant sweat gland tumor arising from the acrosyringium. These lesions can show multiple epidermotropic metastases, however, systemic spread is rare. We describe the case of a 42-year-old African American man who presented in February 1998 with a lesion on the plantar surface of his right foot that was diagnosed as an eccrine porocarcinoma. Subsequently, during the next year, cutaneous metastases developed to his left shoulder and flank. Two years after his initial presentation, he was admitted with an esophageal mass and multiple gastric ulcers. Biopsy specimens of these lesions demonstrated metastatic eccrine porocarcinoma. Further evaluation revealed multiple metastases to lymph nodes, lungs, and brain. Histologic examination revealed nests of basaloid cells with eosinophilic cytoplasm and intracellular ductlike lumina lined by eosinophilic basement membranelike material. These ductular structures where highlighted by immunohistochemical stains for carcinoembryonic antigen, confirming their eccrine differentiation. There were mitotic figures and individual cell necrosis. Although rare, systemic metastases from an eccrine porocarcinoma must enter the differential diagnoses of a tumor mass in such patients. AD - Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA. rgoel@hsc.vcu.edu FAU - Goel, Rajat AU - Goel R FAU - Contos, Melissa J AU - Contos MJ FAU - Wallace, Michael L AU - Wallace ML LA - eng PT - Case Reports PT - Journal Article PL - United States TA - J Am Acad Dermatol JID - 7907132 SB - IM MH - Acrospiroma, Eccrine/*diagnosis/pathology/radiography MH - Adult MH - Brain Neoplasms/diagnosis/secondary MH - Diagnosis, Differential MH - Esophageal Neoplasms/diagnosis/secondary MH - Fatal Outcome MH - Foot Ulcer/diagnosis/pathology MH - Human MH - Liver Neoplasms/diagnosis/secondary MH - Lung Neoplasms/diagnosis/radiography/secondary MH - Lymphatic Metastasis MH - Male MH - Stomach Neoplasms/diagnosis/secondary MH - Sweat Gland Neoplasms/*diagnosis/pathology MH - Tomography, X-Ray Computed EDAT- 2003/10/25 05:00 MHDA- 2003/12/03 05:00 AID - 10.1016/S0190 [doi] AID - S0190962203004444 [pii] PST - ppublish SO - J Am Acad Dermatol 2003 Nov;49(5 Suppl):S252-4. PMID- 12974711 OWN - NLM STAT- completed DA - 20030916 DCOM- 20031112 LR - 20031114 IS - 1076-0512 VI - 29 IP - 10 DP - 2003 Oct TI - Pigmented eccrine poroma: a report of two cases and study with dermatoscopy. PG - 1076-9 AB - BACKGROUND: Most eccrine poromas are devoid of melanin pigmentation clinically and melanocytes on microscopic examination. Pigmented variant of eccrine poroma has been reported only sporadically. Dermatoscopy (epiluminescence microscopy) has recently proved to be a useful, noninvasive technique for the diagnosis of cutaneous pigmented lesions. However, detailed information about the pigmented variant of eccrine poroma is not available. METHOD: We report two additional cases of pigmented eccrine poroma and describe their dermatoscopic features. RESULT: The dermatoscopic features of pigmented poromas except the maple leaf-like structures and spoke-wheel areas were similar to those of pigmented basal cell carcinomas. CONCLUSION: Physicians therefore should be aware of the dermatoscopic differentiation between pigmented poromas and basal cell carcinomas. AD - Department of Dermatology, Chang Gung Memorial Hospital-Kaohsiung, Kaohsiung Hsien, Taiwan. FAU - Kuo, Hung-Wen AU - Kuo HW FAU - Ohara, Kuniaki AU - Ohara K LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Dermatol Surg JID - 9504371 SB - IM MH - Acrospiroma, Eccrine/*diagnosis MH - Aged MH - Aged, 80 and over MH - Carcinoma, Basal Cell/*diagnosis MH - Diagnosis, Differential MH - Female MH - Human MH - Male MH - Microscopy/*methods MH - Middle Aged MH - Skin MH - Skin Neoplasms/*diagnosis MH - Skin Pigmentation MH - Sweat Gland Neoplasms/diagnosis EDAT- 2003/09/17 05:00 MHDA- 2003/11/13 05:00 AID - 29308 [pii] PST - ppublish SO - Dermatol Surg 2003 Oct;29(10):1076-9. PMID- 12966513 OWN - NLM STAT- completed DA - 20030910 DCOM- 20040204 IS - 1043-3074 VI - 25 IP - 10 DP - 2003 Oct TI - Applicability of lymphoscintigraphy with sentinel node biopsy to eccrine carcinoma of the head and neck. PG - 879-82 AB - BACKGROUND: Eccrine carcinoma of the head and neck has the propensity to metastasize both to regional and distant sites. When associated with nodal metastasis, there is a high incidence of distant spread of disease, ultimately being associated with the death of the patient. Management of the patient with clinically negative nodes remains controversial. Although elective nodal dissection has been performed, the impact of this intervention remains indeterminate. This case series serves as a feasibility study for use of the technique of lymphoscintigraphy with sentinel node biopsy for eccrine carcinoma arising in the head and neck. METHODS: Two patients with eccrine carcinoma underwent sentinel node biopsy by way of the standard, three-part technique using lymphoscintigraphy, 1% isosulfan blue dye, and intraoperative use of the gamma probe. RESULTS: In each of these cases, the lymphoscintigram successfully identified sentinel lymph nodes. Intraoperative findings were significant for confirmation of sentinel nodes with the presence of blue dye in the lymph node. In one case, frozen section identified a positive sentinel lymph node, and the patient underwent definitive nodal dissection and postoperative radiotherapy. In the second case, immunohistochemistry as part of final pathology identified a single microscopic foci of metastatic eccrine carcinoma, for which the patient elected to receive definitive radiation therapy. CONCLUSIONS: This report documents the efficacy of lymphoscintigraphy with sentinel lymph node biopsy in identifying microscopic metastasis eccrine carcinoma in primary lesions arising in the head and neck. CI - Copyright 2003 Wiley Periodicals, Inc. AD - Albert Einstein College of Medicine, Bronx, New York, USA. FAU - Chang, Amy S AU - Chang AS FAU - Busam, Klaus AU - Busam K FAU - Kraus, Dennis H AU - Kraus DH LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Head Neck JID - 8902541 SB - IM MH - Acrospiroma, Eccrine/pathology/*radionuclide imaging/surgery MH - Adult MH - Aged MH - Female MH - Head and Neck Neoplasms/pathology/*radionuclide imaging/surgery MH - Human MH - Lymph Nodes/pathology/*radionuclide imaging/surgery MH - Lymphatic Metastasis MH - Male MH - *Sentinel Lymph Node Biopsy EDAT- 2003/09/11 05:00 MHDA- 2004/02/05 05:00 AID - 10.1002/hed.10300 [doi] PST - ppublish SO - Head Neck 2003 Oct;25(10):879-82. PMID- 12951728 OWN - NLM STAT- completed DA - 20030903 DCOM- 20031007 LR - 20031114 IS - 0028-2162 VI - 147 IP - 33 DP - 2003 Aug 16 TI - [Diagnostic image (152). A man with a swelling in the groin. Malignant eccrine poroma] PG - 1590 AB - A malignant eccrine poroma (porocarcinoma) was excised from the right groin of a 78-year-old man. AD - Afd. Chirurgie, Reinier de Graaf Groep, Reinier de Graafweg 3-11, 2625 AD Delft. keijzer@rdgg.nl FAU - Keijzer, R AU - Keijzer R FAU - Sastrowijoto, S H AU - Sastrowijoto SH FAU - Brakman, M AU - Brakman M FAU - van der Elst, M AU - van der Elst M LA - dut PT - Case Reports PT - Journal Article TT - Diagnose in beeld (152). Een man met een gezwel in de lies. Maligne eccrien poroom. PL - Netherlands TA - Ned Tijdschr Geneeskd JID - 0400770 SB - IM MH - Acrospiroma, Eccrine/*diagnosis/pathology/surgery MH - Aged MH - Eccrine Glands/pathology MH - English Abstract MH - Groin MH - Human MH - Male MH - Sweat Gland Neoplasms/*diagnosis/pathology/surgery EDAT- 2003/09/04 05:00 MHDA- 2003/10/08 05:00 PST - ppublish SO - Ned Tijdschr Geneeskd 2003 Aug 16;147(33):1590. PMID- 12927299 OWN - NLM STAT- completed DA - 20030820 DCOM- 20040114 IS - 0385-8146 VI - 30 IP - 3 DP - 2003 Aug TI - Malignant eccrine hidradenoma of neck causing acute heart failure. PG - 307-10 AB - Tumours of eccrine sweat glands are uncommon, with complex classification and different terms used even for the same tumour. Therefore, for practical purposes, it may be sufficient to differentiate between benign and malignant. Malignant eccrine hidradenoma has a predilection for head and neck, with high incidence of recurrence following surgical excision and also regional and distant metastases. We describe a case, which presented as a medical emergency with symptoms of severe anaemia and acute heart failure secondary to intermittent bleeding from a huge ulcerative neck lesion, which was subsequently diagnosed as eccrine hidradenocarcinoma. The tumour was successfully treated with complete surgical excision and reconstruction followed by radiotherapy. Two years postoperatively, the patient is very well with no sign of recurrence. AD - Department of Otolaryngology-Head and Neck Surgery, Barking, Havering and Redbridge Hospitals NHS Trust, Essex, UK. khalilhesham@hotmail.com FAU - Khalil, Hesham M B AU - Khalil HM FAU - Yusuf, Hafza AU - Yusuf H FAU - Kaddour, Hesham S AU - Kaddour HS LA - eng PT - Journal Article PL - Netherlands TA - Auris Nasus Larynx JID - 7708170 SB - IM MH - Acrospiroma, Eccrine/*complications/physiopathology/therapy MH - Acute Disease MH - Adenoma, Sweat Gland/*complications/physiopathology/therapy MH - Aged MH - Anemia/etiology MH - Emergencies MH - Heart Failure, Congestive/*etiology MH - Hemorrhage/complications/etiology MH - Human MH - Male MH - *Neck MH - Skin Ulcer/complications/*etiology MH - Tomography, X-Ray Computed EDAT- 2003/08/21 05:00 MHDA- 2004/01/15 05:00 AID - S0385814603000993 [pii] PST - ppublish SO - Auris Nasus Larynx 2003 Aug;30(3):307-10. PMID- 12828705 OWN - NLM STAT- completed DA - 20030627 DCOM- 20030904 LR - 20031114 IS - 1076-0512 VI - 29 IP - 7 DP - 2003 Jul TI - A case of porocarcinoma from pre-existing hidroacanthoma simplex: need of early excision for hidroacanthoma simplex? PG - 772-4 AB - BACKGROUND: Hidroacanthoma simplex (HAS) is an uncommon eccrine neoplasm of the skin. It is a benign neoplasm, but some cases of malignant change were reported in the literature. OBJECTIVE: To describe a rare case of porocarcinoma in a relatively short period from pre-existing HAS on the abdomen. METHODS: Wide local excision was performed on this neoplasm. RESULTS: There was no recurrence for 72 months after wide excision. CONCLUSION. : We recommend an early excision and careful attention in the case of HAS because of its potential malignant change. AD - Department of Dermatology, Pusan National University, Busan, Korea. FAU - Lee, Jae-Bong AU - Lee JB FAU - Oh, Chang-Keun AU - Oh CK FAU - Jang, Ho-Sun AU - Jang HS FAU - Kim, Mun-Bum AU - Kim MB FAU - Jang, Bong-Seok AU - Jang BS FAU - Kwon, Kyung-Sool AU - Kwon KS LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Dermatol Surg JID - 9504371 SB - IM MH - Abdomen MH - Acrospiroma, Eccrine/*pathology/surgery MH - Adenoma, Sweat Gland/*pathology/surgery MH - Aged MH - Cell Transformation, Neoplastic/*pathology MH - Human MH - Male MH - Neoplasms, Glandular and Epithelial/*pathology/surgery MH - Sweat Gland Neoplasms/*pathology/surgery EDAT- 2003/06/28 05:00 MHDA- 2003/09/05 05:00 AID - 29195 [pii] PST - ppublish SO - Dermatol Surg 2003 Jul;29(7):772-4. PMID- 12677993 OWN - NLM STAT- completed DA - 20030407 DCOM- 20030519 LR - 20031114 IS - 0041-5782 VI - 165 IP - 11 DP - 2003 Mar 10 TI - [Porocarcinoma] PG - 1141-2 AB - Porocarcinoma is a rare tumor in the intraepidermal sweat gland duct. Clinically, it resembles other neoplasms of the skin. A case of a 73-year-old woman with porocarcinoma with its clinical and pathological features is presented. AD - H:S Rigshospitalet, afdeling for plastikkirurgi og brandsar. FAU - Stavis, Rie C AU - Stavis RC FAU - Rasmussen, Susanne E AU - Rasmussen SE FAU - Bonde, Christian T AU - Bonde CT LA - dan PT - Case Reports PT - Journal Article TT - Porokarcinom. PL - Denmark TA - Ugeskr Laeger JID - 0141730 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - English Abstract MH - Female MH - Foot MH - Human MH - Sweat Gland Neoplasms/*pathology EDAT- 2003/04/08 05:00 MHDA- 2003/05/20 05:00 PST - ppublish SO - Ugeskr Laeger 2003 Mar 10;165(11):1141-2. PMID- 12646853 OWN - NLM STAT- completed DA - 20030320 DCOM- 20030410 LR - 20031114 IS - 0194-5998 VI - 128 IP - 3 DP - 2003 Mar TI - Eccrine poroma in the external auditory canal. PG - 439-40 AD - Department of Otolaryngology, Tokai University School of Medicine, Isehara, Japan. t-harada@is.icc.u-tokai.ac.jp FAU - Harada, Tatsuhiko AU - Harada T FAU - Miyamoto, Takayuki AU - Miyamoto T FAU - Takahashi, Masahiro AU - Takahashi M FAU - Tsutsumi, Yutaka AU - Tsutsumi Y LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Otolaryngol Head Neck Surg JID - 8508176 SB - IM MH - Acrospiroma, Eccrine/pathology/*surgery MH - Aged MH - *Ear Canal MH - Ear Neoplasms/pathology/*surgery MH - Human MH - Male MH - Otoscopy MH - Sweat Gland Neoplasms/pathology/*surgery EDAT- 2003/03/21 04:00 MHDA- 2003/04/11 05:00 AID - 10.1067/mhn.2003.37 [doi] AID - S0194599802232520 [pii] PST - ppublish SO - Otolaryngol Head Neck Surg 2003 Mar;128(3):439-40. PMID- 12546762 OWN - NLM STAT- completed DA - 20030127 DCOM- 20030402 LR - 20031114 IS - 1087-2108 VI - 8 IP - 2 DP - 2002 Oct TI - Unusual metastatic spread of a malignant eccrine poroma. PG - 7 AB - Malignant eccrine poroma is a rare skin tumor which commonly presents as verrucous plaques or polypoid growths. We report an 83 year old male who presented with an ulcerating eccrine poroma on the left arm. Though the tumor was excised with wide margins, axillary lymphadenopathy due to regional metastasis developed four months later, followed by lymphangitic cutaneous spread at six months. Though the prognosis for this tumor is better than previously thought, it still must certainly be considered potentially fatal. AD - Department of Plastic and Reconstructive Surgery, Royal Free Hospital, Pond Street, London NW3 2QG. FAU - Erel, Ertan AU - Erel E FAU - Tarr, Gillian AU - Tarr G FAU - Butterworth, Mark S AU - Butterworth MS FAU - Butler, Peter E M AU - Butler PE LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Dermatol Online J JID - 9610776 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - Aged, 80 and over MH - Human MH - Lymphatic Metastasis MH - Male MH - Skin Neoplasms/*secondary MH - Sweat Gland Neoplasms/*pathology EDAT- 2003/01/28 04:00 MHDA- 2003/04/04 05:00 PST - ppublish SO - Dermatol Online J 2002 Oct;8(2):7. PMID- 12482052 OWN - NLM STAT- completed DA - 20021216 DCOM- 20030401 LR - 20031114 IS - 0926-9959 VI - 16 IP - 6 DP - 2002 Nov TI - Malignant eccrine poroma in an unusual location. PG - 631-3 AB - Malignant eccrine poroma is a rare skin appendage tumour, originating from the intraepidermal and upper dermal eccrine ducts. The tumour either arises spontaneously or develops in a long-standing eccrine poroma, generally in elderly people over 60. Clinically, it tends to be a localized lesion, which manifests itself as a nodule or ulcerated tumour, favouring extremities. We report an 83-year-old female with an enlarging and bleeding tumour on her lumbosacral region. This lesion first appeared as a small pigmented papule and progressed to an erythematous patch with central papular portion and some peripheral pigmentation. Histopathology revealed malignant eccrine poroma. Also, immunohistochemically, diffuse and intense p53 staining was observed. Regular pigment pattern, brown globules and black dots were seen in dermoscopic examination. After performing a wide excision, 20 months of follow-up revealed no recurrence or metastasis of the tumour. This case represents an unusually located malignant eccrine poroma with some pigmentation. AD - Department of Dermatology, Medical Faculty, Celal Bayar University, 45020, Manisa, Turkey. mustafaturhan@superonline.com FAU - Sahin, M T AU - Sahin MT FAU - Turel, A AU - Turel A FAU - Gunduz, K AU - Gunduz K FAU - Kandiloglu, A R AU - Kandiloglu AR FAU - Ozturkcan, S AU - Ozturkcan S LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review, Tutorial PL - Netherlands TA - J Eur Acad Dermatol Venereol JID - 9216037 SB - IM MH - Acrospiroma, Eccrine/*diagnosis/pathology MH - Aged MH - Aged, 80 and over MH - Female MH - Human MH - Lumbosacral Region MH - Sweat Gland Neoplasms/*diagnosis/pathology MH - Sweat Glands/pathology RF - 26 EDAT- 2002/12/17 04:00 MHDA- 2003/04/02 05:00 PST - ppublish SO - J Eur Acad Dermatol Venereol 2002 Nov;16(6):631-3. PMID- 12442138 OWN - NLM STAT- completed DA - 20021120 DCOM- 20021224 LR - 20031114 IS - 0151-9638 VI - 129 IP - 10 Pt 1 DP - 2002 Oct TI - [Multiple and painful nodules of the chest] PG - 1179-80 AD - Service de Dermatologie, Hopital Saint Andre, CHU de Bordeaux, France. FAU - Heliot, I AU - Heliot I FAU - Boralevi, F AU - Boralevi F FAU - Lepreux, S AU - Lepreux S FAU - Taieb, A AU - Taieb A LA - fre PT - Case Reports PT - Journal Article TT - Nodules douloureux multiples de la region pectorale. PL - France TA - Ann Dermatol Venereol JID - 7702013 SB - IM MH - Acrospiroma, Eccrine/complications/diagnosis/*pathology MH - Diagnosis, Differential MH - Human MH - Male MH - Middle Aged MH - Pain/etiology MH - Sweat Gland Neoplasms/complications/diagnosis/*pathology MH - Thorax/pathology EDAT- 2002/11/21 04:00 MHDA- 2002/12/27 04:00 AID - MDOI-AD-10-2002-129-10-0151-9638-101019-ART18 [pii] PST - ppublish SO - Ann Dermatol Venereol 2002 Oct;129(10 Pt 1):1179-80. PMID- 12366449 OWN - NLM STAT- completed DA - 20021007 DCOM- 20021126 LR - 20031114 IS - 0007-0963 VI - 147 IP - 4 DP - 2002 Oct TI - Apocrine poroma with follicular differentiation: a case report and immunohistochemical study. PG - 825-7 FAU - Futagami, A AU - Futagami A FAU - Aoki, M AU - Aoki M FAU - Niimi, Y AU - Niimi Y FAU - Ohnishi, T AU - Ohnishi T FAU - Watanabe, S AU - Watanabe S FAU - Kawana, S AU - Kawana S LA - eng PT - Case Reports PT - Letter PL - England TA - Br J Dermatol JID - 0004041 RN - 68238-35-7 (Keratin) SB - IM MH - Acrospiroma, Eccrine/metabolism/*pathology MH - Cell Differentiation MH - Forearm MH - Human MH - Keratin/metabolism MH - Male MH - Middle Aged MH - Sweat Gland Neoplasms/metabolism/*pathology EDAT- 2002/10/09 04:00 MHDA- 2002/11/28 04:00 AID - 4943_12 [pii] PST - ppublish SO - Br J Dermatol 2002 Oct;147(4):825-7. PMID- 12239078 OWN - NLM STAT- completed DA - 20020919 DCOM- 20021017 LR - 20031114 IS - 0361-803X VI - 179 IP - 4 DP - 2002 Oct TI - MR imaging appearance of plantar eccrine acrospiroma (sweat gland tumor). PG - 1079-80 AD - The Ohio State University Medical Center, Columbus, OH 43210, USA. FAU - Reier, Allan R AU - Reier AR FAU - Farooki, Shella AU - Farooki S FAU - Ashman, Carol J AU - Ashman CJ FAU - Miles, Lili AU - Miles L LA - eng PT - Case Reports PT - Journal Article PL - United States TA - AJR Am J Roentgenol JID - 7708173 SB - AIM SB - IM MH - Acrospiroma, Eccrine/complications/*diagnosis/pathology MH - Diabetes Mellitus, Type II/complications MH - Foot Diseases/*diagnosis/pathology MH - Human MH - *Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Sweat Gland Neoplasms/complications/*diagnosis/pathology EDAT- 2002/09/20 10:00 MHDA- 2002/10/18 04:00 PST - ppublish SO - AJR Am J Roentgenol 2002 Oct;179(4):1079-80. PMID- 12207741 OWN - NLM STAT- completed DA - 20020904 DCOM- 20030423 LR - 20031114 IS - 0303-6987 VI - 29 IP - 8 DP - 2002 Sep TI - Aberrant expression of p16 and RB protein in eccrine porocarcinoma. PG - 473-9 AB - BACKGROUND: Eccrine porocarcinoma is a rare malignant tumor of the sweat gland and very little is known about its etiology and molecular basis. METHODS: To investigate the expression of p16 and retinoblastoma (RB) protein and their relationship, an immunohistochemical method was performed on nine eccrine porocarcinomas and five eccrine poromas. Furthermore, one case of eccrine porocarcinoma was analyzed for p16 gene mutation. RESULTS: A striking inverse correlation between p16 and RB expression was noted in all of the eccrine porocarcinomas and poromas. Strong immunoreactivity for p16 protein was observed in both nuclei and cytoplasm of the tumor cells in eight out of nine cases of eccrine porocarcinomas, while RB expression was negative in these cases. Conversely, one case of eccrine porocarcinoma did not show immunoreactivity for p16 protein, whereas RB protein was positive in the scattered nuclei. On the other hand, immunostaining of p16 was negative in all cases of five poromas, whereas RB-positive nuclei were sparse. No p16 gene mutation was detected in the investigated eccrine porocarcinoma case. CONCLUSIONS: These results indicate that detectable p16 protein and loss of RB protein are common occurrences in eccrine porocarcinoma lesions. Moreover, overexpression of p16 protein may be an additional, simple and useful diagnostic marker for eccrine porocarcinoma on routine laboratory screening. AD - Department of Dermatology, Gifu University School of Medicine, Gifu, Japan. FAU - Gu, Li-Hong AU - Gu LH FAU - Ichiki, Yoshiro AU - Ichiki Y FAU - Kitajima, Yasuo AU - Kitajima Y LA - eng PT - Journal Article PL - Denmark TA - J Cutan Pathol JID - 0425124 RN - 0 (Protein p16) RN - 0 (Retinoblastoma Protein) RN - 0 (Tumor Markers, Biological) SB - IM MH - Acrospiroma, Eccrine/genetics/*metabolism/pathology/surgery MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - Genes, p16 MH - Human MH - Immunohistochemistry MH - Lymphatic Metastasis/pathology MH - Male MH - Middle Aged MH - Mutation MH - Neoplasm Recurrence, Local MH - Protein p16/*biosynthesis MH - Retinoblastoma Protein/*biosynthesis MH - Sweat Gland Neoplasms/genetics/*metabolism/pathology/surgery MH - Treatment Outcome MH - *Tumor Markers, Biological EDAT- 2002/09/05 10:00 MHDA- 2003/04/24 05:00 AID - cup290805 [pii] PST - ppublish SO - J Cutan Pathol 2002 Sep;29(8):473-9. PMID- 12145868 OWN - NLM STAT- completed DA - 20020730 DCOM- 20020828 LR - 20031114 IS - 0023-2130 IP - 4 DP - 2002 Apr TI - [Eccrine acrospiroma] PG - 62 FAU - Grinevich, G E AU - Grinevich GE FAU - Oleinikov, K G AU - Oleinikov KG LA - rus PT - Case Reports PT - Journal Article TT - Ekkrinnaia spiradenoma. PL - Ukraine TA - Klin Khir JID - 9516872 SB - IM MH - Acrospiroma, Eccrine/*pathology/surgery MH - Human MH - Male MH - Middle Aged EDAT- 2002/07/31 10:00 MHDA- 2002/08/29 10:01 PST - ppublish SO - Klin Khir 2002 Apr;(4):62. PMID- 12142620 OWN - NLM STAT- completed DA - 20020726 DCOM- 20021223 LR - 20031114 IS - 0193-1091 VI - 24 IP - 4 DP - 2002 Aug TI - Eccrine nevus presenting as a perianal skin tag: a case report and review of the literature. PG - 361-3 AB - We present the case of a 9-year-old girl with a perianal skin tag. This asymptomatic lesion was removed for cosmetic reasons and demonstrated a polypoid lesion with a slightly acanthotic epidermis. The dermis was filled with mature-appearing eccrine ducts and glands but with no other cutaneous appendages, adipocytes, or abnormal vascularity. We believe this to represent a polypoid eccrine nevus and that its presentation is unique. AD - Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, U.S.A. FAU - Mahdavy, Mustafa AU - Mahdavy M FAU - Smoller, Bruce R AU - Smoller BR LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Am J Dermatopathol JID - 7911005 SB - IM MH - Acrospiroma, Eccrine/*pathology/surgery MH - Child MH - Female MH - Hamartoma/*pathology/surgery MH - Human MH - Nevus/*pathology/surgery MH - Sweat Gland Neoplasms/*pathology/surgery EDAT- 2002/07/27 10:00 MHDA- 2002/12/27 04:00 PST - ppublish SO - Am J Dermatopathol 2002 Aug;24(4):361-3. PMID- 12142607 OWN - NLM STAT- completed DA - 20020726 DCOM- 20021223 LR - 20031114 IS - 0193-1091 VI - 24 IP - 4 DP - 2002 Aug TI - Sebaceoma and related neoplasms with sebaceous differentiation: a clinicopathologic study of 30 cases. PG - 294-304 AB - The classification of benign sebaceous neoplasms has been challenged both by the assertion that sebaceous adenomas are really carcinomas and by difficulties in drawing the boundaries between sebaceomas and other lesions. We performed a clinicopathologic study of 30 cases of basaloid neoplasms with sebaceous differentiation, excluding cases of definite sebaceous carcinoma with severe nuclear atypia invading deep within the subcutaneous tissue and those of ocular sebaceous carcinoma. We tried to classify sebaceous neoplasms in six categories with defined histopathologic criteria. All the neoplasms were characterized by aggregations of basaloid cells admixed with sebocytes and sebaceous duct-like structures located in the dermis with or without connection to the epidermis. The categories were 1) sebaceoma (14 cases); 2) trichoblastoma with sebaceous differentiation (3 cases); 3) apocrine poroma with sebaceous differentiation (2 cases); 4) low-grade sebaceous carcinoma (6 cases); 5) sebaceous carcinoma (4 cases); and 6) basal cell carcinoma with sebaceous differentiation (1 case). The sebaceoma was further subclassified as classic type (12 cases) or verruca/seborrheic keratosis type (2 cases). Although most sebaceomas can be distinguished from other lesions, there are problematic cases. We discuss the histopathologic diagnostic problems associated with sebaceoma and also argue in favor of the concept of sebaceous adenoma. AD - Division of Dermatology, Department of Internal Medicine, Saga Medical School, Saga, Japan. misago@post.saga-med.ac.jp FAU - Misago, Noriyuki AU - Misago N FAU - Mihara, Ichiro AU - Mihara I FAU - Ansai, Shin-ichi AU - Ansai S FAU - Narisawa, Yutaka AU - Narisawa Y LA - eng PT - Journal Article PT - Multicenter Study PL - United States TA - Am J Dermatopathol JID - 7911005 SB - IM MH - Acrospiroma, Eccrine/pathology MH - Adenocarcinoma, Sebaceous/*pathology MH - Adult MH - Aged MH - Aged, 80 and over MH - Carcinoma, Basal Cell/*pathology MH - Female MH - Hair Diseases/pathology MH - Human MH - Male MH - Middle Aged MH - Sebaceous Gland Neoplasms/classification/*pathology MH - Sebaceous Glands/*pathology EDAT- 2002/07/27 10:00 MHDA- 2002/12/27 04:00 PST - ppublish SO - Am J Dermatopathol 2002 Aug;24(4):294-304. PMID- 12037445 OWN - NLM STAT- completed DA - 20020530 DCOM- 20020815 LR - 20031114 IS - 1018-8665 VI - 204 IP - 3 DP - 2002 TI - In vivo confocal imaging of pigmented eccrine poroma. PG - 185-9 AB - BACKGROUND: Near-infrared reflectance confocal microscopy (CM) imaging is a noninvasive technique that can be utilized to evaluate histologic features of cutaneous lesions in vivo. OBJECTIVE: A case of pigmented eccrine poroma was examined with CM. Methods: Confocal images were taken to define the features of the lesion and correlated with transverse hematoxylin-eosin (HE)-stained sections. RESULTS: In CM imaging, a well-demarcated homogeneous nest consisting of small uniform cells was seen. The nest contained nonrefractile dark spaces that may represent cuticuli. Many dendritic melanocytes containing melanin were intermingled with the tumor cells, and numerous melanophages were present in the upper dermis. A marked prominence of surrounding vessels was also demonstrated. CONCLUSIONS: CM could well demonstrate the features of a pigmented eccrine poroma, as correlated with transverse HE-stained sections. However, high reflectance signals from melanin had to be carefully considered before a definitive diagnosis could be made. CI - Copyright 2002 S. Karger AG, Basel AD - Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass., USA. FAU - Tachihara, Rieko AU - Tachihara R FAU - Choi, Christine AU - Choi C FAU - Langley, Richard G B AU - Langley RG FAU - Anderson, R Rox AU - Anderson RR FAU - Gonzalez, Salvador AU - Gonzalez S LA - eng PT - Case Reports PT - Journal Article PL - Switzerland TA - Dermatology JID - 9203244 SB - IM MH - Acrospiroma, Eccrine/*pathology/surgery MH - Biopsy, Needle MH - Cheek MH - Follow-Up Studies MH - Human MH - Immunohistochemistry MH - Male MH - Microscopy, Confocal MH - Middle Aged MH - Sensitivity and Specificity MH - Support, Non-U.S. Gov't MH - Sweat Gland Neoplasms/*pathology/surgery MH - Treatment Outcome EDAT- 2002/05/31 10:00 MHDA- 2002/08/16 10:01 AID - drm04185 [pii] PST - ppublish SO - Dermatology 2002;204(3):185-9. PMID- 12025008 OWN - NLM STAT- completed DA - 20020523 DCOM- 20020606 LR - 20031114 IS - 0145-5613 VI - 81 IP - 5 DP - 2002 May TI - Malignant eccrine acrospiroma with metastasis to the parotid. PG - 352-5 AB - Malignant eccrine acrospiromas are rare. Clinically, they resemble other cutaneous lesions. A high index of suspicion must be maintained in cases of histologically benign eccrine acrospiromas for three reasons: (1) malignant transformation can occur, (2) the presence of both benign and malignant tissue can lead to a false-negative diagnosis if only the benign component is obtained in the biopsy specimen, and (3) benign-appearing tumors can recur locally or metastasize. The primary treatment is wide local excision with or without lymph node dissection. The efficacy of adjuvant chemotherapy and radiation therapy requires further investigation. We describe a case of malignant eccrine acrospiroma in an 80-year-old man, and we review the literature on this tumor, with emphasis on the differential diagnosis. AD - Department of Surgery, Baylor University Medical Center, Dallas, USA. FAU - Holden, Bridget AU - Holden B FAU - Colome-Grimmer, Maria AU - Colome-Grimmer M FAU - Savage, Clare AU - Savage C FAU - Stierman, Karen AU - Stierman K FAU - Pou, Anna M AU - Pou AM LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Ear Nose Throat J JID - 7701817 SB - IM MH - Acrospiroma, Eccrine/*pathology/therapy MH - Aged MH - Aged, 80 and over MH - Human MH - Male MH - Parotid Neoplasms/*secondary/therapy MH - Sweat Gland Neoplasms/*pathology/therapy EDAT- 2002/05/25 10:00 MHDA- 2002/06/12 10:01 PST - ppublish SO - Ear Nose Throat J 2002 May;81(5):352-5. PMID- 11952558 OWN - NLM STAT- completed DA - 20020415 DCOM- 20020507 LR - 20031114 IS - 0007-0963 VI - 146 IP - 3 DP - 2002 Mar TI - Eccrine poroma: another cause of a pigmented scalp nodule. PG - 523 AD - Division of Dermatology, Kawaguchi Municipal Medical Center, 180 Nishi-Araijuku, Saitama 333-0833, Japan. FAU - Kakinuma, H AU - Kakinuma H FAU - Kobayashi, M AU - Kobayashi M LA - eng PT - Case Reports PT - Journal Article PL - England TA - Br J Dermatol JID - 0004041 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - Female MH - Human MH - *Pigmentation MH - Scalp/*pathology MH - Sweat Gland Neoplasms/*pathology EDAT- 2002/04/16 10:00 MHDA- 2002/05/08 10:01 AID - 4650 [pii] PST - ppublish SO - Br J Dermatol 2002 Mar;146(3):523. PMID- 11937963 OWN - NLM STAT- completed DA - 20020408 DCOM- 20020513 LR - 20031114 IS - 0151-9638 VI - 129 IP - 2 DP - 2002 Feb TI - [Eccrine porocarcinoma with extensive cutaneous metastasis] PG - 225-8 AB - BACKGROUND: Porocarcinoma is a malignant tumour of the eccrine sweat duct, arising from acrosyringium. The tumoral lesions involve the deep dermal tissue. CASE REPORT: We report the case of an 84 year-old woman, suffering from a porocarcinoma, extensively involving the major part of the left lower limb. The first symptoms appeared two years ago. Hundreds of metastatic papules and small nodules were present, isolated or confluent into large plaques. The clinical picture was very close to lymphangioma. Diagnosis was confirmed by histopathologic examination. Radiotherapy was useful short-term, allowing partial flattening of the lesions and improving lymphatic drainage, thus providing comfort for the patient. It did not prevent a later progression of the tumoral process. DISCUSSION: Porocarcinoma is a rare tumour that usually appears as a single nodule or a plaque, arising from a preexistent eccrine poroma, or developing de novo. Two histopathological variants are described: trabecular or epidermotropic. This latter form, observed in the present case, is more aggressive, leading to frequent local recurrences and/or metastases. Our report is exceptional: the literature shows only one other case with such widespread cutaneous involvement. The clinical course of our case is discussed. AD - Service de Dermatologie, Cliniques Universitaires Saint-Luc-UCL, Bruxelles, Belgique. PierreDominique.Ghislain@advalvas.be FAU - Ghislain, P D AU - Ghislain PD FAU - Marot, L AU - Marot L FAU - Tennstedt, D AU - Tennstedt D FAU - Lachapelle, J M AU - Lachapelle JM LA - fre PT - Case Reports PT - Journal Article TT - Porocarcinome eccrine avec large extension metastatique de voisinage. PL - France TA - Ann Dermatol Venereol JID - 7702013 SB - IM MH - *Acrospiroma, Eccrine/diagnosis/pathology/radiotherapy MH - Aged MH - Aged, 80 and over MH - Biopsy MH - Diagnosis, Differential MH - English Abstract MH - Female MH - Human MH - Neoplasm Metastasis MH - Neoplasm Recurrence, Local MH - Palliative Care MH - Prognosis MH - Radiotherapy Dosage MH - Skin/pathology MH - *Sweat Gland Neoplasms/diagnosis/pathology/radiotherapy EDAT- 2002/04/09 10:00 MHDA- 2002/05/15 10:01 AID - 101976 [pii] PST - ppublish SO - Ann Dermatol Venereol 2002 Feb;129(2):225-8. PMID- 11812953 OWN - NLM STAT- completed DA - 20020128 DCOM- 20020228 LR - 20031114 IS - 0147-5185 VI - 26 IP - 2 DP - 2002 Feb TI - Eccrine porocarcinoma (malignant eccrine poroma). PG - 272-4 FAU - Perna, Cristian AU - Perna C FAU - Cuevas, Jesus AU - Cuevas J FAU - Jimenez-Heffernan, Jose A AU - Jimenez-Heffernan JA FAU - Hardisson, David AU - Hardisson D FAU - Contreras, Felix AU - Contreras F LA - eng PT - Letter PL - United States TA - Am J Surg Pathol JID - 7707904 RN - 0 (CA-15-3 Antigen) RN - 0 (Carcinoembryonic Antigen) SB - IM MH - Acrospiroma, Eccrine/chemistry/*pathology MH - Aged MH - Aged, 80 and over MH - CA-15-3 Antigen/analysis MH - Carcinoembryonic Antigen/analysis MH - Female MH - Human MH - Immunohistochemistry MH - Lymph Nodes/pathology MH - Lymphatic Metastasis MH - Male MH - Middle Aged MH - Neoplasm Recurrence, Local MH - Sweat Gland Neoplasms/chemistry/*pathology EDAT- 2002/01/29 10:00 MHDA- 2002/03/01 10:01 PST - ppublish SO - Am J Surg Pathol 2002 Feb;26(2):272-4. PMID- 11803286 OWN - NLM STAT- completed DA - 20020122 DCOM- 20020307 LR - 20031114 IS - 0193-1091 VI - 24 IP - 1 DP - 2002 Feb TI - Clear-cell porocarcinoma in situ: a cytologic variant of porocarcinoma in situ. PG - 67-71 AB - Poromas are benign neoplasms composed of poroid and cuticular cells. Four histopathologic variants of poromas are accepted, according to the architectural features of the neoplasm: hidroacanthoma simplex or intraepidermal poroma; eccrine poroma, which is a poroma connected to the epidermis that extends to superficial dermis; dermal duct tumor, which develops when the neoplasm is composed of small, solid aggregations of poroid and cuticular cells confined to the dermis with little or no connection with the epidermis; and poroid hidradenoma, which is a solid-cystic, dermal poroma. The malignant counterpart of hidroacanthoma simplex is named malignant hidroacanthoma simplex or porocarcinoma in situ. This report describes an example of clear-cell malignant hidroacanthoma simplex, a cytologic variant of porocarcinoma in situ, which, to our knowledge, has not been previously reported. In contrast with other clear-cell neoplasms, a relation with diabetes mellitus could not be clearly established in this case. AD - Laboratory of Dermatohistopathology, Friedrichshafen, Germany. FAU - Rutten, Arno AU - Rutten A FAU - Requena, Luis AU - Requena L FAU - Requena, Celia AU - Requena C LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Am J Dermatopathol JID - 7911005 RN - 0 (Tumor Markers, Biological) SB - IM MH - Acrospiroma, Eccrine/chemistry/*pathology/surgery MH - Adult MH - Carcinoma in Situ/chemistry/*pathology/surgery MH - Female MH - Human MH - Immunohistochemistry MH - Sweat Gland Neoplasms/chemistry/*pathology/surgery MH - Treatment Outcome MH - Tumor Markers, Biological/analysis EDAT- 2002/01/23 10:00 MHDA- 2002/03/08 10:01 PST - ppublish SO - Am J Dermatopathol 2002 Feb;24(1):67-71. PMID- 11803284 OWN - NLM STAT- completed DA - 20020122 DCOM- 20020307 LR - 20031114 IS - 0193-1091 VI - 24 IP - 1 DP - 2002 Feb TI - Trichoblastoma arising within an apocrine poroma. PG - 59-62 AB - A poroma is a benign neoplasm composed of poroid and cuticular cells and is thought to derive from the eccrine duct. Several recent reports have described cases with sebaceous, follicular, and apocrine differentiation, suggesting a possible apocrine origin, however. Trichoblastoma is a rare benign tumor composed of germinative cells related to the folliculosebaceous-apocrine unit. We report a unique case of a trichoblastoma arising within a poroma with apocrine and sebaceous differentiation. To our knowledge, this exceptional association has not been described previously and may support the theory of the apocrine origin of poromas. AD - Departamento de Anatomia Patologica, Hospital Universitario, Madrid, Spain. FAU - Santos-Briz, Angel AU - Santos-Briz A FAU - Rodriguez-Peralto, Jose Luis AU - Rodriguez-Peralto JL FAU - Miguelez, Ana AU - Miguelez A FAU - Lopez-Rios, Fernando AU - Lopez-Rios F LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Am J Dermatopathol JID - 7911005 SB - IM MH - Acrospiroma, Eccrine/complications/*pathology/surgery MH - Aged MH - Diagnosis, Differential MH - Hair Diseases/complications/*pathology MH - Hair Follicle/*pathology MH - Hamartoma/complications/*pathology/surgery MH - Human MH - Keratosis, Seborrheic/pathology MH - Male MH - Sebaceous Gland Neoplasms/*pathology/surgery EDAT- 2002/01/23 10:00 MHDA- 2002/03/08 10:01 PST - ppublish SO - Am J Dermatopathol 2002 Feb;24(1):59-62. PMID- 11801771 OWN - NLM STAT- completed DA - 20020121 DCOM- 20020215 LR - 20031114 IS - 0193-1091 VI - 23 IP - 5 DP - 2001 Oct TI - P53 protein expression in eccrine poroma and porocarcinoma. PG - 402-6 AB - The role of p53 mutation has been shown in different human malignancies, including various skin cancers. In this study, we examined p53 protein expression in 25 eccrine poromas and 11 porocarcinomas by immunohistochemistry. P53 expression was observed in 88% (22 of 25) of eccrine poromas and 73% (8 of 11) of porocarcinomas. In eccrine poromas, percentage of cells reactive for p53 was less than 5% (low expresser) in 6 cases, 5 to 50% (moderate expresser) in 14 and greater than 50% (high expresser) in 2 cases. In terms of intensity, 13 cases showed weak staining, 8 moderate, and 1 case showed strong reactivity. On the other hand, 2 cases of porocarcinoma were low expresser, 2 were moderate and 4 were high expresser. All of the high expressers had also strong staining. This study has demonstrated that eccrine poromas showed significant p53 expression as much as porocarcinomas and, therefore, p53 positivity cannot be accepted as a valuable parameter for malignancy. P53 gene may involve in the carcinogenetic pathway of porocarcinoma but it is likely that other oncogenes may also have a role. AD - Ege University School of Medicine, Department of Pathology, Bornova, Izmir, Turkey. takalin@med.ege.edu.tr FAU - Akalin, T AU - Akalin T FAU - Sen, S AU - Sen S FAU - Yuceturk, A AU - Yuceturk A FAU - Kandiloglu, G AU - Kandiloglu G LA - eng PT - Journal Article PL - United States TA - Am J Dermatopathol JID - 7911005 RN - 0 (Protein p53) RN - 0 (Tumor Markers, Biological) SB - IM MH - Acrospiroma, Eccrine/*chemistry/pathology MH - Adult MH - Aged MH - Carcinoma/chemistry/pathology MH - Female MH - Human MH - Immunohistochemistry MH - Male MH - Middle Aged MH - Protein p53/*analysis MH - Sweat Gland Neoplasms/*chemistry/pathology MH - Tumor Markers, Biological/analysis EDAT- 2002/01/22 10:00 MHDA- 2002/02/16 10:01 PST - ppublish SO - Am J Dermatopathol 2001 Oct;23(5):402-6. PMID- 11736912 OWN - NLM STAT- completed DA - 20011212 DCOM- 20011227 LR - 20031114 IS - 0007-0963 VI - 145 IP - 5 DP - 2001 Nov TI - Eccrine poromas in a patient with mycosis fungoides treated with electron beam therapy. PG - 830-3 AB - We describe a 72-year-old man with mycosis fungoides (MF) followed up at our hospital for more than 20 years, who has developed 14 eccrine poromas (EPs) in the past 12 years. Twelve of these tumours were ascertained as EP histopathologically without any findings of malignancy and the other two were clinically diagnosed and are not yet resected. To our knowledge, this is the first case report of MF complicated with multiple EPs. In our patient, all EPs arose in skin areas previously irradiated with an electron beam for the treatment of MF, suggesting that electron beam irradiation might have an effect on the development of EPs. AD - Department of Dermatology, Miyazaki Medical College, Kiyotake, Miyazaki, 889-1692, Japan. mkurokawa@post1.miyazaki-med.ac.jp FAU - Kurokawa, M AU - Kurokawa M FAU - Amano, M AU - Amano M FAU - Miyaguni, H AU - Miyaguni H FAU - Tateyama, S AU - Tateyama S FAU - Ogata, K AU - Ogata K FAU - Idemori, M AU - Idemori M FAU - Setoyama, M AU - Setoyama M LA - eng PT - Case Reports PT - Journal Article PL - England TA - Br J Dermatol JID - 0004041 SB - IM MH - Acrospiroma, Eccrine/*etiology MH - Aged MH - Follow-Up Studies MH - Human MH - Male MH - Mycosis Fungoides/*radiotherapy MH - Neoplasms, Radiation-Induced/*etiology MH - Neoplasms, Second Primary/*etiology MH - Skin Neoplasms/radiotherapy MH - Sweat Gland Neoplasms/*etiology EDAT- 2001/12/12 10:00 MHDA- 2002/01/05 10:01 AID - 4475 [pii] PST - ppublish SO - Br J Dermatol 2001 Nov;145(5):830-3. PMID- 11726107 OWN - NLM STAT- completed DA - 20011129 DCOM- 20011213 LR - 20031114 IS - 0001-5547 VI - 45 IP - 6 DP - 2001 Nov-Dec TI - Fine needle aspiration cytology of eccrine acrospiroma. PG - 1083-5 FAU - Punia, R S AU - Punia RS FAU - Handa, U AU - Handa U FAU - Mohan, H AU - Mohan H LA - eng PT - Case Reports PT - Letter PL - United States TA - Acta Cytol JID - 0370307 SB - IM MH - Acrospiroma, Eccrine/*pathology/surgery MH - Adult MH - Biopsy, Needle/methods MH - Child MH - Female MH - Human MH - Sweat Gland Neoplasms/*pathology/surgery EDAT- 2001/12/01 10:00 MHDA- 2002/01/05 10:01 PST - ppublish SO - Acta Cytol 2001 Nov-Dec;45(6):1083-5. PMID- 11576416 OWN - NLM STAT- completed DA - 20010928 DCOM- 20011101 LR - 20031114 IS - 0736-8046 VI - 18 IP - 4 DP - 2001 Jul-Aug TI - Solitary, lobulated, firm nodule. PG - 356-8 AD - Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. FAU - Morrell, D S AU - Morrell DS FAU - Esterly, N B AU - Esterly NB LA - eng PT - Case Reports PT - Clinical Conference PT - Journal Article PL - United States TA - Pediatr Dermatol JID - 8406799 SB - IM MH - Acrospiroma, Eccrine/diagnosis/*pathology/surgery MH - Adolescent MH - Biopsy, Needle MH - Female MH - Follow-Up Studies MH - Human MH - Immunohistochemistry MH - Neoplasm Recurrence, Local/diagnosis/*pathology/surgery MH - Sweat Gland Neoplasms/diagnosis/*pathology/surgery EDAT- 2001/09/29 10:00 MHDA- 2001/11/03 10:01 AID - pde1950 [pii] PST - ppublish SO - Pediatr Dermatol 2001 Jul-Aug;18(4):356-8. PMID- 11568910 OWN - NLM STAT- completed DA - 20010924 DCOM- 20011204 LR - 20031114 IS - 0098-1532 VI - 37 IP - 4 DP - 2001 Oct TI - Eccrine porocarcinoma in a child that evolved rapidly from an eccrine poroma. PG - 412-4 AD - Division of Hematology and Oncology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8. FAU - Valverde, K AU - Valverde K FAU - Senger, C AU - Senger C FAU - Ngan, B Y AU - Ngan BY FAU - Chan, H S AU - Chan HS LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Med Pediatr Oncol JID - 7506654 SB - IM MH - Acrospiroma, Eccrine/*pathology/surgery MH - Biopsy, Needle MH - Cell Transformation, Neoplastic/*pathology MH - Child MH - Diagnosis, Differential MH - Female MH - Follow-Up Studies MH - Human MH - Immunohistochemistry MH - Skin Neoplasms/*pathology/surgery MH - Sweat Gland Neoplasms/*pathology/surgery MH - Treatment Outcome EDAT- 2001/09/25 10:00 MHDA- 2002/01/05 10:01 AID - 10.1002/mpo.1221 [pii] PST - ppublish SO - Med Pediatr Oncol 2001 Oct;37(4):412-4. PMID- 11564266 OWN - NLM STAT- completed DA - 20010920 DCOM- 20011204 LR - 20031114 IS - 0148-396X VI - 49 IP - 4 DP - 2001 Oct TI - Malignant eccrine poroma with spinal and cerebrospinal fluid metastases: case report. PG - 1004-7 AB - OBJECTIVE AND IMPORTANCE: A rare case of metastasizing malignant eccrine poroma (porocarcinoma) is described. This case is unique because metastasis resulted in hydrocephalus in the cerebrospinal fluid and spinal cord compression in the lumbar spine. CLINICAL PRESENTATION: A 57-year-old man presented with acute confusion, lower limb weakness, and urinary concerns. Investigation revealed acute hydrocephalus and extradural cord compression of the lumbar spine. INTERVENTION: The acute hydrocephalous was treated with a ventriculoperitoneal shunt. The spinal cord and conus were decompressed by laminectomy and supplemented with pedicular screw fixation. CONCLUSION: The case reported here is the first with metastases from a malignant eccrine poroma causing spinal cord compression and acute hydrocephalus. Our observation is compared with a review of the literature. AD - Department of Neurosurgery, Hull Royal Infirmary, Anlaby Road, Hull HU3 2JZ, England. samcdum@hotmail.com FAU - Magdum, S A AU - Magdum SA FAU - O'Brien, D P AU - O'Brien DP FAU - O'Reilly, G AU - O'Reilly G FAU - Crooks, D AU - Crooks D LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Neurosurgery JID - 7802914 SB - IM MH - Acrospiroma, Eccrine/diagnosis/pathology/*surgery MH - *Cerebrospinal Fluid MH - Decompression, Surgical MH - Diagnosis, Differential MH - Human MH - Hydrocephalus/diagnosis/pathology/*surgery MH - Lumbar Vertebrae/pathology/*surgery MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Spinal Cord Compression/diagnosis/pathology/surgery MH - Spinal Neoplasms/diagnosis/pathology/*secondary/surgery MH - Sweat Gland Neoplasms/diagnosis/pathology/*surgery EDAT- 2001/09/21 10:00 MHDA- 2002/01/05 10:01 PHST- 2001/Mar/06 [received] PHST- 2001/Jun/04 [accepted] PST - ppublish SO - Neurosurgery 2001 Oct;49(4):1004-7. PMID- 11545426 OWN - NLM STAT- completed DA - 20010906 DCOM- 20020108 LR - 20031114 IS - 1442-6404 VI - 29 IP - 4 DP - 2001 Aug TI - Eccrine poroma of the eyelid. PG - 253-5 AB - A clinicopathological case report of a 71-year-old Caucasoid man with an unusual right lower eyelid lesion, which proved to be an eccrine poroma, is presented. Benign eccrine poromas have not previously been reported to occur on the eyelid. Compete surgical excision of this lesion proved to be curative, with no recurrence after 3 years follow up. Eccrine poromas are common benign tumours of the intraepidermal sweat duct unit. Sweat glands occur commonly on the eyelids and eccrine poroma should be considered in the differential diagnosis of eyelid tumours. AD - The Eyelid, Lacrimal and Orbital Clinic Royal Brisbane Hospital, Herston, Australia. phungvu@ozemail.com.au FAU - Vu, P P AU - Vu PP FAU - Whitehead, K J AU - Whitehead KJ FAU - Sullivan, T J AU - Sullivan TJ LA - eng PT - Case Reports PT - Journal Article PL - Australia TA - Clin Experiment Ophthalmol JID - 100896531 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - Eyelid Neoplasms/*pathology MH - Human MH - Male MH - Sweat Gland Neoplasms/*pathology EDAT- 2001/09/08 10:00 MHDA- 2002/01/10 10:01 PST - ppublish SO - Clin Experiment Ophthalmol 2001 Aug;29(4):253-5. PMID- 11495522 OWN - NLM STAT- completed DA - 20010809 DCOM- 20010906 LR - 20031114 IS - 0926-9959 VI - 15 IP - 2 DP - 2000 Mar TI - Syringoid eccrine carcinoma. PG - 143-6 AB - A rare case of a syringoid eccrine carcinoma in a 52-year-old male patient is described. During the first hospitalization, syringoma was diagnosed, both clinically and histologically, keeping in mind the possibility of its malignant alteration. Difficulties in making a diagnosis with histological and immunohistochemical examinations are reported. The possibility of differential diagnosis of primary breast carcinoma and methods of its exclusion are also described. Treatment of the patient was surgical with good results. AD - Department of Dermatology, University Hospital Sestre milosrdnice Vinogradska cesta 29, Zagreb, Croatia. FAU - Gregurek-Novak, T AU - Gregurek-Novak T FAU - Talan-Hranilovic, J AU - Talan-Hranilovic J FAU - Troskot, N AU - Troskot N FAU - Vucic, M AU - Vucic M FAU - Kruslin, B AU - Kruslin B LA - eng PT - Case Reports PT - Journal Article PL - Netherlands TA - J Eur Acad Dermatol Venereol JID - 9216037 SB - IM MH - Acrospiroma, Eccrine/*pathology/surgery MH - Biopsy, Needle MH - Diagnosis, Differential MH - Follow-Up Studies MH - Human MH - Male MH - Middle Aged MH - Skin Neoplasms/*pathology/surgery MH - Sweat Gland Neoplasms/*pathology/surgery MH - Syringoma/*pathology/surgery EDAT- 2001/08/10 10:00 MHDA- 2001/09/08 10:01 PST - ppublish SO - J Eur Acad Dermatol Venereol 2000 Mar;15(2):143-6. PMID- 11469936 OWN - NLM STAT- completed DA - 20010725 DCOM- 20020129 LR - 20031114 IS - 1075-122X VI - 7 IP - 3 DP - 2001 May-Jun TI - Apocrine poroma of the breast. PG - 195-8 AB - Poromas are sweat gland tumors classically reported to be of eccrine origin. However, it is now recognized that poromas may also be derived from apocrine glands. There are no prior reports of either type of poroma arising on the breast. We report the first case of a poroma of the breast. The lesion was localized to the areola of a 70-year-old woman and mimicked an underlying neoplasm of the breast. Because the histopathology demonstrated apparent continuity of a benign poroma with the infundibula of hair follicles, the diagnosis of apocrine poroma was made. The poroma in this case is of apocrine derivation. This report demonstrates that apocrine poromas should be considered in the clinical differential of acquired lesions on the areola, suggesting an underlying breast tumor. Apocrine poromas that are only partially biopsied may recur. Moreover, since apocrine poromas may potentially develop into apocrine porocarcinomas, analogous to eccrine poromas sometimes transforming into eccrine porocarcinomas, apocrine poromas should be completely excised. AD - Departments of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA. FAU - Azma, A AU - Azma A FAU - Tawfik, O AU - Tawfik O FAU - Casparian, J M AU - Casparian JM LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Breast J JID - 9505539 SB - IM MH - Acrospiroma, Eccrine/*diagnosis/pathology/surgery MH - Aged MH - Apocrine Glands/*pathology MH - Biopsy MH - Diagnosis, Differential MH - Female MH - Human MH - Sweat Gland Neoplasms/*diagnosis/pathology/surgery EDAT- 2001/07/27 10:00 MHDA- 2002/01/30 10:01 AID - tbj20049 [pii] PST - ppublish SO - Breast J 2001 May-Jun;7(3):195-8. PMID- 11422040 OWN - NLM STAT- completed DA - 20010625 DCOM- 20010712 IS - 0007-0963 VI - 144 IP - 6 DP - 2001 Jun TI - Immunohistochemical study of angiotensin receptors in normal human sweat glands and eccrine poroma. PG - 1189-92 AB - BACKGROUND: Angiotensin II exerts its actions through its specific receptors. However, expression of these receptors has not been determined in sweat glands. OBJECTIVES: To clarify the expression and localization of the angiotensin receptors in normal human sweat glands and eccrine poroma. METHODS: Expression of angiotensin type 1 (AT1) and type 2 (AT2) receptors in normal human eccrine and apocrine sweat glands and 12 cases of eccrine poroma was studied using immunohistochemistry. RESULTS: In eccrine sweat glands, the acrosyringium and the inner surfaces and luminal cells of the intradermal duct showed positive staining with AT1. In apocrine sweat glands, the intraepithelial duct and luminal cells of the intradermal duct showed positive staining with AT1. In 12 cases of eccrine poroma, some of the tumour cells in the tumour strands and cells surrounding the luminal structures stained positively. There were no positive findings with AT2. CONCLUSIONS: Studying AT1 distribution may be useful in understanding the pathophysiology of sweat glands and sweat gland tumours. AD - Department of Dermatology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. hitakeda@med.id.yamagata-u.ac.jp FAU - Takeda, H AU - Takeda H FAU - Kondo, S AU - Kondo S LA - eng PT - Journal Article PL - England TA - Br J Dermatol JID - 0004041 RN - 0 (Neoplasm Proteins) RN - 0 (Receptors, Angiotensin) RN - 11128-99-7 (Angiotensin II) SB - IM MH - Acrospiroma, Eccrine/*metabolism MH - Adult MH - Angiotensin II/*metabolism MH - Apocrine Glands/metabolism MH - Eccrine Glands/metabolism MH - Female MH - Human MH - Immunoenzyme Techniques MH - Male MH - Neoplasm Proteins/metabolism MH - Receptors, Angiotensin/*metabolism MH - Sweat Gland Neoplasms/*metabolism MH - Sweat Glands/*metabolism EDAT- 2001/06/26 10:00 MHDA- 2001/07/13 10:01 AID - bjd4229 [pii] PST - ppublish SO - Br J Dermatol 2001 Jun;144(6):1189-92. PMID- 11401679 OWN - NLM STAT- completed DA - 20010612 DCOM- 20010830 LR - 20031114 IS - 0303-6987 VI - 28 IP - 6 DP - 2001 Jul TI - Tumor of the follicular infundibulum with sebaceous differentiation. PG - 314-7 AB - BACKGROUND: Tumor of the follicular infundibulum (TFI) is a relatively rare tumor which clinically presents as a solitary keratotic papule usually on the head and neck which on microscopic examination typically reveals a plate-like fenestrated epithelial tumor composed of pale staining cells. METHODS: We describe a new variant of TFI. An 80-year-old male with a history of multiple basal cell carcinomas and a squamous cell carcinoma presented with a 2-year history of a red, scaly, slightly elevated plaque on the lateral aspect of his right buttock. RESULTS: Histopathological examination revealed plate-like reticulate epithelial outgrowths of large and pale cells with foci of sebaceous differentiation and numerous colloid bodies. Differential diagnosis included superficial basal cell carcinoma with sebaceous and ductal differentiation, tumor of the follicular infundibulum, an unusual fibroepithelioma of Pinkus or an eccrine fibroadenoma with sebaceous differentiation. CONCLUSION: This case illustrates a hybrid adnexal tumor with histologic features common to both tumor of the follicular infundibulum and superficial epithelioma with sebaceous differentiation. AD - Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA. FAU - Mahalingam, M AU - Mahalingam M FAU - Bhawan, J AU - Bhawan J FAU - Finn, R AU - Finn R FAU - Stefanato, C M AU - Stefanato CM LA - eng PT - Case Reports PT - Journal Article PL - Denmark TA - J Cutan Pathol JID - 0425124 SB - IM MH - Acrospiroma, Eccrine/pathology MH - Aged MH - Aged, 80 and over MH - Carcinoma, Basal Cell/*pathology/surgery MH - Carcinoma, Squamous Cell/pathology MH - Diagnosis, Differential MH - Eccrine Glands/pathology MH - Fibroadenoma/pathology MH - Hair Follicle/*pathology MH - Human MH - Male MH - Sebaceous Gland Neoplasms/*pathology/surgery MH - Sebaceous Glands/*pathology EDAT- 2001/06/13 10:00 MHDA- 2001/08/31 10:01 AID - cup280608 [pii] PST - ppublish SO - J Cutan Pathol 2001 Jul;28(6):314-7. PMID- 11395548 OWN - NLM STAT- completed DA - 20010607 DCOM- 20010712 LR - 20031114 IS - 0147-5185 VI - 25 IP - 6 DP - 2001 Jun TI - Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. PG - 710-20 AB - The clinicopathologic characteristics of 69 cases of eccrine porocarcinoma (EP) have been studied. Seven cases of purely in situ disease are included. Forty patients were female, 29 male with ages ranging from 29 to 91 years (mean 73 years). The lower extremity represented the single most common site (44%). Other common sites were the trunk (15 cases, 24%) and head (11 cases, 18%). The histologic diagnosis of EP was predicated on the basis of an irregular tumor at least partly formed of characteristic poromatous basaloid epithelial cells displaying ductal differentiation, and significant cytologic atypia. Forty-seven tumors (68%) contained mature well-formed eccrine ducts having an eosinophilic luminal cuticle, with the remaining tumors containing small ill-formed ducts and/or intracytoplasmic lumina. All ducts were discernible via light microscopy and in 49 cases were highlighted with DPAS stain and/or CEA/EMA immunocytochemistry. A variant with a broad pushing tumor margin and marked nuclear pleomorphism showed some resemblance to proliferative bowenoid dysplasia. In 11 cases (18%) the tumors appeared to arise in continuity with a benign preexistent poroma. A variety of histologic patterns were displayed including clear, squamous, and spindle cell differentiation, mucus cell metaplasia, and colonization by melanocytes. Lymphovascular invasion was present in 9 cases (15%). Three cases showed pagetoid extension of malignant cells (epidermotropism) and appeared to be multifocal. Follow-up was available in 54 patients (78%) with 9 (17%) experiencing local recurrence, 10 developing lymph node metastases (19%), and 6 (11%) experiencing distant metastases or death. Mitoses, the presence of lymphovascular invasion, and tumor depth >7 mm were associated with a poorer prognosis. Dividing tumors into those with a "pushing" or "infiltrating" advancing margin was also predictive of outcome with the latter having an increased risk of local recurrence. This report, the largest series of EP to date, suggests that the incidence of aggressive behavior is less than popularly believed. Furthermore, EP can display a wide variety of histologic patterns that may lead to diagnostic error in the unwary. The large number of cases in this series enables a reliable evaluation of prognostic parameters. A more aggressive clinical course may be indicated by more than 14 mitoses per high power field (hazard ratio [HR] for death 17.0, 95% confidence interval [CI] 2.71-107), lymphovascular invasion by tumor (HR 4.41, CI 1.13-17.2), and depth >7 mm (HR 5.49, CI 1.0-30.3). Thus, mitoses, lymphovascular invasion, and tumor depth should be evaluated in these tumors. We also suggest that tumors presenting an "infiltrative" advancing margin are particularly prone to local recurrence and require wide excision with close attention to the surgical margins by the reporting pathologist. AD - Nuffield Department of Clinical Laboratory Sciences, University of Oxford, UK. FAU - Robson, A AU - Robson A FAU - Greene, J AU - Greene J FAU - Ansari, N AU - Ansari N FAU - Kim, B AU - Kim B FAU - Seed, P T AU - Seed PT FAU - McKee, P H AU - McKee PH FAU - Calonje, E AU - Calonje E LA - eng PT - Journal Article PT - Review PT - Review of Reported Cases PL - United States TA - Am J Surg Pathol JID - 7707904 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - Follow-Up Studies MH - Human MH - Male MH - Middle Aged MH - Sweat Gland Neoplasms/*pathology RF - 40 EDAT- 2001/06/08 10:00 MHDA- 2001/07/13 10:01 PST - ppublish SO - Am J Surg Pathol 2001 Jun;25(6):710-20. PMID- 11332156 OWN - NLM STAT- completed DA - 20010502 DCOM- 20010920 LR - 20031114 IS - 0923-7534 VI - 12 IP - 3 DP - 2001 Mar TI - Metastatic eccrine porocarcinoma: response to docetaxel (Taxotere) chemotherapy. PG - 411-4 AB - BACKGROUND: Eccrine porocarcinoma is an uncommon neoplasm of the intra-epidermal sweat gland duct. PATIENTS AND METHODS: A case of eccrine porocarcinoma in a female renal transplant patient aged 45 years is described with a review of pertinent literature. RESULTS: The primary tumour was highly pleomorphic. In places large and small cells merged and focally the former component infiltrated the epidermis in a manner akin to Paget's disease of the breast. The majority of the tumour was high grade; using the modified Bloom and Richardson grading system, usually applied to mammary ductal carcinomas, the tumour graded as 3. Metastatic disease developed nine months following primary surgical treatment. The metastatic eccrine porocarcinoma was resistant to epirubicin but responded to docetaxel chemotherapy. CONCLUSIONS: There are no data to support the use of adjuvant therapy in the management of eccrine porocarcinoma. The use of the modified Bloom and Richardson grading system may define cases at high risk of relapse in which adjuvant therapy might be considered. Metastatic eccrine porocarcinoma has proven resistant to many chemotherapeutic agents. We report the first use of docetaxel in the management of this disease. The treatment was well tolerated and resulted in marked symptomatic and radiological responses. Treatment with docetaxel should be considered in future cases of this rare tumour. AD - Academic Oncology Unit, Guy's & St. Thomas' Hospitals NHS Trust, Guy's Hospital, London, UK. plunkett@icrf.icnet.uk FAU - Plunkett, T A AU - Plunkett TA FAU - Hanby, A M AU - Hanby AM FAU - Miles, D W AU - Miles DW FAU - Rubens, R D AU - Rubens RD LA - eng PT - Case Reports PT - Journal Article PL - Netherlands TA - Ann Oncol JID - 9007735 RN - 0 (Antineoplastic Agents, Phytogenic) RN - 0 (Taxoids) RN - 114977-28-5 (docetaxel) RN - 33069-62-4 (Paclitaxel) SB - IM MH - Acrospiroma, Eccrine/*drug therapy/pathology/radiography MH - Antineoplastic Agents, Phytogenic/*therapeutic use MH - Female MH - Human MH - Middle Aged MH - Paclitaxel/analogs & derivatives/*therapeutic use MH - Sweat Gland Neoplasms/*drug therapy/pathology/radiography MH - *Taxoids MH - Thorax/pathology MH - Tomography, X-Ray Computed EDAT- 2001/05/03 10:00 MHDA- 2001/09/21 10:01 PST - ppublish SO - Ann Oncol 2001 Mar;12(3):411-4. PMID- 11260623 OWN - NLM STAT- completed DA - 20010322 DCOM- 20010426 LR - 20031114 IS - 0003-9985 VI - 125 IP - 4 DP - 2001 Apr TI - Carcinomas of sweat glands: report of 60 cases. PG - 498-505 AB - CONTEXT: Several aspects of sweat gland carcinomas (incidence, classification, diagnosis, and behavior) have not been definitively clarified and need to be studied further. OBJECTIVE: The clinicopathologic findings of a large series of sweat gland carcinomas, collected during a period of 15 years, are presented. METHODS: Sixty sweat gland carcinomas (41 porocarcinomas, 3 syringomatous carcinomas, 8 ductal carcinomas, 5 adenoid cystic carcinomas, and 3 mucinous carcinomas) were analyzed histologically and immunohistochemically. RESULTS: Porocarcinomas were composed of eosinophilic and clear atypical cells arranged in solid-cystic lobular masses. These tumors were divided into 2 subgroups: horizontal porocarcinomas, showing a prominent intraepidermal component, and nodular porocarcinomas, which demonstrated predominant nodular growth. Syringomatous carcinomas presented keratinizing and nonkeratinizing cysts, dilated tubules (sometimes with a "tadpole" appearance), small neoplastic ducts, solid islands, and cellular cords. Ductal carcinomas were characterized by a prominent formation of tubules, solid islands, and cellular cords. Adenoid cystic carcinomas presented a characteristic pattern, showing basaloid monomorphous cells with moderately atypical nuclei, arranged in cribriform or solid islands and in tubular structures. Mucinous carcinomas were composed of moderately atypical cells with eosinophilic vacuolated cytoplasm, forming solid and cystic islands floating in large mucin pools. Immunohistochemically, cytokeratin was found in neoplastic cells in all cases, carcinoembryonic antigen was detected in 73% of cases, and actin-positive (myoepithelial) cells were not found. CONCLUSIONS: Although numerous studies have been published in recent years, the histologic features, histogenesis, and classification of sweat gland carcinomas still remain controversial and need to be clarified by further studies. AD - Department of Anatomic Pathology, Dermatopathology Section, S.M. Annunziata Hospital, I-50011 Antella, Florence, Italy. cylaur@tin.it FAU - Urso, C AU - Urso C FAU - Bondi, R AU - Bondi R FAU - Paglierani, M AU - Paglierani M FAU - Salvadori, A AU - Salvadori A FAU - Anichini, C AU - Anichini C FAU - Giannini, A AU - Giannini A LA - eng PT - Journal Article PL - United States TA - Arch Pathol Lab Med JID - 7607091 RN - 0 (Actins) RN - 0 (Carcinoembryonic Antigen) RN - 68238-35-7 (Keratin) SB - AIM SB - IM MH - Acrospiroma, Eccrine/chemistry/pathology MH - Actins/analysis MH - Adenocarcinoma/chemistry/classification/*pathology MH - Adenocarcinoma, Mucinous/chemistry/pathology MH - Adenoma, Sweat Gland/chemistry/pathology MH - Adult MH - Aged MH - Aged, 80 and over MH - Carcinoembryonic Antigen/analysis MH - Carcinoma, Adenoid Cystic/chemistry/pathology MH - Child MH - Female MH - Human MH - Immunoenzyme Techniques MH - Keratin/analysis MH - Male MH - Middle Aged MH - Neoplasm Recurrence, Local MH - Sweat Gland Neoplasms/chemistry/classification/*pathology MH - Sweat Glands/pathology EDAT- 2001/03/22 10:00 MHDA- 2001/05/01 10:01 PST - ppublish SO - Arch Pathol Lab Med 2001 Apr;125(4):498-505. PMID- 11168759 OWN - NLM STAT- completed DA - 20010129 DCOM- 20010322 LR - 20031114 IS - 0303-6987 VI - 28 IP - 2 DP - 2001 Feb TI - "Apocrine" poroma: review of the literature and case report. PG - 101-4 AB - BACKGROUND: "Apocrine" poroma has recently been proposed as a new term to designate a distinctive benign skin neoplasm with differentiation toward the folliculosebaceous-apocrine unit. CASE REPORT: In support of alternative differentiation, a case of apocrine poroma is reported in a 73-year-old man. A nodule on the right upper abdomen, which was thought clinically to be seborrheic keratosis or basal cell epithelioma, was excised. HISTOLOGY: Histologically, this neoplasm heterogeniously consisted of poroma-like, sebaceous and follicular epithelial components. Since these components share the common embryologic origin of the folliculosebaceous-apocrine unit, this histologic pattern indicates apocrine differentiation of the tumor. CONCLUSION: This is an additional case to support the term "apocrine" poroma as a diagnosis. AD - Department of Dermatology, Gifu University School of Medicine, Japan. kamihide@cc.gifu-u.ac.jp FAU - Kamiya, H AU - Kamiya H FAU - Oyama, Z AU - Oyama Z FAU - Kitajima, Y AU - Kitajima Y LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review of Reported Cases PL - Denmark TA - J Cutan Pathol JID - 0425124 SB - IM MH - Acrospiroma, Eccrine/*pathology/surgery MH - Aged MH - Apocrine Glands/*pathology MH - Carcinoma, Basal Cell/diagnosis MH - Diagnosis, Differential MH - Granuloma, Pyogenic/diagnosis MH - Human MH - Keratosis, Seborrheic/diagnosis MH - Male MH - Melanoma/diagnosis MH - Sweat Gland Neoplasms/*pathology/surgery MH - Treatment Outcome RF - 12 EDAT- 2001/02/13 11:00 MHDA- 2001/03/27 10:01 AID - cup280207 [pii] PST - ppublish SO - J Cutan Pathol 2001 Feb;28(2):101-4. PMID- 11148476 OWN - NLM STAT- completed DA - 20010209 DCOM- 20010215 LR - 20031114 IS - 0190-9622 VI - 44 IP - 1 DP - 2001 Jan TI - Poromas of the head and neck. PG - 48-52 AB - BACKGROUND: The "eccrine" poroma is a benign neoplasm previously thought to originate from the eccrine sweat gland. Early studies suggested that these were primarily lesions of the hairless acral surfaces. OBJECTIVE: This article reports the clinical and histologic findings of 10 cases of poroma of the head and neck area. METHODS: The clinical and histologic findings of 10 cases of poroma of the head and neck area are compared with 10 poromas occurring on the extremities. RESULTS: Some poromas demonstrated evidence for apocrine origin. Unlike poromas found on the extremities, head and neck poromas were usually asymptomatic and were never correctly diagnosed clinically. Although 9 of 10 poromas on the extremities occurred in male patients, the head and neck poromas showed no gender predilection. CONCLUSION: Clinicians should be aware that poromas can occur in the head and neck area and may be of apocrine origin. AD - Department of Medicine, Division of Dermatology, Pennsylvania State University, Hershey, USA. FAU - Moore, T O AU - Moore TO FAU - Orman, H L AU - Orman HL FAU - Orman, S K AU - Orman SK FAU - Helm, K F AU - Helm KF LA - eng PT - Journal Article PL - UNITED STATES TA - J Am Acad Dermatol JID - 7907132 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Adult MH - Aged MH - Comparative Study MH - Female MH - Head and Neck Neoplasms/*pathology MH - Human MH - Male MH - Middle Aged MH - Retrospective Studies MH - Sweat Gland Neoplasms/*pathology EDAT- 2001/01/10 11:00 MHDA- 2001/03/03 10:01 AID - S0190962201408279 [pii] PST - ppublish SO - J Am Acad Dermatol 2001 Jan;44(1):48-52. PMID- 11053985 OWN - NLM STAT- completed DA - 20001103 DCOM- 20001108 LR - 20031114 IS - 0030-2414 VI - 59 IP - 3 DP - 2000 Sep TI - A unique case of eccrine porocarcinoma with pulmonary lymphangitis and pericardial involvement: biological characterization and clinical aggressiveness. PG - 190-5 AB - A unique case of eccrine porocarcinoma with pulmonary lymphangitis and pericardial involvement is reported. The clinical course was aggressive, leading to the death of the patient a few months after diagnosis. Certain pathologial markers of clinical aggressiveness were retrospectively investigated: p53 and Ki-67 expression were determined by means of immunohistochemistry. Angiogenesis was assessed by determination of intratumor microvessel density at the vascular 'hot spot' with the anti-CD34 monoclonal antibody and quantitative analysis using computerized image analyzer. Both primary tumor and metastatic lymph node presented immunostaining for p53 and Ki-67, with a higher degree of vascularization in the secondary lesions compared to the primary tumor. Our findings suggest a correlation between tumor vascularization and clinicopathological parameters of aggressiveness in malignant eccrine porocarcinoma. Taking into account the disappointing results of current treatments for metastatic eccrine porocarcinoma, the assay of microvessel density may be helpful in selecting the patients of high risk for recurrence or death who may benefit of anti-angiogenic therapies. CI - Copyright 2000 S. Karger AG, Basel. AD - Division of Medical Oncology, Azienda Ospedaliera 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy. FAU - Biondi, E AU - Biondi E FAU - Ranieri, G AU - Ranieri G FAU - Nicolo, A AU - Nicolo A FAU - Gasparini, G AU - Gasparini G LA - eng PT - Case Reports PT - Journal Article PL - SWITZERLAND TA - Oncology JID - 0135054 RN - 0 (Ki-67 Antigen) RN - 0 (Protein p53) RN - 0 (Tumor Markers, Biological) RN - 68238-35-7 (Keratin) SB - IM MH - Acrospiroma, Eccrine/blood supply/*pathology MH - Heart Neoplasms/pathology MH - Human MH - Immunohistochemistry MH - Keratin/analysis MH - Ki-67 Antigen/analysis MH - Lung Neoplasms/pathology/*secondary MH - Lymphangitis/*etiology MH - Lymphatic Metastasis MH - Male MH - Middle Aged MH - Neovascularization, Pathologic/pathology MH - Pericardial Effusion/*etiology/pathology MH - Protein p53/analysis MH - Sweat Gland Neoplasms/blood supply/*pathology MH - Tumor Markers, Biological/analysis EDAT- 2000/10/29 11:00 MHDA- 2001/02/28 10:01 AID - ocl59190 [pii] PST - ppublish SO - Oncology 2000 Sep;59(3):190-5. PMID- 11029882 OWN - NLM STAT- completed DA - 20001128 DCOM- 20001128 LR - 20031114 IS - 0031-2983 VI - 92 IP - 4 DP - 2000 Aug TI - [Cancers of the sweat glands: problems and controversies at the end of the 20th century] PG - 225-35 FAU - Urso, C AU - Urso C FAU - Anichini, C AU - Anichini C LA - ita PT - Editorial PT - Historical Article TT - Carcinomi delle ghiandole sudoripare: problemi e controversie alla fine del secolo XX. PL - ITALY TA - Pathologica JID - 0401123 SB - IM MH - Acrospiroma, Eccrine/pathology MH - Adenoma, Sweat Gland/pathology MH - Carcinoma/pathology MH - Carcinoma, Adenoid Cystic/pathology MH - Carcinoma, Adenosquamous/pathology MH - Carcinoma, Mucoepidermoid/pathology MH - History of Medicine, 19th Cent. MH - History of Medicine, 20th Cent. MH - Human MH - Male MH - Middle Aged MH - Sweat Gland Neoplasms/classification/history/*pathology MH - Syringoma/pathology MH - Terminology EDAT- 2000/10/13 11:00 MHDA- 2001/02/28 10:01 PST - ppublish SO - Pathologica 2000 Aug;92(4):225-35. PMID- 10959320 OWN - NLM STAT- completed DA - 20000925 DCOM- 20000925 LR - 20031114 IS - 0017-7768 VI - 137 IP - 5-6 DP - 1999 Sep TI - [Malignant eccrine poroma--a rare occurrence] PG - 197-200, 263 AB - Malignant eccrine poroma (MEP) is rare and both clinical and histologic diagnosis is often difficult. Therefore, diagnosis is sometimes delayed or even incorrect. We report a case in a 70-year old man with MEP of the leg. He demonstrated typical MEP behavior and the problems of differential diagnosis. AD - Dept. of Plastic and Reconstructive Surgery, Rabin Medical Center (Beilinson Campus), Petah Tikva. FAU - Silfen, R AU - Silfen R FAU - Amir, A AU - Amir A FAU - Feinmesser, M AU - Feinmesser M FAU - Hauben, D J AU - Hauben DJ LA - heb PT - Case Reports PT - Journal Article PL - ISRAEL TA - Harefuah JID - 0034351 SB - IM MH - Acrospiroma, Eccrine/*diagnosis/pathology/surgery MH - Aged MH - Diagnosis, Differential MH - English Abstract MH - Human MH - Male MH - Sweat Gland Neoplasms/*diagnosis/pathology/surgery EDAT- 2000/08/26 11:00 MHDA- 2000/09/30 11:01 PST - ppublish SO - Harefuah 1999 Sep;137(5-6):197-200, 263. PMID- 10944091 OWN - NLM STAT- completed DA - 20001115 DCOM- 20010208 LR - 20031114 IS - 0011-9059 VI - 39 IP - 6 DP - 2000 Jun TI - Eccrine poroma of the heel. PG - 453-4 AD - Department of Podiatric Medicine, Temple University School of Podiatric Medicine, and Hospital of the University of Pennsylvania, Presbyterian Medical Center, Philadelphia 19107, USA. FAU - Lemont, H AU - Lemont H FAU - Snyder, H AU - Snyder H LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Int J Dermatol JID - 0243704 SB - IM MH - Acrospiroma, Eccrine/*diagnosis/pathology MH - Aged MH - Diagnosis, Differential MH - Female MH - Heel MH - Human MH - Sweat Gland Neoplasms/*diagnosis/pathology EDAT- 2000/08/16 11:00 MHDA- 2001/03/03 10:01 PST - ppublish SO - Int J Dermatol 2000 Jun;39(6):453-4. PMID- 10917164 OWN - NLM STAT- completed DA - 20001109 DCOM- 20001207 LR - 20031114 IS - 0303-6987 VI - 27 IP - 7 DP - 2000 Aug TI - Cytokeratin expression of apocrine and eccrine poromas with special reference to its expression in cuticular cells. PG - 367-73 AB - BACKGROUND: There are no immunohistochemical studies on cytokeratin (CK) expression in large series of cases of apocrine poroma. In addition, detailed immunohistochemical analysis of cuticular cells, a specific type of constituent cells of poromas, has not been reported. METHODS: Using the avidin-biotin method, we compared immunostaining patterns of eleven different anti-CK antibodies in 12 cases of apocrine and 21 cases of eccrine poromas, and normal adult skin. RESULTS: Poroid cells were exclusively positive for CK1/5/10/14, CK5/8 and CK14, which were expressed in the outer cells of normal dermal sweat ducts. Poroid cells were heterogeneously stained with anti-CK7, CK8/18, CK 10/11 and CK19 antibodies, which reacted in the inner cells of dermal ducts and in the secretory cells of sweat glands. The cuticular cells showed constant expression of CK1/5/ 10/14 and CK10/11, and various expression patterns of CK5/8, CK6, CK7, CK14, CK8/18, CK17, and CK19. CONCLUSIONS: Based on the keratin immunohistochemistry, the neoplastic cells in eccrine and apocrine poromas are considered to be closely related to the cells of dermal sweat ducts. Also the cuticular cells are considered to occupy an intermediate spectrum between the inner and outer cells of the dermal ducts. Although it is difficult to differentiate apocrine poroma from eccrine poroma by keratin expression patterns alone, the data obtained here can be helpful in differentiation of apocrine poroma from other hair follicle-related neoplasms. AD - Department of Dermatology and Occupational Dermatopathology, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu. yamasam@med.uoeh-u.ac.jp FAU - Yamamoto, O AU - Yamamoto O FAU - Hisaoka, M AU - Hisaoka M FAU - Yasuda, H AU - Yasuda H FAU - Kasai, T AU - Kasai T FAU - Hashimoto, H AU - Hashimoto H LA - eng PT - Journal Article PL - DENMARK TA - J Cutan Pathol JID - 0425124 RN - 68238-35-7 (Keratin) SB - IM EIN - J Cutan Pathol 2001 Jan;28(1):55 MH - Acrospiroma, Eccrine/metabolism/*pathology MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Apocrine Glands/chemistry/*pathology MH - Eccrine Glands/chemistry/*pathology MH - Female MH - Hair Follicle/chemistry/pathology MH - Human MH - Immunohistochemistry MH - Keratin/analysis/*biosynthesis MH - Male MH - Middle Aged MH - Skin/chemistry/pathology MH - Sweat Gland Neoplasms/metabolism/*pathology EDAT- 2000/08/05 11:00 MHDA- 2001/02/28 10:01 PST - ppublish SO - J Cutan Pathol 2000 Aug;27(7):367-73. PMID- 10917110 OWN - NLM STAT- completed DA - 20001227 DCOM- 20001227 LR - 20031114 IS - 0148-7043 VI - 45 IP - 1 DP - 2000 Jul TI - Malignant clear cell hidradenoma with giant metastasis to the axilla. PG - 102 FAU - Yildirim, S AU - Yildirim S FAU - Akoz, T AU - Akoz T FAU - Apaydin, I AU - Apaydin I FAU - Ege, G A AU - Ege GA FAU - Gideroglu, K AU - Gideroglu K LA - eng PT - Case Reports PT - Letter PL - UNITED STATES TA - Ann Plast Surg JID - 7805336 SB - IM MH - Acrospiroma, Eccrine/*pathology/*surgery MH - Axilla MH - Female MH - Human MH - Middle Aged MH - Neoplasm Metastasis MH - Sweat Gland Neoplasms/*pathology EDAT- 2000/08/05 11:00 MHDA- 2001/02/28 10:01 PST - ppublish SO - Ann Plast Surg 2000 Jul;45(1):102. PMID- 10886280 OWN - NLM STAT- completed DA - 20000801 DCOM- 20000801 LR - 20031114 IS - 1076-0512 VI - 26 IP - 7 DP - 2000 Jul TI - Recurrent clear cell hidradenoma of the foot. PG - 685-6 AB - BACKGROUND: Clear cell hidradenoma is an uncommon neoplasm without established optimal treatment. OBJECTIVE: Using Mohs micrographic surgery, a recurrent clear cell hidradenoma of the right foot was treated. METHODS: Case report and literature review. RESULTS: Two stages of Mohs micrographic surgery and subsequent repair successfully treated the recurrent clear cell hidradenoma. No recurrence of the neoplasm has been observed at 11 months follow-up. CONCLUSION: Optimal treatment of clear cell hidradenoma is unestablished. Adequate primary local excision is essential. Mohs micrographic surgery should be considered for treatment, especially on recurrent tumors in critical locations. AD - Department of Dermatology and Otolaryngology, University of Cincinnati, Cincinnati, Ohio, USA. FAU - Will, R AU - Will R FAU - Coldiron, B AU - Coldiron B LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review Literature PL - UNITED STATES TA - Dermatol Surg JID - 9504371 SB - IM MH - Acrospiroma, Eccrine/pathology/*surgery MH - Adult MH - Foot Diseases/pathology/*surgery MH - Human MH - Male MH - Mohs Surgery MH - Neoplasm Recurrence, Local MH - Soft Tissue Neoplasms/pathology/*surgery RF - 7 EDAT- 2000/07/25 11:00 MHDA- 2000/08/06 11:00 AID - dsu99183 [pii] PST - ppublish SO - Dermatol Surg 2000 Jul;26(7):685-6. PMID- 10886761 OWN - NLM STAT- completed DA - 20000901 DCOM- 20000901 LR - 20031114 IS - 0736-8046 VI - 17 IP - 3 DP - 2000 May-Jun TI - Tender blue mass in an 8 year old. PG - 235-7 AD - University of California, San Diego, School of Medicine, Woodland Hills, California, USA. FAU - Yashar, S S AU - Yashar SS FAU - Newbury, R O AU - Newbury RO FAU - Cunningham, B B AU - Cunningham BB LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Pediatr Dermatol JID - 8406799 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Child MH - Human MH - Male MH - Skin Neoplasms/*pathology EDAT- 2000/07/08 11:00 MHDA- 2000/09/09 11:01 AID - pde1764 [pii] PST - ppublish SO - Pediatr Dermatol 2000 May-Jun;17(3):235-7. PMID- 10885405 OWN - NLM STAT- completed DA - 20001018 DCOM- 20001025 LR - 20031114 IS - 0303-6987 VI - 27 IP - 6 DP - 2000 Jul TI - Cell proliferation in skin tumors with ductal differentiation: patterns and diagnostic applications. PG - 292-7 AB - The kinetic features of skin tumors with ductal differentiation (TDD) remain mainly unknown. We selected 88 skin TDD (D-PAS-positive cuticles) classified according to Murphy and Elder's criteria. Tumors studied included 13 poromas, 12 nodular hidradenomas, 10 cylindromas, 6 spiradenomas, 9 syringomas, 9 chondroid syringomas, 7 porocarcinomas, 15 malignant nodular hidradenomas, and 7 not otherwise specified carcinomas. The same tumor areas were evaluated for mitotic figure counting (MFC) and proliferation rate (PR = MIB-1 index), screening 10 consecutive high-power fields (HPFs) in the most cellular areas. Results were recorded by HPF and tumor cellularity, considering both average and standard deviation. Differences were analyzed by Student's t-test and analysis of variance (ANOVA) and considered significant if p<0.05. PR was significantly higher in malignant (23.29 +/- 12.49) than in benign tumors (3.86 +/- 4.44) and in poromanodular hidradenoma (4.99 +/- 3.34) than in spiradenoma-cylindroma-syringoma (1.91 +/- 1.67), but not by malignant tumor type. MFC was significantly higher in malignant (25.52 +/- 4.10) than in benign tumors (1.57 +/- 0.38), showing porocarcinomas the biggest MFC/10 HPF and malignant nodular hidradenomas the highest MFC/1000 cells. PR and MFC are useful malignancy criteria in skin TDD and should be evaluated by tumor cellularity to avoid potential misinterpretations related with tumor heterogeneity. AD - Department of Dermatology, The Royal London Hospital, UK. FAU - Pozo, L AU - Pozo L FAU - Camacho, F AU - Camacho F FAU - Rios-Martin, J J AU - Rios-Martin JJ FAU - Diaz-Cano, S J AU - Diaz-Cano SJ LA - eng PT - Journal Article PL - DENMARK TA - J Cutan Pathol JID - 0425124 RN - 0 (Antibodies, Monoclonal) RN - 0 (Antigens, Nuclear) RN - 0 (Ki-67 Antigen) RN - 0 (Nuclear Proteins) SB - IM MH - Acrospiroma, Eccrine/chemistry/*pathology MH - Adenoma, Sweat Gland/chemistry/*pathology MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Antibodies, Monoclonal MH - Antigens, Nuclear MH - Cell Division MH - Female MH - Human MH - Ki-67 Antigen/analysis MH - Male MH - Middle Aged MH - Mitotic Index MH - Nuclear Proteins/analysis MH - Sweat Gland Neoplasms/chemistry/*pathology MH - Syringoma/chemistry/*pathology EDAT- 2000/07/08 11:00 MHDA- 2001/02/28 10:01 PST - ppublish SO - J Cutan Pathol 2000 Jul;27(6):292-7. PMID- 10871071 OWN - NLM STAT- completed DA - 20001002 DCOM- 20001002 LR - 20031114 IS - 0193-1091 VI - 22 IP - 3 DP - 2000 Jun TI - Apocrine poroma with sebaceous differentiation. PG - 261-3 AB - Poromas have been classified as eccrine neoplasms, but several recent reports of poroid tumors with sebaceous, follicular, and apocrine differentiation have challenged this concept. We report a case of apocrine poroma with sebaceous differentiation. A 69-year-old man presented with an asymptomatic elevated erythematous plaque. Histopathology revealed cellular nests composed of cuboidal poroid cells and sebocytes. The nests varied in size and were entirely intraepidermally arranged in a growth pattern similar to that of hidroacanthoma simplex. Given the common embryologic origin of folliculosebaceous and apocrine units, we believe that this lesion represents an apocrine poroma with sebaceous differentiation. AD - Department of Dermatology, Yonsei University Wonju College of Medicine, Korea. FAU - Lee, N H AU - Lee NH FAU - Lee, S H AU - Lee SH FAU - Ahn, S K AU - Ahn SK LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Am J Dermatopathol JID - 7911005 RN - 0 (Neoplasm Proteins) RN - 0 (Tumor Markers, Biological) SB - IM MH - Acrospiroma, Eccrine/chemistry/*pathology MH - Aged MH - Human MH - Immunoenzyme Techniques MH - Male MH - Neoplasm Proteins/analysis MH - Sebaceous Gland Neoplasms/chemistry/*pathology MH - Tumor Markers, Biological/analysis EDAT- 2000/06/28 11:00 MHDA- 2000/10/07 11:01 PST - ppublish SO - Am J Dermatopathol 2000 Jun;22(3):261-3. PMID- 10735969 OWN - NLM STAT- completed DA - 20000419 DCOM- 20000419 LR - 20031114 IS - 0007-0963 VI - 142 IP - 3 DP - 2000 Mar TI - Apocrine acrosyringeal keratosis in association with syringocystoadenoma papilliferum. PG - 543-7 AB - We report the clinical and histopathological features of a keratosis that developed in association with syringocystadenoma papilliferum. This tumour shows a pinkish, pedunculated, spherical nodule with a cerebriform surface and visible keratinous plugs. In addition to the typical features of syringocystadenoma papilliferum, the tumour shows many hyperkeratotic columns surrounded by acanthotic epidermis with the characteristics of trichilemmal keratinization and keratohyalin granules. This keratosis seems to be derived from the middle to lower portion of the apocrine acrosyringium, based on the distribution of keratohyalin granules and the direct connection with the apocrine acrosyringium in an early lesion. Accordingly, we propose to identify this rare keratosis as apocrine acrosyringeal keratosis. AD - Department of Dermatology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Hirokoji, Kawaramachi, Kamikyo-Ku, Kyoto, Japan. FAU - Kishimoto, S AU - Kishimoto S FAU - Wakabayashi, S AU - Wakabayashi S FAU - Yamamoto, M AU - Yamamoto M FAU - Noda, Y AU - Noda Y FAU - Takenaka, H AU - Takenaka H FAU - Yasuno, H AU - Yasuno H LA - eng PT - Case Reports PT - Journal Article PL - ENGLAND TA - Br J Dermatol JID - 0004041 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Adenoma, Sweat Gland/*pathology MH - Adult MH - Diagnosis, Differential MH - Human MH - Keratosis/*pathology MH - Male MH - Neoplasms, Multiple Primary/*pathology MH - Sweat Gland Neoplasms/*pathology EDAT- 2000/03/29 09:00 MHDA- 2000/04/25 09:00 AID - bjd3375 [pii] PST - ppublish SO - Br J Dermatol 2000 Mar;142(3):543-7. PMID- 10727324 OWN - NLM STAT- completed DA - 20000502 DCOM- 20000502 LR - 20031114 IS - 0190-9622 VI - 42 IP - 4 DP - 2000 Apr TI - Clear cell hidradenoma in a young girl. PG - 693-5 AB - Clear cell hidradenoma was diagnosed in a girl at 3(1/2) years of age. Only one case of hidradenoma has been documented in the first decade of life, although it remains unclear whether it was clear cell hidradenoma. This case demonstrates that clear cell hidradenoma is a rare differential diagnosis of cutaneous tumors even in young children, which is of special interest, because malignant transformations can occur. AD - Department of Dermatology, Ludwig-Maximilians-University, Munich, Germany. faulhaber@iname.com FAU - Faulhaber, D AU - Faulhaber D FAU - Worle, B AU - Worle B FAU - Trautner, B AU - Trautner B FAU - Sander, C A AU - Sander CA LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review of Reported Cases PL - UNITED STATES TA - J Am Acad Dermatol JID - 7907132 SB - IM MH - Acrospiroma, Eccrine/diagnosis/*epidemiology MH - Child, Preschool MH - Diagnosis, Differential MH - Female MH - Human MH - Skin Neoplasms/diagnosis MH - Sweat Gland Neoplasms/diagnosis/*epidemiology RF - 13 EDAT- 2000/03/22 09:00 MHDA- 2000/05/08 09:00 AID - S0190962200408455 [pii] PST - ppublish SO - J Am Acad Dermatol 2000 Apr;42(4):693-5. PMID- 10692827 OWN - NLM STAT- completed DA - 20000307 DCOM- 20000307 LR - 20031114 IS - 0385-2407 VI - 27 IP - 1 DP - 2000 Jan TI - Malignant hidroacanthoma simplex: a case report. PG - 52-5 AB - Hidroacanthoma simplex is a benign tumor of the skin originating from or showing differentiation to the sweat glands. It grossly resembles seborrheic keratosis of Bowen's disease and histologically shows intraepidermal focal growth of epithelial cells. Malignant transformation of this tumor is rare. We report a case of pigmented hidroacanthoma with malignant transformation in a 67-year-old woman. There was a 20-year history of a skin lesion on the right thigh, which first appeared as a small verrucous papule, progressed to a dark-brown colored patch, and then to a pigmented plaque. Histologically, the primary tumor was composed of small squamoid cells with marked cellular atypia. Most of the tumor cells were located in the epidermis. Immunohistochemically, the cytoplasm of some tumor cells showed a positive reaction for epithelial membrane antigen, but not for either carcino-embryonic antigen or the S-100 protein. AD - Department of Dermatology, Chungnam National University School of Medicine, Taejon, Korea. FAU - Lee, W J AU - Lee WJ FAU - Seo, Y J AU - Seo YJ FAU - Yoon, J S AU - Yoon JS FAU - Suhr, K B AU - Suhr KB FAU - Lee, J H AU - Lee JH FAU - Park, J K AU - Park JK FAU - Suh, K S AU - Suh KS LA - eng PT - Case Reports PT - Journal Article PL - JAPAN TA - J Dermatol JID - 7600545 RN - 0 (CA-15-3 Antigen) RN - 0 (S100 Proteins) RN - 68238-35-7 (Keratin) SB - IM MH - Acrospiroma, Eccrine/chemistry/*pathology MH - Aged MH - CA-15-3 Antigen/analysis MH - Female MH - Human MH - Immunohistochemistry MH - Keratin/analysis MH - S100 Proteins/analysis MH - Skin/chemistry/pathology MH - Support, Non-U.S. Gov't MH - Sweat Gland Neoplasms/chemistry/*pathology EDAT- 2000/02/29 09:00 MHDA- 2000/03/11 09:00 PST - ppublish SO - J Dermatol 2000 Jan;27(1):52-5. PMID- 10685460 OWN - NLM STAT- completed DA - 20000321 DCOM- 20000321 LR - 20031114 IS - 0248-8663 VI - 21 IP - 1 DP - 2000 Jan TI - [Lung neoplasms revealing a rare cutaneous tumor: eccrine porocarcinoma] PG - 91-4 AB - INTRODUCTION: Eccrine sweat gland carcinoma, which belongs to the eccrine sweat gland carcinoma family, is a rare malignancy of the skin with a potential aggressive growth and metastatic spread. EXEGESIS: We report here a case of malignant eccrine poroma arising on the upper leg, with widespread pulmonary metastases. CONCLUSION: A brief synopsis of the pathological and clinical aspects of eccrine sweat gland carcinoma is presented with the currently available therapies. AD - Service de medecine interne, hopital Cochin, Paris, France. FAU - Permal, S AU - Permal S FAU - Chemal, N AU - Chemal N FAU - Dhote, R AU - Dhote R FAU - Palangie, A AU - Palangie A FAU - Christoforov, B AU - Christoforov B LA - fre PT - Case Reports PT - Journal Article TT - Metastases pulmonaires revelatrices d'une tumeur cutanee rare: le porocarcinome eccrine. PL - FRANCE TA - Rev Med Interne JID - 8101383 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - Carcinoma, Squamous Cell/*secondary MH - Diagnosis, Differential MH - Eccrine Glands/*pathology MH - English Abstract MH - Female MH - Human MH - Lung Neoplasms/*secondary MH - Prognosis MH - Skin Neoplasms/*pathology MH - Sweat Gland Neoplasms/*pathology EDAT- 2000/02/24 09:00 MHDA- 2000/03/25 09:00 AID - S0248866300872343 [pii] PST - ppublish SO - Rev Med Interne 2000 Jan;21(1):91-4. PMID- 10656009 OWN - NLM STAT- completed DA - 20000217 DCOM- 20000217 LR - 20031114 IS - 0141-0768 VI - 92 IP - 8 DP - 1999 Aug TI - Malignant eccrine poroma of the hand. PG - 410 AD - St George's Hospital, London, UK. FAU - O'Toole, G AU - O'Toole G FAU - Gateley, D AU - Gateley D LA - eng PT - Case Reports PT - Journal Article PL - ENGLAND TA - J R Soc Med JID - 7802879 SB - IM MH - Acrospiroma, Eccrine/*diagnosis/pathology MH - Aged MH - Aged, 80 and over MH - *Hand MH - Human MH - Lymphatic Metastasis MH - Male MH - Sweat Gland Neoplasms/*diagnosis/pathology EDAT- 2000/02/03 09:00 MHDA- 2000/02/19 09:00 PST - ppublish SO - J R Soc Med 1999 Aug;92(8):410. PMID- 10594609 OWN - NLM STAT- completed DA - 20000817 DCOM- 20000817 LR - 20031114 IS - 1076-0512 VI - 25 IP - 11 DP - 1999 Nov TI - Eccrine porocarcinoma treated with Mohs micrographic surgery: A report of five cases. PG - 911-3 AB - BACKGROUND: Eccrine porocarcinoma is a rare, locally aggressive, potentially fatal neoplasm. While wide local excision has traditionally been the treatment of choice, recurrences following excision are common. OBJECTIVE: The purpose of this study was to review the traditional treatments of eccrine porocarcinoma as well as to introduce Mohs micrographic surgery as an alternative to wide local excision. METHODS: We reviewed all cases of eccrine porocarcinoma seen at Emory University between 1985 and 1999. All cases were treated definitively with Mohs micrographic surgery. The clinical characteristics and outcome of each case are summarized. RESULTS: Five patients with eccrine porocarcinoma were treated with Mohs micrographic surgery. There have been no recurrences to date, with an average follow-up of 2.1 years (ranging from 5 months to 4 years). CONCLUSION: Follow-up of five patients supports the view that Mohs micrographic surgery may be an effective treatment for eccrine porocarcinoma. AD - Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA. FAU - Wittenberg, G P AU - Wittenberg GP FAU - Robertson, D B AU - Robertson DB FAU - Solomon, A R AU - Solomon AR FAU - Washington, C V AU - Washington CV LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review of Reported Cases PL - UNITED STATES TA - Dermatol Surg JID - 9504371 SB - IM MH - Acrospiroma, Eccrine/diagnosis/*pathology/*surgery MH - Adult MH - Aged MH - Biopsy, Needle MH - Female MH - Follow-Up Studies MH - Human MH - Male MH - Middle Aged MH - Mohs Surgery/*methods MH - Sweat Gland Neoplasms/diagnosis/*pathology/*surgery MH - Treatment Outcome RF - 19 EDAT- 1999/12/14 09:00 MHDA- 2000/08/19 11:00 AID - dsu99121 [pii] PST - ppublish SO - Dermatol Surg 1999 Nov;25(11):911-3. PMID- 10583081 OWN - NLM STAT- completed DA - 20000302 DCOM- 20000302 LR - 20031114 IS - 0007-0963 VI - 141 IP - 3 DP - 1999 Sep TI - Melanocyte colonization associated with malignant transformation of eccrine poroma. PG - 582-3 FAU - Lee, H J AU - Lee HJ FAU - Jeong, S H AU - Jeong SH FAU - Seo, E J AU - Seo EJ FAU - Ha, S J AU - Ha SJ FAU - Kim, J W AU - Kim JW LA - eng PT - Case Reports PT - Letter PL - ENGLAND TA - Br J Dermatol JID - 0004041 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Cell Movement MH - Human MH - Male MH - Melanocytes/*pathology MH - Middle Aged MH - Sweat Gland Neoplasms/*pathology EDAT- 1999/12/03 09:00 MHDA- 2000/03/04 09:00 AID - bjd3070 [pii] PST - ppublish SO - Br J Dermatol 1999 Sep;141(3):582-3. PMID- 10561775 OWN - NLM STAT- completed DA - 19991130 DCOM- 19991130 LR - 20031114 IS - 0304-4602 VI - 28 IP - 4 DP - 1999 Jul TI - Eccrine porocarcinoma: a case report. PG - 574-7 AB - We report a 58-year-old Chinese female who presented with a pigmented skin lesion on the right thigh, associated with a single ipsilateral inguinal lymph node without distant metastases detected. A wide excision of the tumour, split skin graft coverage and an en-bloc ipsilateral superficial groin dissection was performed. Histopathology revealed malignant skin adnexal tumour or porocarcinoma, with nodal metastases. She is presently at six months follow-up without any recurrence. AD - Department of Plastic Surgery, Singapore General Hospital. FAU - Tan, E AU - Tan E FAU - Ang, E S AU - Ang ES FAU - Foo, C L AU - Foo CL LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review of Reported Cases PL - SINGAPORE TA - Ann Acad Med Singapore JID - 7503289 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Biopsy, Needle MH - Chronic Disease MH - Female MH - Groin MH - Human MH - Lymph Nodes/pathology MH - Lymphatic Metastasis MH - Middle Aged MH - Prognosis MH - Sweat Gland Neoplasms/*pathology MH - Thigh RF - 22 EDAT- 1999/11/24 MHDA- 1999/11/24 00:01 PST - ppublish SO - Ann Acad Med Singapore 1999 Jul;28(4):574-7. PMID- 10491509 OWN - NLM STAT- completed DA - 19991216 DCOM- 19991216 LR - 20031114 IS - 1167-1122 VI - 9 IP - 6 DP - 1999 Sep TI - Eccrine porocarcinoma, tricholemmal carcinoma and multiple squamous cell carcinomas in a single patient. PG - 483-6 AB - A 75-year old woman without remarkable medical history presented with a large eccrine porocarcinoma of the trabelucar type located on her leg. This tumor was associated with two invasive squamous cell carcinomas of the legs, two Bowen's diseases of her thigh and arm and multiple actinic keratoses of the face. Despite major surgery, local recurrence of the porocarcinoma was observed 6 months later. During the 3-year follow-up after a second surgical intervention, this lesion did not reccur, but the patient developed a rapidly enlarging ulcerated tumor of the forehead which proved to be tricholemmal carcinoma. Although no carcinogenetic factor or familial history of multiple neoplasms could be evidenced, the occurrence of multiple tumors of various histogenesis over a 1 year period of time is unlikely to be fortuitous. Such an association of rare adnexal neoplasms has not yet been described. AD - Clinique dermatologique, Hopitaux universitaires, 1, place de l'Hopital, 67091 Strasbourg Cedex, France. FAU - Cribier, B AU - Cribier B FAU - Lipsker, D AU - Lipsker D FAU - Grosshans, E AU - Grosshans E LA - eng PT - Case Reports PT - Journal Article PL - FRANCE TA - Eur J Dermatol JID - 9206420 SB - IM MH - Acrospiroma, Eccrine/diagnosis/*pathology/therapy MH - Aged MH - Carcinoma, Squamous Cell/diagnosis/*pathology/therapy MH - Female MH - Follow-Up Studies MH - Human MH - Neoplasms, Basal Cell/diagnosis/*pathology/therapy MH - Neoplasms, Multiple Primary/diagnosis/*pathology/therapy MH - Skin Neoplasms/diagnosis/*pathology/therapy EDAT- 1999/09/24 MHDA- 1999/09/24 00:01 PST - ppublish SO - Eur J Dermatol 1999 Sep;9(6):483-6. PMID- 10491068 OWN - NLM STAT- completed DA - 20000815 DCOM- 20000815 LR - 20031114 IS - 1076-0512 VI - 25 IP - 9 DP - 1999 Sep TI - Malignant eccrine poroma in an elderly African-American woman. PG - 733-5 AB - BACKGROUND: Eccrine porocarcinoma is a rare, slow-growing malignant tumor arising from the eccrine sweat gland. OBJECTIVE: We present a case of eccrine porocarcinoma of the ear in an elderly African-American woman. Cases of eccrine porocarcinoma have been reported in the literature occurring in facial, extremity, scalp, and genital sites and primarily in Caucasian patients. Rarely are cases described in African-American patients or on the ear. METHODS: We describe the history of the lesion, discuss the current cancer statistics for skin cancer in African Americans, and histology and treatment choices are compared with previously reported cases. RESULTS: We present a case of malignant eccrine poroma of the ear in a 71 year old African-American woman. The tumor was completely excised by Mohs surgery. Transposition flap repair of the Mohs surgical defect was performed. CONCLUSIONS: While African Americans are at low risk of developing skin cancers, it is important to remember that skin cancers can affect patients of any ethnicity and skin tone. Treatment regimens for skin cancers in African-American patients must be chosen appropriately by site of tumor, size of tumor and extent of disease as would be expected for any skin cancer. AD - Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. FAU - McMichael, A J AU - McMichael AJ FAU - Gay, J AU - Gay J LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Dermatol Surg JID - 9504371 SB - IM MH - *Acrospiroma, Eccrine/pathology/surgery MH - Aged MH - *Ear Neoplasms/pathology/surgery MH - *Ear, External MH - Female MH - Human MH - *Sweat Gland Neoplasms/pathology/surgery EDAT- 1999/09/22 09:00 MHDA- 2000/08/19 11:00 AID - dsu99041 [pii] PST - ppublish SO - Dermatol Surg 1999 Sep;25(9):733-5. PMID- 10490189 OWN - NLM STAT- completed DA - 19991021 DCOM- 19991021 LR - 20031114 IS - 0148-7043 VI - 43 IP - 3 DP - 1999 Sep TI - Malignant clear-cell hidradenoma of the toe. PG - 321-3 AB - Malignant sweat gland tumors are rare tumors of the extremity. Their insidious growth patterns and often confusing pathological characteristics can cause confusion with more common benign tumors. However, these tumors cannot be neglected because they do have a propensity to metastasize. Presented is a 56-year-old woman with a malignant clear-cell hidradenoma of the foot actually presenting as a benign lesion. AD - Department of Plastic & Reconstructive Surgery, Medical College of Wisconsin, Milwaukee, USA. FAU - Dzwierzynski, W W AU - Dzwierzynski WW FAU - Fleming, M G AU - Fleming MG LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Ann Plast Surg JID - 7805336 SB - IM MH - Acrospiroma, Eccrine/*pathology/surgery MH - Female MH - Foot Diseases/*pathology/surgery MH - Human MH - Middle Aged MH - Sweat Gland Neoplasms/*pathology/surgery MH - *Toes EDAT- 1999/09/18 MHDA- 1999/09/18 00:01 PST - ppublish SO - Ann Plast Surg 1999 Sep;43(3):321-3. PMID- 10488374 OWN - NLM STAT- completed DA - 19991020 DCOM- 19991020 LR - 20031114 IS - 0028-2162 VI - 143 IP - 31 DP - 1999 Jul 31 TI - [A woman with an advanced malignant clear cell hidradenoma] PG - 1618-21 AB - A 67-year-old patient was admitted for diabetes mellitus. Incidentally a large ulcerating tumour was found on the right upper leg. The patient had been suffering from the lesion for six years but had never dared to show it to her physician. Notwithstanding negative outcome of thin needle aspiration oncological dissection was carried out. Histopathological examination proved the tumour to be a malignant clear cell hidradenoma, which is a rare eccrine tumour. This tumour is known to be aggressive and easily spreads to locoregional lymph nodes. Even though it is a rare disease, the aggressive behaviour and the poor prognosis warrant alertness to this neoplasm. AD - Ziekenhuis Eemland, afd. Heelkunde, Amersfoort. FAU - Buise, M P AU - Buise MP FAU - Kramer, W L AU - Kramer WL FAU - Kniestedt, W J AU - Kniestedt WJ LA - dut PT - Case Reports PT - Journal Article TT - Een vrouw met een voortgeschreden maligne 'clear cell'-hidradenoma. PL - NETHERLANDS TA - Ned Tijdschr Geneeskd JID - 0400770 SB - IM MH - Acrospiroma, Eccrine/complications/*diagnosis/pathology/surgery MH - Aged MH - Diabetes Mellitus, Type I/*complications MH - Diagnosis, Differential MH - English Abstract MH - Fatal Outcome MH - Female MH - Human MH - Leg MH - Lipoma/pathology/surgery MH - Magnetic Resonance Imaging MH - Sweat Gland Neoplasms/complications/*diagnosis/pathology/surgery EDAT- 1999/09/17 MHDA- 1999/09/17 00:01 PST - ppublish SO - Ned Tijdschr Geneeskd 1999 Jul 31;143(31):1618-21. PMID- 10413167 OWN - NLM STAT- completed DA - 19990730 DCOM- 19990730 LR - 20031114 IS - 0022-3085 VI - 90 IP - 1 DP - 1999 Jan TI - Intracranial extension of an eccrine porocarcinoma. Case report and review of the literature. PG - 138-40 AB - Eccrine porocarcinoma is a rare malignant tumor of the true sweat gland. It commonly presents in the lower extremities with lymphatic metastasis. The authors describe the clinical presentation, radiographic evidence, operative discoveries, and pathological findings in a patient with an eccrine porocarcinoma involving the soft tissue of the occiput, which had eroded through the cranium. A review of the literature failed to reveal any other such case. The discussion includes the epidemiology, pathogenesis, treatment, and outcome of eccrine porocarcinomas. The six reported cases of scalp eccrine tumors are reviewed. AD - Division of Neurosurgery, Medical College of Virginia, Richmond 23298, USA. FAU - Ritter, A M AU - Ritter AM FAU - Graham, R S AU - Graham RS FAU - Amaker, B AU - Amaker B FAU - Broaddus, W C AU - Broaddus WC FAU - Young, H F AU - Young HF LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review, Tutorial PL - UNITED STATES TA - J Neurosurg JID - 0253357 SB - AIM SB - IM MH - Acrospiroma, Eccrine/*pathology/radiography/surgery MH - Aged MH - Follow-Up Studies MH - Human MH - Male MH - Neoplasm Invasiveness MH - Radiotherapy Dosage MH - Radiotherapy, Adjuvant MH - Scalp/*pathology/radiography/surgery MH - Skull Neoplasms/*pathology/radiography/surgery MH - Sweat Gland Neoplasms/*pathology/radiography/surgery RF - 13 EDAT- 1999/07/21 MHDA- 1999/07/21 00:01 PST - ppublish SO - J Neurosurg 1999 Jan;90(1):138-40. PMID- 10393458 OWN - NLM STAT- completed DA - 19990721 DCOM- 19990721 LR - 20031114 IS - 1018-8665 VI - 198 IP - 3 DP - 1999 TI - Metastasizing porocarcinoma of the head with lethal outcome. PG - 298-300 AB - Porocarcinoma is a very rare malignant tumor arising from the duct of eccrine sweat glands. Its prognosis is variable. We report on a patient who developed lymph node and multiple distant metastases, and who died of this malignancy only 6 months after the initial diagnosis. AD - Department of Dermatology, University of Freiburg, Germany. FAU - Grimme, H AU - Grimme H FAU - Petres, A AU - Petres A FAU - Bergen, E AU - Bergen E FAU - Wiemers, S AU - Wiemers S FAU - Schopf, E AU - Schopf E FAU - Vanscheidt, W AU - Vanscheidt W LA - eng PT - Case Reports PT - Journal Article PL - SWITZERLAND TA - Dermatology JID - 9203244 SB - IM MH - Abdominal Neoplasms/secondary MH - Acrospiroma, Eccrine/*pathology MH - Fatal Outcome MH - Human MH - *Lymphatic Metastasis MH - Male MH - Middle Aged MH - *Scalp MH - Skin Neoplasms/secondary MH - Sweat Gland Neoplasms/*pathology EDAT- 1999/07/07 MHDA- 1999/07/07 00:01 AID - drm98298 [pii] PST - ppublish SO - Dermatology 1999;198(3):298-300. PMID- 10340869 OWN - NLM STAT- completed DA - 19990702 DCOM- 19990702 LR - 20031114 IS - 0148-7043 VI - 42 IP - 5 DP - 1999 May TI - A rare case of atypical eccrine acrospiroma of the scalp and a literature review. PG - 568-9 AB - Acrospiromas are rare cutaneous lesions of eccrine sweat gland origin that are found most commonly on the extremities. The authors present a rare case of an atypical eccrine acrospiroma arising in the scalp, and a review of the literature. AD - University of Texas Medical Branch, Division of Plastic Surgery, Galveston 77555-0724, USA. FAU - Wilhelmi, B J AU - Wilhelmi BJ FAU - Appelt, E A AU - Appelt EA FAU - Phillips, L G AU - Phillips LG LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review Literature PL - UNITED STATES TA - Ann Plast Surg JID - 7805336 SB - IM MH - Acrospiroma, Eccrine/*surgery MH - Female MH - Human MH - Middle Aged MH - *Scalp MH - Skin Neoplasms/*surgery MH - Sweat Gland Neoplasms/*surgery RF - 13 EDAT- 1999/05/26 MHDA- 1999/05/26 00:01 PST - ppublish SO - Ann Plast Surg 1999 May;42(5):568-9. PMID- 10206055 OWN - NLM STAT- completed DA - 19990512 DCOM- 19990512 LR - 20031114 IS - 0003-987X VI - 135 IP - 4 DP - 1999 Apr TI - A solitary tumor of the left temple. PG - 463, 466 AD - St George's Hospital, London, England. FAU - Cliff, S AU - Cliff S FAU - Otter, M AU - Otter M FAU - Cook, M G AU - Cook MG FAU - Ostlere, L S AU - Ostlere LS LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Arch Dermatol JID - 0372433 SB - AIM SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Adult MH - Facial Neoplasms/*pathology MH - Female MH - Human MH - Sweat Gland Neoplasms/*pathology EDAT- 1999/04/17 MHDA- 1999/04/17 00:01 PST - ppublish SO - Arch Dermatol 1999 Apr;135(4):463, 466. PMID- 10102614 OWN - NLM STAT- completed DA - 19990622 DCOM- 19990622 LR - 20031114 IS - 0893-3952 VI - 12 IP - 3 DP - 1999 Mar TI - Papillary transitional cell carcinoma of the breast: a report of five cases with distinction from eccrine acrospiroma. PG - 287-94 AB - Papillary carcinomas of the female breast exhibit a spectrum of morphologic appearances and might be mistaken for benign intraductal papillary lesions or papillary adnexal neoplasms. We report herein five cases of papillary carcinoma in which the epithelium closely resembled transitional cells of the urinary bladder. Grossly, the tumors had a nodular or papillary appearance, white, tan, or red in color. The microscopic features were those of an intraductal papillary proliferation of solid layers of epithelial cells overlying fibrovascular cores. The proliferating cells assumed a whorled or streaming growth pattern, with flattening of superficial cells. One case showed microinvasion. Comparison with a similar number of cases of the solid variant of papillary carcinoma of the breast showed a greater range of nuclear pleomorphism, mitotic counts, and a more varied immunohistochemical profile in the papillary carcinomas with transitional cell features. Eight cases of eccrine acrospiroma occurring in the female breast also displayed a solid or solid papillary pattern, with flattened superficial cells. These occurred in a younger age group, were located in the dermis or subcutis, and usually had zones of clear cells visible at low magnification. No evidence of recurrent or metastatic disease was found in the four patients for whom follow-up was available; the length of follow-up ranged from 18 months to 11 years. The stimulus for the development of this unusual phenotype is unclear, but the transitional-like variant seems to behave in a fashion similar to that of other types of papillary carcinoma of the breast. Distinction of this malignant lesion from various benign lesions that occur in the same region is mandatory. AD - Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA. FAU - Mooney, E E AU - Mooney EE FAU - Tavassoli, F A AU - Tavassoli FA LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Mod Pathol JID - 8806605 RN - 0 (Tumor Markers, Biological) SB - IM MH - Acrospiroma, Eccrine/metabolism/*pathology MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Breast Neoplasms/metabolism/*pathology MH - Carcinoma, Papillary/metabolism/*pathology MH - Carcinoma, Transitional Cell/metabolism/*pathology MH - Child MH - Diagnosis, Differential MH - Female MH - Human MH - Immunohistochemistry MH - Middle Aged MH - Sweat Gland Neoplasms/metabolism/*pathology MH - Tumor Markers, Biological/metabolism EDAT- 1999/04/02 MHDA- 1999/04/02 00:01 PST - ppublish SO - Mod Pathol 1999 Mar;12(3):287-94. PMID- 10063216 OWN - NLM STAT- completed DA - 19990317 DCOM- 19990317 LR - 20031114 IS - 0385-2407 VI - 26 IP - 1 DP - 1999 Jan TI - Acanthotic type of eccrine poroma on the arm: report of a case. PG - 67-9 AB - A 72-year-old Japanese man with eccrine poroma on the arm is described. To the best of our knowledge, he is the fifth patient with this tumor on the arm reported from Japan. The histopathological type of the tumor of our patient was unique because it was acanthotic; those of the previous patients were all of the intradermal type. AD - Department of Dermatology, Shimane Medical University, Izumo, Japan. FAU - Ohno, T AU - Ohno T FAU - Ueda, D AU - Ueda D FAU - Koike, S AU - Koike S FAU - Dekio, S AU - Dekio S FAU - Jidoi, J AU - Jidoi J LA - eng PT - Case Reports PT - Journal Article PL - JAPAN TA - J Dermatol JID - 7600545 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - Arm MH - Human MH - Male MH - Sweat Gland Neoplasms/*pathology EDAT- 1999/03/04 MHDA- 1999/03/04 00:01 PST - ppublish SO - J Dermatol 1999 Jan;26(1):67-9. PMID- 9990263 OWN - NLM STAT- completed DA - 19990225 DCOM- 19990225 LR - 20031114 IS - 0001-5547 VI - 41 IP - 4 Suppl DP - 1997 Jul-Aug TI - Porocarcinoma detected by fine needle aspiration biopsy of a node metastasis. A case report. PG - 1305-9 AB - BACKGROUND: Porocarcinomas were first reported by Pinkus and Meherengan in 1963 as uncommon malignant adnexal tumors of the skin characterized by epidermotropism with pagetoid diffusion within the epidermis. CASE: The cytologic findings of an eccrine porocarcinoma lymph node metastasis in a 65-year-old female and histologic features of the skin recurrence are reported. Metastasis was firstly identified by fine needle aspiration biopsy (FNAB) performed on one inguinal lymph node. Cytologically the tumor was characterized by atypical malignant cells showing clear granular or keratinized cytoplasm and vesicular nuclei, with prominent nucleoli, which were irregularly dispersed or forming nests or cords, sometimes harboring central necrosis. The skin metastasis, detected after the cytologic FNAB diagnosis, showed superficial dissemination within the epidermis and dermal invasion. CONCLUSION: Cytologic diagnosis of porocarcinoma metastases by FNAB is important for adequate treatment, but adherence to strict diagnostic criteria is necessary. The tumor cells could be histogenetically related to the intraepidermal duct cells of the eccrine sweat glands, and pagetoid diffusion is considered a sort of homing phenomenon. AD - Institute of Anatomic Pathology, University of Padua, Italy. FAU - Blandamura, S AU - Blandamura S FAU - Altavilla, G AU - Altavilla G FAU - Antonini, C AU - Antonini C FAU - Marchetti, M AU - Marchetti M FAU - Piazza, M AU - Piazza M LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Acta Cytol JID - 0370307 SB - IM MH - Acrospiroma, Eccrine/diagnosis/*pathology MH - Aged MH - Biopsy, Needle MH - Female MH - Human MH - *Lymphatic Metastasis MH - Recurrence MH - Sweat Gland Neoplasms/diagnosis/*pathology EDAT- 1999/02/17 MHDA- 1999/02/17 00:01 PST - ppublish SO - Acta Cytol 1997 Jul-Aug;41(4 Suppl):1305-9. PMID- 9926472 OWN - NLM STAT- completed DA - 19990224 DCOM- 19990224 LR - 20001218 IS - 0294-1260 VI - 43 IP - 4 DP - 1998 Aug TI - [Non-melanomatous malignant skin tumors of the hand] PG - 401-9 AB - Non-melanomatous malignant skin tumors of the hand are the same as those observed on other parts of the body, but with specific characteristics of frequency, aetiology, site and sometimes misleading clinical features. The author analyses these characteristics in relation to precancerous tumors: solar keratoses, arsenical keratoses, radiation dermatitis, kerato-acanthomas, Bowen's disease and malignant tumors: basal cell, squamous cell and other rarer carcinomas. He then outlines the principles of surgical treatment with reference to anaesthesia, usually local or regional, and resection, whose extent and depth depend on the nature and site of the lesion. FAU - Glicenstein, J AU - Glicenstein J LA - fre PT - Journal Article TT - Les tumeurs malignes cutanees non melaniques de la main. PL - FRANCE TA - Ann Chir Plast Esthet JID - 8305839 SB - IM MH - Acrospiroma, Eccrine/pathology/surgery MH - Carcinoma, Basal Cell/pathology/surgery MH - Carcinoma, Merkel Cell/pathology/surgery MH - Carcinoma, Squamous Cell/pathology/surgery MH - Dermatofibroma/pathology/surgery MH - Diagnosis, Differential MH - English Abstract MH - Fingers MH - *Hand MH - Hand Dermatoses/diagnosis/pathology MH - Human MH - Precancerous Conditions/diagnosis/pathology/*surgery MH - Sarcoma, Kaposi/pathology/surgery MH - Skin/pathology MH - Skin Neoplasms/diagnosis/pathology/*surgery MH - Sweat Gland Neoplasms/pathology/surgery EDAT- 1999/02/02 MHDA- 1999/02/02 00:01 PST - ppublish SO - Ann Chir Plast Esthet 1998 Aug;43(4):401-9. PMID- 9790112 OWN - NLM STAT- completed DA - 19981216 DCOM- 19981216 LR - 20031114 IS - 0193-1091 VI - 20 IP - 5 DP - 1998 Oct TI - Poral neoplasm with combined sebaceous and apocrine differentiation. PG - 491-4 AD - Istituto di Scienze Dermatologiche Universita degli Studi Di Milano, IRCCS Ospedale Maggiore di Milano, Milan, Italy. FAU - Gianotti, R AU - Gianotti R FAU - Coggi, A AU - Coggi A FAU - Alessi, E AU - Alessi E LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Am J Dermatopathol JID - 7911005 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - Apocrine Glands/*pathology MH - Cell Differentiation MH - Human MH - Male MH - Sebaceous Glands/*pathology MH - Skin Neoplasms/*pathology EDAT- 1998/10/28 MHDA- 1998/10/28 00:01 PST - ppublish SO - Am J Dermatopathol 1998 Oct;20(5):491-4. PMID- 9747272 OWN - NLM STAT- completed DA - 19981027 DCOM- 19981027 LR - 20031114 IS - 0151-9638 VI - 125 IP - 4 DP - 1998 Apr TI - [Pigmented eccrine poroma] PG - 281 AD - Clinique de Dermatologie, Hopital Universitaire de Geneve. FAU - Pechere, M AU - Pechere M FAU - Roten, S AU - Roten S FAU - Piletta, P AU - Piletta P FAU - Harms, M AU - Harms M FAU - Krischer, J AU - Krischer J LA - fre PT - Case Reports PT - Journal Article TT - Porome eccrine pigmente. PL - FRANCE TA - Ann Dermatol Venereol JID - 7702013 SB - IM SB - N MH - Acrospiroma, Eccrine/*diagnosis/pathology MH - Adolescent MH - Diagnosis, Differential MH - Human MH - Male MH - *Skin Pigmentation MH - Sweat Gland Neoplasms/*diagnosis/pathology EDAT- 1998/09/25 MHDA- 1998/09/25 00:01 AID - 59028 [pii] PST - ppublish SO - Ann Dermatol Venereol 1998 Apr;125(4):281. PMID- 9723060 OWN - NLM STAT- completed DA - 19980915 DCOM- 19980915 LR - 20031114 IS - 1076-0512 VI - 24 IP - 8 DP - 1998 Aug TI - Recurrent malignant acrospiroma. Treatment by chest wall excision. PG - 908-12; discussion 911-2 AB - Malignant acrospiroma is an uncommon tumor of the eccrine sweat gland. In contrast to its relatively more common benign counterpart, malignant acrospiroma is highly invasive, often with significant lymphatic and distant metastasis. The establishment of this diagnosis is difficult on both clinical and histopathologic grounds. After diagnosis, wide surgical excision is warranted to completely extirpate these lesions. We report the case of a 66-year-old female with a recurrent malignant acrospiroma. This patient's tumor was removed by wide radical resection, including chest wall excision, followed by reconstructive surgery and radiotherapy. After 16 months there is no evidence of local recurrence or distant metastasis. AD - Section of Surgical Oncology, Louisiana State University Medical Center, New Orleans, USA. FAU - Long, W P AU - Long WP FAU - Dupin, C AU - Dupin C FAU - Levine, E A AU - Levine EA LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Dermatol Surg JID - 9504371 SB - IM EIN - Dermatol Surg 1998 Nov;24(11):1255 MH - Acrospiroma, Eccrine/pathology/radiotherapy/*surgery MH - Aged MH - Diagnosis, Differential MH - Female MH - Human MH - Leiomyosarcoma/diagnosis MH - Neoplasm Invasiveness MH - Neoplasm Recurrence, Local/pathology/radiotherapy/*surgery MH - Radiotherapy, Adjuvant MH - Reconstructive Surgical Procedures MH - Skin Neoplasms/diagnosis MH - Sweat Gland Neoplasms/pathology/radiotherapy/*surgery MH - Thoracic Neoplasms/pathology/radiotherapy/*surgery MH - Thoracic Surgical Procedures EDAT- 1998/09/02 MHDA- 1998/09/02 00:01 AID - S1076051298001058 [pii] PST - ppublish SO - Dermatol Surg 1998 Aug;24(8):908-12; discussion 911-2. PMID- 9620493 OWN - NLM STAT- completed DA - 19980811 DCOM- 19980811 LR - 20031114 IS - 0011-9059 VI - 37 IP - 5 DP - 1998 May TI - Eccrine poroma associated with Bowen's disease. PG - 399-400 FAU - Watanabe, T AU - Watanabe T FAU - Murakami, T AU - Murakami T FAU - Okochi, H AU - Okochi H FAU - Kikuchi, K AU - Kikuchi K FAU - Furue, M AU - Furue M LA - eng PT - Case Reports PT - Letter PL - UNITED STATES TA - Int J Dermatol JID - 0243704 SB - IM MH - Acrospiroma, Eccrine/*etiology/pathology MH - Aged MH - Aged, 80 and over MH - Bowen's Disease/*complications/pathology MH - Diagnosis, Differential MH - Female MH - Human MH - Skin Neoplasms/*complications/pathology MH - Sweat Gland Neoplasms/*etiology/pathology EDAT- 1998/06/10 MHDA- 1998/06/10 00:01 PST - ppublish SO - Int J Dermatol 1998 May;37(5):399-400. PMID- 9609280 OWN - NLM STAT- completed DA - 19980618 DCOM- 19980618 LR - 20031114 IS - 0306-5456 VI - 105 IP - 4 DP - 1998 Apr TI - Malignant eccrine poroma of the vulva. PG - 471-2 AD - University Department of Pathology, Western Infirmary, Glasgow, UK. FAU - Stephen, M R AU - Stephen MR FAU - Matalka, I AU - Matalka I FAU - Hanretty, K AU - Hanretty K LA - eng PT - Case Reports PT - Journal Article PL - ENGLAND TA - Br J Obstet Gynaecol JID - 7503752 SB - AIM SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - Aged, 80 and over MH - Female MH - Frail Elderly MH - Human MH - Sweat Gland Neoplasms/*pathology MH - Vulvar Neoplasms/*pathology EDAT- 1998/06/03 MHDA- 1998/06/03 00:01 PST - ppublish SO - Br J Obstet Gynaecol 1998 Apr;105(4):471-2. PMID- 9580812 OWN - NLM STAT- completed DA - 19980521 DCOM- 19980521 LR - 20031114 IS - 0007-0963 VI - 138 IP - 3 DP - 1998 Mar TI - Eccrine porocarcinoma with melanocyte colonization. PG - 519-21 AB - We describe a 74-year-old Japanese man with a pigmented eccrine porocarcinoma (malignant eccrine poroma). The patient had a brown-black nodule measuring 9 x 7 mm on his leg. Microscopically, the tumour, which had invaded the reticular dermis, was composed of poroid cells with large and small intracytoplasmic lumina. The tumour cells showed cytological pleomorphism and frequent, often abnormal, mitotic figures. Many dendritic melanocytes containing melanin were intermingled with the tumour cells. The poroid cells were diffusely positive for cytokeratin, while the dendritic cells containing melanin were positive for S-100 protein and HMB-45. Ten months of follow-up revealed no recurrence or metastasis of the tumour. AD - Pathology Division, National Cancer Center Research Institute, Tokyo, Japan. FAU - Nakanishi, Y AU - Nakanishi Y FAU - Matsuno, Y AU - Matsuno Y FAU - Shimoda, T AU - Shimoda T FAU - Wada, T AU - Wada T FAU - Yamazaki, N AU - Yamazaki N FAU - Yamamoto, A AU - Yamamoto A FAU - Hirohashi, S AU - Hirohashi S LA - eng PT - Case Reports PT - Journal Article PL - ENGLAND TA - Br J Dermatol JID - 0004041 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - Diagnosis, Differential MH - Follow-Up Studies MH - Human MH - Male MH - Melanocytes/*pathology MH - Melanoma/diagnosis MH - Sweat Gland Neoplasms/*pathology EDAT- 1998/05/15 MHDA- 1998/05/15 00:01 PST - ppublish SO - Br J Dermatol 1998 Mar;138(3):519-21. PMID- 9546060 OWN - NLM STAT- completed DA - 19980424 DCOM- 19980424 LR - 20031114 IS - 0165-4608 VI - 102 IP - 2 DP - 1998 Apr 15 TI - Characterization of a malignant eccrine poroma by cytogenetic and fluorescence in situ hybridization techniques. PG - 100-3 AB - We have cytogenetically and by fluorescence in situ hybridization (FISH) analyzed short-term cultures from a malignant eccrine poroma, a type of tumor in which chromosomal abnormalities have previously not been reported. Combining the results from G-banding and FISH, the karyotype was interpreted as 50,XX,t(3;11;12)(q21;p15;q15),+5,+7,+9, +9,t(12;22)(q13;q13),+del(12)(q15),der(15)t(3;15) (q23;p13),der(17)t(8;17)(q22;p13),-20,add(22)(q13). AD - Department of Clinical Genetics, University Hospital, Lund, Sweden. FAU - Jin, Y AU - Jin Y FAU - Jin, C AU - Jin C FAU - Mertens, F AU - Mertens F FAU - Persson, B AU - Persson B FAU - Jonsson, N AU - Jonsson N LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Cancer Genet Cytogenet JID - 7909240 SB - IM MH - Acrospiroma, Eccrine/*genetics/pathology MH - Aged MH - *Chromosome Aberrations MH - Chromosome Banding MH - Female MH - Human MH - In Situ Hybridization, Fluorescence MH - Karyotyping MH - Support, Non-U.S. Gov't MH - Sweat Gland Neoplasms/*genetics/pathology EDAT- 1998/04/18 MHDA- 1998/04/18 00:01 AID - S0165460897003476 [pii] PST - ppublish SO - Cancer Genet Cytogenet 1998 Apr 15;102(2):100-3. PMID- 9375470 OWN - NLM STAT- completed DA - 19971209 DCOM- 19971209 LR - 20031114 IS - 0385-2407 VI - 24 IP - 10 DP - 1997 Oct TI - A case of hidroacanthoma simplex. PG - 678-81 AB - There are many conditions characterized by nests of cells within the epidermis. One of them, hidroacanthoma simplex, has been regarded as an epidermal tumor differentiating to intraepidermal eccrine duct cell. We report a case of hidroacanthoma simplex with the results of immunohistochemical study. Staining for 35 beta H11 (reacting with keratin No. 8), 35 beta E12 (reacting with keratin No. 1, 5, 10, 11), S-100 protein, and CEA was negative in the tumor cell nests; these monoclonal antibodies stained the nests of eccrine poroma. AD - Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea. FAU - Suh, H S AU - Suh HS FAU - Lee, H J AU - Lee HJ FAU - Kim, H S AU - Kim HS FAU - Choi, J H AU - Choi JH FAU - Sung, K J AU - Sung KJ FAU - Moon, K C AU - Moon KC FAU - Koh, J K AU - Koh JK LA - eng PT - Case Reports PT - Journal Article PL - JAPAN TA - J Dermatol JID - 7600545 RN - 0 (S100 Proteins) RN - 0 (Tumor Markers, Biological) RN - 68238-35-7 (Keratin) SB - IM MH - *Acrospiroma, Eccrine/chemistry/pathology MH - Aged MH - Aged, 80 and over MH - Female MH - Human MH - Keratin/analysis MH - S100 Proteins/analysis MH - *Sweat Gland Neoplasms/chemistry/pathology MH - Tumor Markers, Biological/analysis EDAT- 1997/12/31 MHDA- 1997/12/31 00:01 PST - ppublish SO - J Dermatol 1997 Oct;24(10):678-81. PMID- 9331202 OWN - NLM STAT- completed DA - 19971016 DCOM- 19971016 LR - 20031114 IS - 0161-6420 VI - 104 IP - 10 DP - 1997 Oct TI - Porocarcinoma of the eyelid. PG - 1626-8 AB - PURPOSE: The purpose of this report is to describe the clinical and histopathologic findings in a patient with porocarcinoma of the eyelid. METHODS: The case of a 68-year-old woman with a nodular lesion of the eyelid was studied, and the pertinent literature reviewed. RESULTS: No previous description of porocarcinoma of the eyelid was found in the literature. The present case presented with a nodular lesion of the right lower eyelid of 1-year duration. The tumor was completely excised. Microscopic study revealed ductal structures within lobules of tumor cells. CONCLUSIONS: Porocarcinoma is a rare cutaneous adnexal tumor arising from the eccrine secretory apparatus. Because the clinical behavior of this cancer includes deep invasion, regional lymphatic spread, and distant metastases, complete surgical excision is recommended, and should be verified by either conventional frozen sections or Mohs' micrographic sections. AD - Department of Ophthalmology, Strong Memorial Hospital, Rochester, New York, USA. FAU - Boynton, J R AU - Boynton JR FAU - Markowitch, W Jr AU - Markowitch W Jr LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Ophthalmology JID - 7802443 SB - IM MH - Acrospiroma, Eccrine/*pathology/surgery MH - Aged MH - Eyelid Neoplasms/*pathology/surgery MH - Female MH - Human MH - Sweat Gland Neoplasms/*pathology/surgery EDAT- 1997/10/23 22:22 MHDA- 2001/03/28 10:01 PST - ppublish SO - Ophthalmology 1997 Oct;104(10):1626-8. PMID- 9335250 OWN - NLM STAT- completed DA - 19971113 DCOM- 19971113 LR - 20031114 IS - 0193-1091 VI - 19 IP - 5 DP - 1997 Oct TI - Clear-cell porocarcinoma: another cutaneous marker of diabetes mellitus. PG - 540-4 AB - The relationship between clear-cell syringoma and diabetes mellitus is well established. We present a case of clear-cell porocarcinoma in a diabetic patient. The lesion consisted of a 5-cm nodule on the lateral aspect of the left leg. Histopathologically, the neoplasm was composed of irregular aggregations of neoplastic cells with striking clear-cell appearance, showing features of ductal differentiation. The clear-cell appearance of neoplastic cells was due to glycogen accumulation within their cytoplasm. Immunohistochemistry and ultrastructural studies also supported the diagnosis of a neoplasm with sweat ductal differentiation. Enzyme histochemical reactions for phosphorylase immunoreactivity on fresh, unfixed sections of the neoplasm demonstrated that this immunoreactivity was remarkably decreased. Some adnexal neoplasms of the skin mostly composed of clear cells may be cutaneous markers of diabetes mellitus. Phosphorylase activity deficiency in diabetic patients may be responsible for glycogen accumulation in neoplastic cells resulting in clear-cell appearance of these neoplasms. AD - Department of Dermatology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain. FAU - Requena, L AU - Requena L FAU - Sarasa, J L AU - Sarasa JL FAU - Pique, E AU - Pique E FAU - Farina, M C AU - Farina MC FAU - Olivares, M AU - Olivares M FAU - Martin, L AU - Martin L LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Am J Dermatopathol JID - 7911005 RN - 0 (CA-15-3 Antigen) RN - 0 (Tumor Markers, Biological) RN - 9005-79-2 (Glycogen) RN - EC 2.4.1.- (Phosphorylases) SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - CA-15-3 Antigen/analysis MH - Cell Differentiation MH - Cell Nucleus/ultrastructure MH - Cytoplasm/ultrastructure MH - Cytoplasmic Granules/ultrastructure MH - Diabetes Mellitus, Type II/enzymology/*pathology MH - Eccrine Glands/pathology MH - Glycogen/analysis MH - Human MH - Immunohistochemistry MH - Male MH - Microvilli/ultrastructure MH - Phosphorylases/analysis/deficiency MH - Skin Neoplasms/*pathology MH - Tumor Markers, Biological/analysis EDAT- 1997/10/23 MHDA- 1997/10/23 00:01 PST - ppublish SO - Am J Dermatopathol 1997 Oct;19(5):540-4. PMID- 9301154 OWN - NLM STAT- completed DA - 19971014 DCOM- 19971014 LR - 20031114 IS - 0385-2407 VI - 24 IP - 8 DP - 1997 Aug TI - A case of rapidly-growing eccrine poroma during pregnancy. PG - 554-5 FAU - Ban, M AU - Ban M FAU - Kitajima, Y AU - Kitajima Y LA - eng PT - Case Reports PT - Letter PL - JAPAN TA - J Dermatol JID - 7600545 SB - IM MH - Acrospiroma, Eccrine/diagnosis/*pathology/surgery MH - Adult MH - Diagnosis, Differential MH - Disease-Free Survival MH - Female MH - Human MH - Pregnancy MH - Pregnancy Complications, Neoplastic/diagnosis/*pathology/surgery MH - *Pregnancy Outcome MH - Sweat Gland Neoplasms/diagnosis/*pathology/surgery EDAT- 1997/09/25 MHDA- 1997/09/25 00:01 PST - ppublish SO - J Dermatol 1997 Aug;24(8):554-5. PMID- 9301149 OWN - NLM STAT- completed DA - 19971014 DCOM- 19971014 LR - 20031114 IS - 0385-2407 VI - 24 IP - 8 DP - 1997 Aug TI - A case of eccrine poroma with multiple transepidermal elimination. PG - 539-42 AB - The skin functions to eliminate foreign substances through the epidermis to the epidermal surface; this process is called transepidermal elimination (TEE). TEE has been observed in various skin tumors. We encountered a 64-year-old male patient with eccrine poroma with marked TEE. A dark brown nodular papule appeared on the anterior aspect of his right leg about 20 years ago and gradually expanded. Histopathologically, cell nests of poroma were extruded to the epidermal surface at several sites. No erosion was noted, and mild to moderate inflammatory cell infiltration was observed in the upper layer of the dermis. According to Mehregan's classification, the TEE, phenomenon observed in our case may correspond to types 2 and 3. AD - Department of Pathology, Shizuoka General Hospital, Japan. FAU - Arai, K AU - Arai K FAU - Fujita, H AU - Fujita H FAU - Suzuki, M AU - Suzuki M FAU - Iwasaki, K AU - Iwasaki K LA - eng PT - Case Reports PT - Journal Article PL - JAPAN TA - J Dermatol JID - 7600545 SB - IM MH - Acrospiroma, Eccrine/diagnosis/*pathology/physiopathology MH - Diagnosis, Differential MH - Epidermis/*metabolism/pathology MH - Human MH - Male MH - Middle Aged MH - Remission, Spontaneous MH - Sweat Gland Neoplasms/diagnosis/*pathology/physiopathology EDAT- 1997/09/25 MHDA- 1997/09/25 00:01 PST - ppublish SO - J Dermatol 1997 Aug;24(8):539-42. PMID- 9261471 OWN - NLM STAT- completed DA - 19971006 DCOM- 19971006 LR - 20031114 IS - 0193-1091 VI - 19 IP - 4 DP - 1997 Aug TI - Primary metaplastic carcinoma (carcinosarcoma) of the skin. A clinicopathologic study of four cases and review of the literature. PG - 363-72 AB - Metaplastic carcinoma (carcinosarcoma, sarcomatoid carcinoma, malignant mixed tumor) is a biphasic tumor comprising malignant epithelial and heterologous mesenchymal elements. Primary cutaneous cases are rare, with only seven cases documented in the English literature to date. We present four further cases, including three that developed in association with squamous cell carcinoma and one in an eccrine porocarcinoma. Heterologous malignant mesenchymal elements included malignant osteosarcoma, chondrosarcoma, leiomyosarcoma, and rhabdomyosarcomas. In contrast to metaplastic carcinomas arising in visceral sites, those primarily arising in the skin do not appear to behave in a very aggressive manner (Recurrence rate 22%, metastasis rate 22%, overall mortality 11%). However, the numbers involved are small and the follow-up period is short. In view of recent developments and progress in our understanding of the possible histogenesis of such tumors, we suggest that metaplastic carcinoma rather than carcinosarcoma is the most appropriate term with which to describe these very rare cutaneous neoplasms. AD - Department of Histopathology, St John's Institute of Dermatology, UMDS (St Thomas's campus), London, England. FAU - Patel, N K AU - Patel NK FAU - McKee, P H AU - McKee PH FAU - Smith, N P AU - Smith NP FAU - Fletcher, C D AU - Fletcher CD LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review of Reported Cases PL - UNITED STATES TA - Am J Dermatopathol JID - 7911005 SB - IM MH - Acrospiroma, Eccrine/pathology MH - Aged MH - Aged, 80 and over MH - Carcinoma, Squamous Cell/pathology MH - Carcinosarcoma/*pathology/secondary MH - Cell Nucleolus/ultrastructure MH - Cell Nucleus/ultrastructure MH - Chondrosarcoma/pathology MH - Cytoplasm/ultrastructure MH - Diagnosis, Differential MH - Epithelium/pathology MH - Facial Neoplasms/pathology MH - Follow-Up Studies MH - Human MH - Leiomyosarcoma/pathology MH - Male MH - Mesoderm/pathology MH - Metaplasia MH - Neoplasm Recurrence, Local MH - Neoplasms, Multiple Primary/pathology MH - Osteosarcoma/pathology MH - Rhabdomyosarcoma/pathology MH - Scalp/pathology MH - Skin Neoplasms/*pathology MH - Survival Rate MH - Sweat Gland Neoplasms/pathology RF - 24 EDAT- 1997/08/01 MHDA- 1997/08/01 00:01 PST - ppublish SO - Am J Dermatopathol 1997 Aug;19(4):363-72. PMID- 9261469 OWN - NLM STAT- completed DA - 19971006 DCOM- 19971006 LR - 20031114 IS - 0193-1091 VI - 19 IP - 4 DP - 1997 Aug TI - Clear cell hidradenoma associated with the folliculo-sebaceous-apocrine unit. Histologic study of five cases. PG - 351-7 AB - Hidradenomas are benign adnexal neoplasms of uncertain derivation. Although most investigators traditionally have considered these neoplasms to exhibit eccrine differentiation, with only occasional reports supporting apocrine derivation, subdivision of hidradenomas into two groups was recently suggested: those with eccrine differentiation (or poroid hidradenomas) and those exhibiting apocrine differentiation (or clear cell hidradenomas). We have observed five cases of clear cell hidradenomas manifesting unquestionable apocrine characteristics excised from sites other than the axilla, and displaying continuity with the epidermis through follicles. Because of the common embryologic derivation of apocrine glands, sebaceous glands, and hair follicles, and their histologic integration as the folliculo-sebaceous-apocrine unit, these findings suggest a possible origin of certain apocrine hidradenomas from pluripotential germinative cells present in follicles. AD - Istituto di Scienze Dermatologiche, Universita degli Studi di Milano, IRCCS, Ospedale Maggiore, Italy. FAU - Gianotti, R AU - Gianotti R FAU - Alessi, E AU - Alessi E LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Am J Dermatopathol JID - 7911005 RN - 0 (CA-15-3 Antigen) RN - 0 (Carcinoembryonic Antigen) RN - 0 (Mucins) RN - 0 (S100 Proteins) RN - 9005-79-2 (Glycogen) RN - 9007-34-5 (Collagen) SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Adult MH - Apocrine Glands/embryology/*pathology MH - Back MH - CA-15-3 Antigen/analysis MH - Carcinoembryonic Antigen/analysis MH - Cell Differentiation MH - Cell Nucleus/ultrastructure MH - Collagen/analysis MH - Cytoplasm/ultrastructure MH - Epidermis/pathology MH - Epithelium/pathology MH - Female MH - Glycogen/analysis MH - Hair Follicle/embryology/*pathology MH - Human MH - Male MH - Middle Aged MH - Mucins/analysis MH - Neck MH - S100 Proteins/analysis MH - Scalp MH - Scapula MH - Sebaceous Glands/embryology/*pathology MH - Stem Cells/pathology MH - Sweat Gland Neoplasms/*pathology EDAT- 1997/08/01 MHDA- 1997/08/01 00:01 PST - ppublish SO - Am J Dermatopathol 1997 Aug;19(4):351-7. PMID- 9236878 OWN - NLM STAT- completed DA - 19970825 DCOM- 19970825 LR - 20031114 IS - 1076-0512 VI - 23 IP - 7 DP - 1997 Jul TI - Eccrine porocarcinoma. PG - 583-4 AB - Eccrine porocarcinoma is a malignant tumor of eccrine sweat glands. It is a very rare, slow growing tumor and clinically resembles other skin cancers. We report a case and review its clinical and pathological features. These tumors have a propensity for local recurrence, and wide excision with negative margins is recommended. AD - Department of Surgery, Bronx-Lebanon Hospital Center, New York 10457, USA. FAU - Girishkumar, H AU - Girishkumar H FAU - Kamineni, S AU - Kamineni S FAU - Hwang, R R AU - Hwang RR FAU - Levy, J AU - Levy J FAU - Sadler, R AU - Sadler R LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Dermatol Surg JID - 9504371 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Adult MH - Eccrine Glands/pathology MH - Female MH - Human MH - Sweat Gland Neoplasms/*pathology EDAT- 1997/07/01 MHDA- 1997/07/01 00:01 AID - S1076051297001350 [pii] PST - ppublish SO - Dermatol Surg 1997 Jul;23(7):583-4. PMID- 9178800 OWN - NLM STAT- completed DA - 19970627 DCOM- 19970627 LR - 20031114 IS - 0020-7136 VI - 71 IP - 4 DP - 1997 May 16 TI - Dysregulated expression of transforming growth factor beta and its type-I and type-II receptors in basal-cell carcinoma. PG - 505-9 AB - In mammals, transforming growth factor-beta (TGF-beta) is found in 3 highly homologous isoforms that exert their effects via heteromeric complexes of type-I and type-II receptors (TbetaR-I and TbetaR-II). TGF-beta regulates the growth and metabolism of various cell types, including keratinocytes. We have investigated the immunohistological localization of TGF-beta1, TGF-beta2, TbetaR-I and TbetaR-II in normal human skin, basal-cell carcinoma (BCC), Bowen's disease, seborrheic keratosis, eccrine poroma and eccrine spiradenoma using frozen tissue specimens. In normal human skin, the immunoreactive TGF-beta2, but not TGF-beta1, was detected predominantly in the epidermis, follicles and sebaceous glands. The epidermal expression of TbetaR-I and TbetaR-II was very weak in the majority of normal skins. In BCC, TGF-beta2 expression was markedly reduced or completely negative. In addition, TbetaR-I- and TbetaR-II-positive stromal cells were accumulated in the fibrotic stroma in some BCCs. These stromal cells were partly but moderately positive for TGF-beta1. Decreased expression of TGF-beta2 was likely to be associated with the differentiation state of BCC cells, since TGF-beta2 expression was clearly observed in the squamoid foci of BCC. In addition, no expression of TGF-beta2 was detected in the eccrine secretory portion or in eccrine spiradenoma, but it was detected in the upper eccrine ducts and in eccrine poroma. AD - Department of Dermatology, University of Tokyo, Branch Hospital, Bunkyo-ku, Japan. FURUEM-DIS@h.u-tokyo.ac.jp FAU - Furue, M AU - Furue M FAU - Kato, M AU - Kato M FAU - Nakamura, K AU - Nakamura K FAU - Nashiro, K AU - Nashiro K FAU - Kikuchi, K AU - Kikuchi K FAU - Okochi, H AU - Okochi H FAU - Miyazono, K AU - Miyazono K FAU - Tamaki, K AU - Tamaki K LA - eng PT - Journal Article PL - UNITED STATES TA - Int J Cancer JID - 0042124 RN - 0 (Neoplasm Proteins) RN - 0 (Receptors, Transforming Growth Factor beta) RN - 0 (Transforming Growth Factor beta) RN - 0 (transforming growth factor-beta type II receptor) RN - EC 2.7.1.- (TGF-beta type I receptor) RN - EC 2.7.1.37 (Activin Receptors, Type I) RN - EC 2.7.1.37 (Protein-Serine-Threonine Kinases) SB - IM MH - Acrospiroma, Eccrine/genetics/metabolism MH - *Activin Receptors, Type I MH - Adenoma, Sweat Gland/genetics/metabolism MH - Amino Acid Sequence MH - Bowen's Disease/genetics/metabolism MH - Carcinoma, Basal Cell/genetics/*metabolism MH - Comparative Study MH - *Gene Expression Regulation, Neoplastic MH - Human MH - Keratosis, Seborrheic/genetics/metabolism MH - Molecular Sequence Data MH - Neoplasm Proteins/*biosynthesis/genetics MH - Protein-Serine-Threonine Kinases/*biosynthesis/genetics MH - Receptors, Transforming Growth Factor beta/*biosynthesis/genetics MH - Skin/metabolism MH - Skin Neoplasms/genetics/*metabolism/pathology MH - Support, Non-U.S. Gov't MH - Sweat Gland Neoplasms/genetics/metabolism MH - Transforming Growth Factor beta/*biosynthesis/genetics EDAT- 1997/05/16 MHDA- 2000/06/20 09:00 AID - 10.1002/(SICI)1097-0215(19970516)71:4<505::AID-IJC1>3.0.CO;2-Y [pii] PST - ppublish SO - Int J Cancer 1997 May 16;71(4):505-9. PMID- 9195464 OWN - NLM STAT- completed DA - 19970731 DCOM- 19970731 LR - 20031114 IS - 0363-5023 VI - 22 IP - 3 DP - 1997 May TI - Malignant eccrine poroma of the hand: a case report. PG - 511-4 AB - Carcinoma of sweat glands is a very rare neoplasm that is difficult to diagnose clinically and histologically. This report presents a case of malignant eccrine poroma of the hand which is a distinct histologic subtype of sweat gland carcinoma with a high local recurrence rate. A distal radial artery based forearm flap was used to provide soft tissue coverage. AD - Department of Orthopaedics, Brown University School of Medicine, Rhode Island Hospital, Providence, USA. FAU - DaSilva, M F AU - DaSilva MF FAU - Terek, R AU - Terek R FAU - Weiss, A P AU - Weiss AP LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - J Hand Surg [Am] JID - 7609631 SB - IM MH - Acrospiroma, Eccrine/pathology/*surgery MH - Diagnosis, Differential MH - Female MH - Forearm/blood supply MH - *Hand MH - Human MH - Middle Aged MH - Neoplasm Recurrence, Local/pathology/*surgery MH - Surgical Flaps MH - Sweat Gland Neoplasms/pathology/*surgery EDAT- 1997/05/01 MHDA- 1997/05/01 00:01 PST - ppublish SO - J Hand Surg [Am] 1997 May;22(3):511-4. PMID- 9184452 OWN - NLM STAT- completed DA - 19970624 DCOM- 19970624 LR - 20031114 IS - 0021-5287 VI - 88 IP - 5 DP - 1997 May TI - [A case of porocarcinoma arising on the penile shaft] PG - 576-9 AB - BACKGROUND: Porocarcinoma is a rare eccrine sweat gland tumor, and a varied treatment is not yet determined for metastatic disease because of the chemo-resistant and radio-resistant nature of this tumor. CASE: This report describes a case of porocarcinoma arising on the penile shaft of 83-year-old man with extensive lymph node metastases. He was treated with emasculation and bilateral ilio-inguinal lymph node dissection. Histological examination of the resected tumor showed a homogeneous round cells with duct-like formation in some part and Pagetoid infiltration was also noted in the dermis. Immunohistochemical examination demonstrated a positive CEA and negative S-100 staining and this result was consistent with the pathological diagnosis of porocarcinoma. One course of chemotherapy which consisted of methotrexate, cisplatin, adriamycin, and bleomycin was given to the patient following surgery for the treatment of residual lymph nodes in the paraaortic area. Abdominal CT scan revealed partial response, about -94% shrinkage, after one course of chemotherapy. The duration of the response lasted four 4 months. He died of pneumonia caused by MRSA after 4 months and the autopsy revealed multiple liver metastases and a massive infiltration of tumor cells in the bone marrow of lumbar vertebra. CONCLUSIONS: There is no definite treatment modality available for metastatic porocarcinoma. Because of the patient's age, only one course of chemotherapy was given, however, a fairly good response against this rare tumor suggested that this new regimen might be effective against porocarcinoma. AD - Department of Urology, Jichi Medical School, Tochigi, Japan. FAU - Muraki, J AU - Muraki J FAU - Sugaya, Y AU - Sugaya Y FAU - Hashimoto, S AU - Hashimoto S FAU - Morita, T AU - Morita T FAU - Kobayashi, Y AU - Kobayashi Y FAU - Tokue, A AU - Tokue A FAU - Kawai, T AU - Kawai T LA - jpn PT - Case Reports PT - Journal Article PL - JAPAN TA - Nippon Hinyokika Gakkai Zasshi JID - 2984841R RN - 0 (Antineoplastic Combined Chemotherapy Protocols) SB - IM MH - Acrospiroma, Eccrine/drug therapy/*pathology/surgery MH - Aged MH - Aged, 80 and over MH - Antineoplastic Combined Chemotherapy Protocols/therapeutic use MH - Combined Modality Therapy MH - English Abstract MH - Human MH - Male MH - Penile Neoplasms/drug therapy/*pathology/surgery EDAT- 1997/05/01 MHDA- 1997/05/01 00:01 PST - ppublish SO - Nippon Hinyokika Gakkai Zasshi 1997 May;88(5):576-9. PMID- 9149793 OWN - NLM STAT- completed DA - 19970527 DCOM- 19970527 LR - 20031114 IS - 1076-0512 VI - 23 IP - 4 DP - 1997 Apr TI - Malignant metastatic eccrine poroma. Proposal for a new therapeutic protocol. PG - 267-72 AB - BACKGROUND: Malignant metastatic eccrine poroma is a very rare cutaneous neoplasm, and consequently the references in the literature regarding the treatment of this tumor, known also as porocarcinoma, are very poor. OBJECTIVE: To call attention to a new therapeutic protocol in the treatment of metastatic porocarcinoma, as well as to underline an antineoplastic efficacy of vitamin A analogues. METHODS: The results are presented on the basis of the clinical case of a malignant eccrine poroma with metastatic regional lymph nodes. RESULTS: With our new chemotherapeutic protocol, arrest of the metastatic progression was achieved after 3 months and the remission was maintained until the 10th month of therapy. CONCLUSIONS: A new chemotherapy protocol consisting of isotretinoin and interferon alpha has confirmed the advantages of polychemotherapy in the treatment of metastatic malignant eccrine poroma. On the basis of the considerably long, although incomplete, remission with good drug tolerance in spite of the high doses used as well as the undoubtedly major antineoplastic strength of the latest generation of synthetic retinoids, we feel that these findings could be a good starting point for further experimental verifications of the therapy of this aggressive cutaneous neoplasm. AD - Department of Plastic and Reconstructive Surgery, Clinica Santa Famiglia, Rome, Italy. FAU - Barzi, A S AU - Barzi AS FAU - Ruggeri, S AU - Ruggeri S FAU - Recchia, F AU - Recchia F FAU - Bertoldi, I AU - Bertoldi I LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review of Reported Cases PL - UNITED STATES TA - Dermatol Surg JID - 9504371 SB - IM MH - *Acrospiroma, Eccrine/pathology/surgery MH - *Buttocks MH - Female MH - Human MH - Middle Aged MH - *Sweat Gland Neoplasms/pathology/surgery RF - 30 EDAT- 1997/04/01 MHDA- 1997/04/01 00:01 AID - S1076051297001039 [pii] PST - ppublish SO - Dermatol Surg 1997 Apr;23(4):267-72. PMID- 9138117 OWN - NLM STAT- completed DA - 19970702 DCOM- 19970702 LR - 20001218 IS - 0303-6987 VI - 24 IP - 4 DP - 1997 Apr TI - Differentiation of eccrine poroma cells to cytokeratin 1- and 10-expressing cells, the intermediate layer cells of eccrine sweat duct, in the tumor cell nests. PG - 246-8 AB - It has been shown that an intermediate cell layer exists between a luminal cell layer and a peripheral cell layer in human eccrine sweat ducts by immunohistochemistry using anti-keratin antibodies 34 beta B4 and DE-K10. These antibodies react to cytokeratin 1 and 10 respectively, and stain the intermediate cells specifically, but not luminal cells nor peripheral cells. Cytokeratin 1 and 10 are considered to appear as a differentiated keratin in the terminal process of epidermal keratinization. We examined 5 cases of eccrine poroma with 34 beta B4 and DE-K10. Various numbers of the poroid cells reacted to these anti-keratin antibodies in 4 cases. Some positive cells were observed around the cuticular cells in two of them. The present study demonstrated that terminal differentiation in terms of keratinization can occur in eccrine poromas, and that the 34 beta B4- and DE-K10-positive cells around the cuticular cells differentiate toward the intermediate cells in cytokeratin expression profile and location. AD - Department of Dermatology, Hashima City Hospital, Japan. FAU - Ban, M AU - Ban M FAU - Yoneda, K AU - Yoneda K FAU - Kitajima, Y AU - Kitajima Y LA - eng PT - Journal Article PL - DENMARK TA - J Cutan Pathol JID - 0425124 RN - 0 (Antibodies, Monoclonal) RN - 68238-35-7 (Keratin) SB - IM MH - Acrospiroma, Eccrine/chemistry/metabolism/*pathology MH - Antibodies, Monoclonal MH - Cell Differentiation MH - Eccrine Glands/anatomy & histology/chemistry/*metabolism MH - Epidermis/anatomy & histology/chemistry MH - Histocytochemistry MH - Human MH - Keratin/*biosynthesis/immunology MH - Staining and Labeling MH - Sweat Gland Neoplasms/chemistry/metabolism/*pathology EDAT- 1997/04/01 MHDA- 1997/04/01 00:01 PST - ppublish SO - J Cutan Pathol 1997 Apr;24(4):246-8. PMID- 9031022 OWN - NLM STAT- completed DA - 19970328 DCOM- 19970328 LR - 20031114 IS - 1067-2516 VI - 36 IP - 1 DP - 1997 Jan-Feb TI - Clear cell hidradenoma of the second digit: a review of the literature with case presentation. PG - 21-3 AB - Clear cell hidradenoma is a well circumscribed and often encapsulated benign tumor of the dermis and subcutaneous tissue. These tumors have a low tendency toward ulceration, may vary in size, and have a low malignant potential. The treatment of choice is usually surgical excision. A literature review of this soft tissue tumor and a case history are presented. AD - Section of Podiatric Medicine and Surgery, VA Connecticut Healthcare System, Yale University, School of Medicine Clinical Campus, West Haven, USA. FAU - Feldman, A H AU - Feldman AH FAU - Niemi, W J AU - Niemi WJ FAU - Blume, P A AU - Blume PA FAU - Chaney, D M AU - Chaney DM LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review, Tutorial PL - UNITED STATES TA - J Foot Ankle Surg JID - 9308427 SB - IM MH - *Acrospiroma, Eccrine/etiology/pathology/surgery MH - *Foot Diseases/etiology/pathology/surgery MH - Human MH - Male MH - Middle Aged MH - *Sweat Gland Neoplasms/etiology/pathology/surgery MH - Toes MH - Wounds and Injuries/complications RF - 7 EDAT- 1997/01/01 MHDA- 1997/01/01 00:01 PST - ppublish SO - J Foot Ankle Surg 1997 Jan-Feb;36(1):21-3. PMID- 9027630 OWN - NLM STAT- completed DA - 19970415 DCOM- 19970415 LR - 20001218 IS - 0303-6987 VI - 24 IP - 1 DP - 1997 Jan TI - Histogenesis of clear cell hidradenoma: immunohistochemical study of keratin expression. PG - 30-6 AB - The expression of cytokeratins in 10 cases of clear cell hidradenoma, including 3 cases of solid cystic hidradenoma, were examined using 21 kinds of monoclonal antibodies. We divided them into three histologic patterns: massive nests with a few lumina (M nests), nests with some tubular lumina (L nests), and nests in solid cystic hidradenomas (S nests). All hidradenomas showed similar immunoreactivities to those in the lower dermal ducts or secretory cells of normal eccrine glands. With antibodies against simple epithelial cytokeratins (CKs 7, 8, 18, and 19), however, different immunostaining was noted among the three histologic patterns. Namely, the M nests failed to react to them, although some luminal cells in the L nests revealed a positive staining. Furthermore, a majority of luminal cells in the S nests revealed a positive staining with them. Therefore, we think that the luminal cells in solid cystic hidradenoma mainly differentiate toward the secretory cells, and that the M nests mainly differentiate toward the dermal duct. Those in the L nests are thought to differentiate toward the dermal duct and the secretory cells. The proportion of the differentiation toward luminal cells of dermal ducts to the differentiation toward secretory cells was the main difference among the three nests. In addition, there was no difference in immunophenotypes between clear cells and epidermoid cells in the two kinds of hidradenomas. AD - Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan. FAU - Ohnishi, T AU - Ohnishi T FAU - Watanabe, S AU - Watanabe S LA - eng PT - Journal Article PL - DENMARK TA - J Cutan Pathol JID - 0425124 RN - 68238-35-7 (Keratin) SB - IM MH - Acrospiroma, Eccrine/metabolism/*pathology MH - Human MH - Immunohistochemistry MH - Keratin/*biosynthesis/chemistry MH - Retrospective Studies MH - Skin Neoplasms/metabolism/*pathology EDAT- 1997/01/01 MHDA- 1997/01/01 00:01 PST - ppublish SO - J Cutan Pathol 1997 Jan;24(1):30-6. PMID- 9013071 OWN - NLM STAT- completed DA - 19970401 DCOM- 19970401 LR - 20031114 IS - 0011-4162 VI - 59 IP - 1 DP - 1997 Jan TI - Pigmented sweat gland tumor mimicking melanoma. PG - 43-6 AB - Eccrine poroma, a common adnexal neoplasm, usually presents as a solitary, smooth, flesh-colored nodule on the foot or hand. Eccrine porocarcinoma is extremely rare and much more variable in its morphology and location. Both tumors can contain melanocytes and melanin. We describe a patient with an enlarging, eroded brownish black nodule on his shoulder. Examination of a biopsy specimen showed it to be derived from acrosyringium and to contain abundant melanin and scattered dendritic melanocytes. Eccrine poroma and porocarcinoma should be considered in the clinical differential diagnosis of pigmented tumors. AD - SUNY Health Science at Brooklyn, USA. FAU - Roaf, V AU - Roaf V FAU - Chin, N AU - Chin N FAU - Lynfield, Y AU - Lynfield Y LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Cutis JID - 0006440 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Diagnosis, Differential MH - Human MH - Male MH - Melanoma/*pathology MH - Middle Aged MH - Skin Neoplasms/*pathology MH - Sweat Gland Neoplasms/*pathology EDAT- 1997/01/01 MHDA- 1997/01/01 00:01 PST - ppublish SO - Cutis 1997 Jan;59(1):43-6. PMID- 9078309 OWN - NLM STAT- completed DA - 19970410 DCOM- 19970410 LR - 20031114 IS - 1076-0512 VI - 22 IP - 12 DP - 1996 Dec TI - Stump the experts. Eccrine acrospiroma, clear cell type. PG - 998, 1069 AD - Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA. FAU - Dumont, K M AU - Dumont KM FAU - Humphreys, T R AU - Humphreys TR FAU - Malhotra, R AU - Malhotra R LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Dermatol Surg JID - 9504371 SB - IM MH - Acrospiroma, Eccrine/*diagnosis/pathology MH - Diagnosis, Differential MH - Human MH - Male MH - Middle Aged MH - Sweat Gland Neoplasms/*diagnosis/pathology EDAT- 1996/12/01 MHDA- 1996/12/01 00:01 AID - S1076051297000046 [pii] PST - ppublish SO - Dermatol Surg 1996 Dec;22(12):998, 1069. PMID- 9007142 OWN - NLM STAT- completed DA - 19970219 DCOM- 19970219 LR - 20031114 IS - 0021-2180 VI - 32 IP - 12 DP - 1996 Dec TI - Benign and malignant eccrine poroma--a flow cytometric comparison. PG - 1151-3 AB - Eccrine poroma is a benign, slow growing, solitary adnexal tumor. Malignant degeneration may take place in longstanding solitary lesions; in such cases cutaneous and fatal visceral metastases have occurred. Our goal was to determine whether flow cytometry yields useful diagnostic and prognostic information on benign and malignant eccrine poroma. Flow cytometric analysis of the nuclear DNA ploidy pattern was performed on four samples of eccrine poroma and five samples of malignant eccrine poroma. All the histograms of the eccrine poromas were diploid. Two of five specimens (40%) of the eccrine porocarcinoma were aneuploid, and the other three (60%) were diploid. The diploid pattern represents another expression of the benignancy of eccrine poroma. Since abnormal DNA content is often correlated with tumor grade, the aneuploid DNA histogram of 40% of the patients with malignant eccrine poroma is not a surprising finding in this cytologically malignant neoplasm. AD - Department of Dermatology, Rabin Medical Center, Petah Tikva, Israel. FAU - Hagler, J AU - Hagler J FAU - Trattner, A AU - Trattner A FAU - Nativ, O AU - Nativ O FAU - Hauben, D J AU - Hauben DJ FAU - David, M AU - David M LA - eng PT - Journal Article PL - ISRAEL TA - Isr J Med Sci JID - 0013105 RN - 0 (DNA, Neoplasm) SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Age Distribution MH - Aged MH - Cell Transformation, Neoplastic/*pathology MH - Comparative Study MH - DNA, Neoplasm/*analysis MH - Diagnosis, Differential MH - Female MH - Flow Cytometry/*standards MH - Human MH - Male MH - Middle Aged MH - *Ploidies MH - Prognosis MH - Reproducibility of Results MH - Sweat Gland Neoplasms/*pathology EDAT- 1996/12/01 MHDA- 1996/12/01 00:01 PST - ppublish SO - Isr J Med Sci 1996 Dec;32(12):1151-3. PMID- 9001989 OWN - NLM STAT- completed DA - 19970320 DCOM- 19970320 LR - 20031114 IS - 0303-6987 VI - 23 IP - 6 DP - 1996 Dec TI - Malignant eccrine poroma with multiple visceral metastases: report of a case with autopsy findings. PG - 566-70 AB - An autopsy case of malignant eccrine poroma (MEP) with multiple visceral metastases is reported. A flat, dark tumor of 1 cm in diameter developed on a pre-existing pigmented spot at the left side of the waist of a 58-year-old male. The histopathology suggested the tumor to be malignant melanoma. Nine years later, a painless swelling occurred in the left lower leg, resulting from the obstruction of lymphatics at the left inguinal region. The swelling continued and spread with pain, reaching the inguinal region. Two years later, several papules appeared around the left knee, from which an extensive lymphorrhea occurred. The histopathology of the resected papules suggested epidermoid carcinoma or trichilemmal carcinoma, mainly localized within the lymphatics of the upper dermis. Re-examination of the first skin tumor and electron microscopy of the tumor obtained at autopsy revealed that both tumors were MEP. Although the metastases to the local cutaneous regions and lymph nodes via the lymphatics occur in 20% of MEP, cases with multiple visceral metastases are very few. AD - Department of Pathology, Osaka Medical College, Japan. FAU - Maeda, T AU - Maeda T FAU - Mori, H AU - Mori H FAU - Matsuo, T AU - Matsuo T FAU - Nakagawa, J AU - Nakagawa J FAU - Yamauchi, H AU - Yamauchi H FAU - Tuziguchi, H AU - Tuziguchi H FAU - Hongou, Y AU - Hongou Y LA - eng PT - Case Reports PT - Journal Article PL - DENMARK TA - J Cutan Pathol JID - 0425124 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Autopsy MH - Diagnosis, Differential MH - Human MH - Male MH - Middle Aged MH - Neoplasm Metastasis MH - Sweat Gland Neoplasms/*pathology MH - Viscera/pathology EDAT- 1996/12/01 MHDA- 1996/12/01 00:01 PST - ppublish SO - J Cutan Pathol 1996 Dec;23(6):566-70. PMID- 8934076 OWN - NLM STAT- completed DA - 19970304 DCOM- 19970304 LR - 20031114 IS - 0011-4162 VI - 58 IP - 5 DP - 1996 Nov TI - Acrospiroma: a case report and review. PG - 349-51 AB - Acrospiromas are cutaneous tumors of sweat duct differentiation. They usually present as slowly enlarging 1 to 2 cm nodules in middle-aged or older adults without site predilection. On histologic examination they are multilobular dermal masses composed of a biphasic cell population. Acrospiromas are benign, and treatment consists of surgical excision. AD - Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas 78234-6200, USA. FAU - Laws, R A AU - Laws RA FAU - English, J C 3rd AU - English JC 3rd FAU - Elston, D M AU - Elston DM LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review Literature PL - UNITED STATES TA - Cutis JID - 0006440 SB - IM MH - Acrospiroma, Eccrine/*pathology/ultrastructure MH - Aged MH - Aged, 80 and over MH - Human MH - Male MH - Sweat Gland Neoplasms/*pathology/ultrastructure RF - 6 EDAT- 1996/11/01 MHDA- 2001/03/28 10:01 PST - ppublish SO - Cutis 1996 Nov;58(5):349-51. PMID- 8912607 OWN - NLM STAT- completed DA - 19961217 DCOM- 19961217 LR - 20031114 IS - 0190-9622 VI - 35 IP - 5 Pt 2 DP - 1996 Nov TI - Metastasizing eccrine porocarcinoma: report of a case and review of the literature. PG - 860-4 AB - Eccrine porocarcinoma is a rare malignant tumor arising from the intraepidermal ductal portion of the eccrine sweat gland (acrosyringium). It usually affects older persons and is located most commonly on the lower extremities. We describe a 55-year-old man with an aggressive metastasizing eccrine porocarcinoma diagnosed 10 years after the primary lesion. The metastatic lesions were located in the public area and scrotum and were associated with progressive lymphedema. Several biopsy specimens revealed numerous tumor cells in the dermis and especially in the lumina of lymph and blood vessels. Immunohistochemical studies showed staining with cytokeratin KL1, epithelial membrane antigen, Ca 15-3, and Ca 19-9. Vimentin, S-100 protein, neuron specific enolase, and carcino-embryonic antigen were negative. Treatment with carbon dioxide laser failed. The use of interferon alfa-2a for 9 months stopped progression of the tumor. AD - Department of Dermatology, University Hospital of Caremeau, Nimes, France. FAU - Huet, P AU - Huet P FAU - Dandurand, M AU - Dandurand M FAU - Pignodel, C AU - Pignodel C FAU - Guillot, B AU - Guillot B LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review of Reported Cases PL - UNITED STATES TA - J Am Acad Dermatol JID - 7907132 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Genital Neoplasms, Male/*secondary MH - Human MH - Male MH - Middle Aged MH - Support, Non-U.S. Gov't MH - Sweat Gland Neoplasms/*pathology RF - 55 EDAT- 1996/11/01 MHDA- 1996/11/01 00:01 PST - ppublish SO - J Am Acad Dermatol 1996 Nov;35(5 Pt 2):860-4. PMID- 8812539 OWN - NLM STAT- completed DA - 19961105 DCOM- 19961105 LR - 20031114 IS - 0090-8258 VI - 62 IP - 3 DP - 1996 Sep TI - Vulvar eccrine porocarcinoma. PG - 396-9 AB - A rare case of a slowly growing vulvar tumor in a 75-year-old woman is presented. This vulvar neoplasm was an eccrine porocarcinoma with left inguinal nodal metastases. This is believed to be only the second reported case of a vulvar eccrine porocarcinoma. Treatment included a left hemivulvectomy, bilateral inguinal-femoral lymphadenectomy, and postoperative radiation therapy. A review of the literature regarding this unusual malignancy is included. AD - Department of Obstetrics and Gynecology, University of Louisville School of Medicine, Kentucky 40202, USA. FAU - Katsanis, W A AU - Katsanis WA FAU - Doering, D L AU - Doering DL FAU - Bosscher, J R AU - Bosscher JR FAU - O'Connor, D M AU - O'Connor DM LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review of Reported Cases PL - UNITED STATES TA - Gynecol Oncol JID - 0365304 SB - IM MH - Acrospiroma, Eccrine/*diagnosis/epidemiology/therapy MH - Aged MH - Female MH - Groin MH - Human MH - Lymph Node Excision MH - Radiotherapy, Adjuvant MH - Thigh MH - Vulva/surgery MH - Vulvar Neoplasms/*diagnosis/epidemiology/therapy RF - 21 EDAT- 1996/09/01 MHDA- 1996/09/01 00:01 AID - S0090825896902553 [pii] PST - ppublish SO - Gynecol Oncol 1996 Sep;62(3):396-9. PMID- 8756368 OWN - NLM STAT- completed DA - 19960913 DCOM- 19960913 LR - 20031114 IS - 0008-543X VI - 78 IP - 4 DP - 1996 Aug 15 TI - Porocarcinoma of the heel. A case report with unusual histologic features. PG - 751-7 AB - BACKGROUND. Eccrine porocarcinoma is an uncommon neoplasm of the intraepidermal sweat gland duct. METHODS. A case of porocarcinoma of the right heel in a male age 51 years is described with a review of pertinent literature. The surgically excised neoplasm was evaluated by routine histology and transmission electron microscopy. RESULTS. The porocarcinoma showed extensive nuclear pleomorphisms with frequent, multinucleated tumor giant cells, focal epidermotrophic spread within the epidermis, a peripheral, eccrine syringofibroadenoma-like growth pattern, and an origin in a contiguous eccrine poroma. Ultrastructurally, the squamous tumor cells contained rare intracytoplasmic lumens. CONCLUSIONS. The extensive nuclear pleomorphism with frequent tumor giant cells was an unusual feature of the porocarcinoma. Its epidermotrophic spread within the epidermis and its origin in a contiguous eccrine poroma supported the diagnosis of porocarcinoma. The eccrine syringofibroadenoma-like growth pattern in the periphery of the tumor was a unique and previously undescribed feature of the porocarcinoma. The presence of intracytoplasmic lumens in squamous tumor cells mimicked embryonic development of the intraepidermal sweat gland duct. AD - Department of Veterans Affairs Medical Center, Washington, DC 20422, USA. FAU - D'Amato, M S AU - D'Amato MS FAU - Patterson, R H AU - Patterson RH FAU - Guccion, J G AU - Guccion JG FAU - White, J C AU - White JC FAU - Krasnow, S H AU - Krasnow SH LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review Literature PL - UNITED STATES TA - Cancer JID - 0374236 SB - AIM SB - IM MH - Acrospiroma, Eccrine/*pathology/surgery MH - Biopsy MH - Carcinoma, Squamous Cell/*pathology/surgery MH - Cell Division/physiology MH - Heel/*pathology/surgery MH - Human MH - Male MH - Middle Aged MH - Skin Neoplasms/*pathology/surgery MH - Sweat Gland Neoplasms/*pathology/surgery RF - 27 EDAT- 1996/08/15 MHDA- 2000/06/20 09:00 AID - 10.1002/(SICI)1097-0142(19960815)78:4<751::AID-CNCR10>3.0.CO;2-U [pii] PST - ppublish SO - Cancer 1996 Aug 15;78(4):751-7. PMID- 8772026 OWN - NLM STAT- completed DA - 19961010 DCOM- 19961010 LR - 20031114 IS - 0385-2407 VI - 23 IP - 7 DP - 1996 Jul TI - Multiple malignant eccrine poroma and a linear epidermal nevus. PG - 469-71 AB - A 68-year-old woman developed three reddish nodules on a linear epidermal nevus on the right arm. The nodules and linear lesion were resected. The histology revealed the two larger nodules to be eccrine porocarcinoma and the other to be eccrine poroepithelioma. The linear lesion was actually epidermal nevus. To our knowledge, this is the first description of adnexal tumors developing on epidermal nevus. AD - Department of Dermatology, Yamaguchi Rosai Hospital, Tsukuba, Japan. FAU - Hamanaka, S AU - Hamanaka S FAU - Otsuka, F AU - Otsuka F LA - eng PT - Case Reports PT - Journal Article PL - JAPAN TA - J Dermatol JID - 7600545 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - Arm MH - Female MH - Human MH - Neoplasms, Multiple Primary/*pathology MH - Nevus/*pathology MH - Skin Neoplasms/*pathology MH - Sweat Gland Neoplasms/*pathology EDAT- 1996/07/01 MHDA- 1996/07/01 00:01 PST - ppublish SO - J Dermatol 1996 Jul;23(7):469-71. PMID- 8793662 OWN - NLM STAT- completed DA - 19961119 DCOM- 19961119 LR - 20031114 IS - 0303-6987 VI - 23 IP - 3 DP - 1996 Jun TI - Mucinous differentiation in adnexal sweat gland tumors. PG - 259-63 AB - We report an eccrine acrospiroma, on the cheek of a 29-year-old female, in which the presence of abundant mucinous (goblet cell) metaplasia closely mimicked a primary mucoepidermoid carcinoma. To determine the frequency of mucinous differentiation in benign adnexal sweat gland tumors, we evaluated sixty-five cases in hematoxylin and eosin stained sections for the presence of goblet cells and sixty of these for mucicarmine positivity. Goblet cell metaplasia was seen in 3 of 12 acrospiromas, 1 of 8 mixed tumors, and in 1 of 9 cases of syringocystadenoma papilliferum. All goblet cells were positive for mucicarmine, except in one case of acrospiroma, where goblet cells were not detected on the section stained with mucicarmine. In addition, intracellular mucin, inclusive of goblet cells, was seen in 5 of 12 acrospiromas, 1 of 11 poromas, 5 of 8 mixed tumors, 3 of 13 spiradenomas, 1 of 5 cylindromas, 3 of 9 cases of syringocystadenoma papilliferum and 1 of 3 nipple adenomas. The majority of the tumors had both extracellular mucicarmine positivity (40 of 60) and luminal mucicarmine positivity (39 of 60). We conclude that mucinous differentiation in sweat gland tumors, as defined by the presence of goblet cells and/or intracellular mucicarmine positivity, is common and does not indicate aggressive behavior. Mucinous differentiation in benign sweat gland tumors should not be confused with more aggressive mucoepidermoid carcinomas of salivary gland origin or adenosquamous carcinoma. AD - Dermatopathology Division, University of Tennessee Medical Center at Knoxville 37920, USA. FAU - Fitzgibbon, J F AU - Fitzgibbon JF FAU - Googe, P B AU - Googe PB LA - eng PT - Case Reports PT - Journal Article PL - DENMARK TA - J Cutan Pathol JID - 0425124 RN - 0 (Mucins) SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Adult MH - Cell Differentiation MH - Facial Neoplasms/*pathology MH - Female MH - Human MH - *Mucins MH - Sweat Gland Neoplasms/*pathology EDAT- 1996/06/01 MHDA- 1996/06/01 00:01 PST - ppublish SO - J Cutan Pathol 1996 Jun;23(3):259-63. PMID- 8634818 OWN - NLM STAT- completed DA - 19960708 DCOM- 19960708 LR - 20011126 IS - 1076-0512 VI - 22 IP - 5 DP - 1996 May TI - Eccrine spiradenoma, not poroma. PG - 484 FAU - Beckman, B AU - Beckman B LA - eng PT - Comment PT - Letter PL - UNITED STATES TA - Dermatol Surg JID - 9504371 SB - IM CON - Dermatol Surg. 1995 Nov;21(11):925, 997-8. PMID: 7582829 MH - Acrospiroma, Eccrine MH - *Adenoma, Sweat Gland MH - Human MH - *Sweat Gland Neoplasms MH - Terminology EDAT- 1996/05/01 MHDA- 1996/05/01 00:01 PST - ppublish SO - Dermatol Surg 1996 May;22(5):484. PMID- 8733404 OWN - NLM STAT- completed DA - 19961010 DCOM- 19961010 LR - 20031114 IS - 0007-0963 VI - 134 IP - 4 DP - 1996 Apr TI - Malignant eccrine poroma in a patient with Rothmund-Thomson syndrome. PG - 813-5 FAU - Van Hees, C L AU - Van Hees CL FAU - Van Duinen, C M AU - Van Duinen CM FAU - Bruijin, J A AU - Bruijin JA FAU - Vermeer, B J AU - Vermeer BJ LA - eng PT - Case Reports PT - Letter PL - ENGLAND TA - Br J Dermatol JID - 0004041 SB - IM MH - Acrospiroma, Eccrine/*etiology MH - Female MH - Human MH - Middle Aged MH - Poikiloderma Congenitale/*complications MH - Sweat Gland Neoplasms/*etiology EDAT- 1996/04/01 MHDA- 1996/04/01 00:01 PST - ppublish SO - Br J Dermatol 1996 Apr;134(4):813-5. PMID- 8732420 OWN - NLM STAT- completed DA - 19960918 DCOM- 19960918 LR - 20031114 IS - 0266-7681 VI - 21 IP - 2 DP - 1996 Apr TI - Recurrent eccrine acrospiroma of the hand. PG - 280-2 AD - Hospital for Special Surgery, New York, USA. FAU - Kalainov, D M AU - Kalainov DM FAU - DiCarlo, E F AU - DiCarlo EF FAU - Yang, S S AU - Yang SS FAU - Weiland, A J AU - Weiland AJ LA - eng PT - Case Reports PT - Journal Article PL - SCOTLAND TA - J Hand Surg [Br] JID - 8403839 SB - IM MH - Acrospiroma, Eccrine/pathology/*surgery MH - Adult MH - *Fingers MH - Human MH - Male MH - *Neoplasm Recurrence, Local MH - Sweat Gland Neoplasms/pathology/*surgery EDAT- 1996/04/01 MHDA- 1996/04/01 00:01 PST - ppublish SO - J Hand Surg [Br] 1996 Apr;21(2):280-2. PMID- 8629435 OWN - NLM STAT- completed DA - 19960621 DCOM- 19960621 LR - 20040109 IS - 0001-5547 VI - 40 IP - 2 DP - 1996 Mar-Apr TI - Cytologic findings in a case of malignant eccrine poroma. PG - 386-7 FAU - Lopez, J I AU - Lopez JI FAU - Rodil, M A AU - Rodil MA FAU - Ballestin, C AU - Ballestin C LA - eng PT - Case Reports PT - Letter PL - UNITED STATES TA - Acta Cytol JID - 0370307 RN - 0 (Antigens, CD15) RN - 0 (Intermediate Filament Proteins) RN - 0 (KRT20 protein, human) SB - IM MH - Acrospiroma, Eccrine/metabolism/*pathology MH - Aged MH - Aged, 80 and over MH - Antigens, CD15/metabolism MH - Female MH - Follow-Up Studies MH - Human MH - Intermediate Filament Proteins/metabolism MH - Sweat Gland Neoplasms/metabolism/*pathology EDAT- 1996/03/01 MHDA- 1996/03/01 00:01 PST - ppublish SO - Acta Cytol 1996 Mar-Apr;40(2):386-7. PMID- 8721584 OWN - NLM STAT- completed DA - 19961226 DCOM- 19961226 LR - 20031114 IS - 0193-1091 VI - 18 IP - 1 DP - 1996 Feb TI - Eccrine or apocrine poroma? Six poromas with divergent adnexal differentiation. PG - 1-9 AB - We describe six cases of benign eccrine poroma-like neoplasms with divergent adnexal differentiation. Four cases exhibited sebaceous differentiation in the form of individual or clustered sebocytes with or without sebaceous ducts. One case showed both sebaceous and hair follicle differentiation, and one case showed sebaceous and possible apocrine secretory differentiation. Clinically, most were skin-colored, red, or purple papules or nodules. One patient had a preoperative diagnosis of Bowen's disease, with an erythematous plaque. None recurred following biopsy. Previous reports of similar lesions have suggested a possible role for human papilloma virus (HPV) in their pathogenesis; however, immunohistochemical staining for HPV structural antigens was negative in all six of these cases. Similarities to previously reported cases of eccrine poroma-like neoplasms with sebaceous differentiation are discussed. Given the evidence of sebaceous and follicular differentiation seen in this study and the common embryologic origin of follicular, sebaceous, and apocrine structures, it follows that at least some benign neoplastic proliferations with histopathologic features of "eccrine" poroma could be of apocrine origin. AD - Department of Pathology, School of Medicine, University of California, San Francisco 94143-0506, USA. FAU - Harvell, J D AU - Harvell JD FAU - Kerschmann, R L AU - Kerschmann RL FAU - LeBoit, P E AU - LeBoit PE LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review of Reported Cases PL - UNITED STATES TA - Am J Dermatopathol JID - 7911005 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Adult MH - Aged MH - Cell Differentiation MH - Female MH - Human MH - Male MH - Middle Aged MH - Sebaceous Glands/*pathology MH - Skin Neoplasms/*pathology MH - Sweat Glands/*pathology RF - 30 EDAT- 1996/02/01 MHDA- 1996/02/01 00:01 PST - ppublish SO - Am J Dermatopathol 1996 Feb;18(1):1-9. PMID- 8815485 OWN - NLM STAT- completed DA - 19961010 DCOM- 19961010 LR - 20031114 IS - 0034-8376 VI - 48 IP - 1 DP - 1996 Jan-Feb TI - [Clear-cell eccrine carcinoma of the plantar region. Follow-up of a case using histochemistry, immunohistochemistry, and flow cytometry] PG - 43-8 AB - Clear cell eccrine carcinomas of the skin are rare and have been reported with several names. Of the 47 cases found in the literature, only one had the lesion in the sole. The present case is a 38 year old woman with an 18 year history of a 3.2 cm lesion in the lateral portion of the sole in the right foot. The patient developed inguinal metastases four and five months after the plantar resection, and suffered a local recurrence on two occasions. The histopathologic analysis of the sole lesion showed a neoplasm with more than 80% of clear cells, and less clear cells in the metastatic and recurrent lesions. Clear cells showed diffuse positivity to PAS with diastase lability. PAS reactivity was related to the presence of clear cells. Focal reactivity of mucin and colloidal iron in sebaceous-like cells and tubular structures was seen. Also, we found diffuse cytoplasmic and membrane surface positivity of epithelial membrane antigen in the clear cells, and focal in poroid and sebaceous cells and in tubular structures. The carcinoembryonic antigen showed a focal positivity in poroid and sebaceous cells and in tubular structures. We also identified focal positivity of S-100 protein in the sebaceous-like cells. Cytophotometric measurement of the nuclear DNA showed euploid cells in the primary and metastatic lesions. We conclude that clear cell eccrine carcinomas comprise a heterogeneous group of lesions with variable biological behavior, but with morphological, histochemical and immunohistochemical markers useful in their diagnosis. AD - Departamento de Patologia, Instituto Nacional de la Nutricion Salvador Zubiran, Mexico, D.F. FAU - Gamboa-Dominguez, A AU - Gamboa-Dominguez A FAU - Pichardo-Bahena, R AU - Pichardo-Bahena R FAU - Uribe Uribe, N O AU - Uribe Uribe NO FAU - Chew-Wong, A AU - Chew-Wong A FAU - Richaud-Patin, Y AU - Richaud-Patin Y FAU - Llorente, L AU - Llorente L FAU - Reyes-Gutierrez, E AU - Reyes-Gutierrez E LA - spa PT - Case Reports PT - Journal Article TT - Carcinoma ecrino de celulas claras en region plantar. Seguimiento de un caso por histoquimica, immunohistoquimica y citometria de flujo. PL - MEXICO TA - Rev Invest Clin JID - 9421552 SB - IM MH - Acrospiroma, Eccrine/*chemistry/genetics/pathology MH - Adult MH - English Abstract MH - Female MH - Flow Cytometry MH - Follow-Up Studies MH - Foot Diseases/genetics/*metabolism/pathology MH - Human MH - Immunoenzyme Techniques MH - Lymphatic Metastasis/pathology MH - Neoplasm Recurrence, Local/chemistry/pathology MH - Periodic Acid-Schiff Reaction MH - Sweat Gland Neoplasms/*chemistry/genetics/pathology EDAT- 1996/01/01 MHDA- 1996/01/01 00:01 PST - ppublish SO - Rev Invest Clin 1996 Jan-Feb;48(1):43-8. PMID- 8714269 OWN - NLM STAT- completed DA - 19961224 DCOM- 19961224 LR - 20031114 IS - 0031-3025 VI - 28 IP - 1 DP - 1996 Jan TI - Test and teach. Number Eighty. Diagnosis: Malignant eccrine poroma of scalp. PG - 39, 89 AD - Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong. FAU - Ng, W K AU - Ng WK LA - eng PT - Case Reports PT - Journal Article PL - ENGLAND TA - Pathology JID - 0175411 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Carcinoma/*pathology MH - Head and Neck Neoplasms/*pathology MH - Human MH - Male MH - Middle Aged MH - Sweat Gland Neoplasms/*pathology EDAT- 1996/01/01 MHDA- 1996/01/01 00:01 PST - ppublish SO - Pathology 1996 Jan;28(1):39, 89. PMID- 8647665 OWN - NLM STAT- completed DA - 19960719 DCOM- 19960719 LR - 20031114 IS - 0011-9059 VI - 34 IP - 12 DP - 1995 Dec TI - Pigmented eccrine poroma: a simulant of nodular melanoma. PG - 857-8 AD - Department of Dermatology, American University of Beirut Medical Center, Lebanon. FAU - Mousawi, A AU - Mousawi A FAU - Kibbi, A G AU - Kibbi AG LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Int J Dermatol JID - 0243704 SB - IM MH - Acrospiroma, Eccrine/*diagnosis/pathology MH - Aged MH - Diagnosis, Differential MH - Hand MH - Human MH - Male MH - Melanoma/*diagnosis MH - Skin Neoplasms/*diagnosis MH - Sweat Gland Neoplasms/*diagnosis/pathology EDAT- 1995/12/01 MHDA- 1995/12/01 00:01 PST - ppublish SO - Int J Dermatol 1995 Dec;34(12):857-8. PMID- 8599450 OWN - NLM STAT- completed DA - 19960424 DCOM- 19960424 LR - 20031114 IS - 0193-1091 VI - 17 IP - 5 DP - 1995 Oct TI - p53 protein and proliferating cell nuclear antigen in eccrine poroma and porocarcinoma. an immunohistochemical study. PG - 457-64 AB - The expression of p53 protein and proliferating cell nuclear antigen (PCNA) in 18 eccrine poromas and four porocarcinomas was examined by immunohistochemistry. Immunoreactivity for p53 in eccrine poromas was negative in five tumors, < 10% of tumor cells in one (low expresser), 10-50% in seven (moderate expressers), and > 50% in five (high expressers). The duration of the presence before excision of p53-negative poromas was shorter, and the size of these tumors was smaller in comparison with those of p53-positive poromas. Moreover, all high expressers showed some atypical cells in limited areas. Of the four porocarcinomas, three were high expressers and one a low expresser of p53 protein. The low-expresser tumor showed clinically more rapid growth and histologically no poromatous foci in contrast to the high expressers. No significant correlation was found between p53 protein expression and PCNA positive staining in either eccrine poromas or porocarcinomas. However, the percentages of PCNA-positive cells in porocarcinomas were significantly higher than those in poromas, with no overlapping values. These results suggest that the PCNA index is useful in differentiating between poroma and porocarcinoma and that p53 gene mutation may occur in long-standing eccrine poromas and correlate with atypical changes in histology as well as subsequent progression to porocarcinoma. AD - Department of Pathology, Nagoya City University Medical School, Japan. FAU - Tateyama, H AU - Tateyama H FAU - Eimoto, T AU - Eimoto T FAU - Tada, T AU - Tada T FAU - Inagaki, H AU - Inagaki H FAU - Nakamura, T AU - Nakamura T FAU - Yamauchi, R AU - Yamauchi R LA - eng PT - Journal Article PL - UNITED STATES TA - Am J Dermatopathol JID - 7911005 RN - 0 (Dyes) RN - 0 (Proliferating Cell Nuclear Antigen) RN - 0 (Protein p53) SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Adult MH - Aged MH - Aged, 80 and over MH - Comparative Study MH - Diagnosis, Differential MH - Disease Progression MH - Dyes/diagnostic use MH - Female MH - Gene Expression Regulation, Neoplastic MH - Genes, p53/genetics MH - Human MH - Immunohistochemistry MH - Male MH - Middle Aged MH - Mitosis MH - Mutation/genetics MH - Proliferating Cell Nuclear Antigen/*analysis/genetics MH - Protein p53/*analysis/genetics MH - Sweat Gland Neoplasms/*pathology EDAT- 1995/10/01 MHDA- 1995/10/01 00:01 PST - ppublish SO - Am J Dermatopathol 1995 Oct;17(5):457-64. PMID- 8586760 OWN - NLM STAT- completed DA - 19960322 DCOM- 19960322 LR - 20031114 IS - 0385-2407 VI - 22 IP - 10 DP - 1995 Oct TI - A single lesion demonstrating features of eccrine poroma and poroid hidradenoma. PG - 773-9 AB - A case of a single poroma lesion with the features of eccrine poroma and poroid hidradenoma is reported. The patient was a 61-year-old woman with a soft nodule, light brown in color, located on the posterior aspect of the right knee and containing a pigmented papular lesion in its center. The histological features of the papular lesion and the nodule were consistent with those of eccrine poroma and poroid hidradenoma, respectively. The eccrine poroma portion consisted mostly of poroid cells. The number of cuticular cells was slightly greater than that of poroid cells in the poroid hidradenoma portion. The cuticular cells in this portion as well as the poroid cells in both portions were immunohistochemically positive for epithelial membrane antigen. The findings in this case suggest that there is a close relationship between eccrine poroma and poroid hidradenoma and support the view that poroid hidradenoma is a type of poroma. AD - Department of Internal Medicine, Saga Medical School, Japan. FAU - Misago, N AU - Misago N FAU - Kohda, H AU - Kohda H LA - eng PT - Case Reports PT - Journal Article PL - JAPAN TA - J Dermatol JID - 7600545 RN - 0 (Antigens, Neoplasm) RN - 0 (CA-15-3 Antigen) RN - 0 (Neoplasm Proteins) SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Adenoma, Sweat Gland/*pathology MH - Antigens, Neoplasm/analysis MH - CA-15-3 Antigen/analysis MH - Female MH - Human MH - Immunohistochemistry MH - Knee/pathology MH - Middle Aged MH - Neoplasm Proteins/analysis MH - Neoplasms, Multiple Primary/*pathology MH - Pigmentation Disorders/pathology MH - Sweat Gland Neoplasms/*pathology EDAT- 1995/10/01 MHDA- 1995/10/01 00:01 PST - ppublish SO - J Dermatol 1995 Oct;22(10):773-9. PMID- 7562460 OWN - NLM STAT- completed DA - 19951114 DCOM- 19951114 LR - 20031114 IS - 8750-7315 VI - 85 IP - 9 DP - 1995 Sep TI - Eccrine poroma. A case report. PG - 500-1 AD - Podiatric Medicine Residency Training Program, Waco Veterans Affairs Medical Center, TX, USA. FAU - Hayes, S W AU - Hayes SW FAU - Derk, F F AU - Derk FF FAU - Nardozza, A J AU - Nardozza AJ LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - J Am Podiatr Med Assoc JID - 8501423 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Foot Diseases/*pathology MH - Human MH - Male MH - Middle Aged MH - Sweat Gland Neoplasms/*pathology EDAT- 1995/09/01 MHDA- 1995/09/01 00:01 PST - ppublish SO - J Am Podiatr Med Assoc 1995 Sep;85(9):500-1. PMID- 7498053 OWN - NLM STAT- completed DA - 19960118 DCOM- 19960118 LR - 20031114 IS - 0012-835X VI - 72 IP - 9 DP - 1995 Sep TI - Eccrine acrospiroma in a young African male: case report. PG - 613-4 AB - This is a report of a rare benign neoplasm of the sweat gland in a 23 year old African male. Clinically, the growth had the appearance of an ulcerated malignant cutaneous neoplasm. It was completely and easily excised at surgery and the patient has remained well without recurrence five years after complete excision. AD - Department of Surgery, Ahmadu Bello University Teaching Hospital Zaria, Nigeria. FAU - Nmadu, P T AU - Nmadu PT LA - eng PT - Case Reports PT - Journal Article PL - KENYA TA - East Afr Med J JID - 0372766 SB - IM MH - *Acrospiroma, Eccrine/pathology/surgery MH - Adult MH - Follow-Up Studies MH - Human MH - Male MH - Nigeria MH - *Sweat Gland Neoplasms/pathology/surgery EDAT- 1995/09/01 MHDA- 1995/09/01 00:01 PST - ppublish SO - East Afr Med J 1995 Sep;72(9):613-4. PMID- 7557914 OWN - NLM STAT- completed DA - 19951122 DCOM- 19951122 LR - 20031114 IS - 0309-0167 VI - 27 IP - 1 DP - 1995 Jul TI - Pigmented eccrine porocarcinoma: a mimic of malignant melanoma. PG - 86-8 AD - Division of Pathology, Aichi Medical University Hospital, Japan. FAU - Hara, K AU - Hara K FAU - Kamiya, S AU - Kamiya S LA - eng PT - Case Reports PT - Journal Article PL - ENGLAND TA - Histopathology JID - 7704136 RN - 0 (Melanins) RN - 0 (Tumor Markers, Biological) SB - IM MH - Acrospiroma, Eccrine/chemistry/*diagnosis/pathology MH - Aged MH - Dendritic Cells/chemistry MH - Diagnosis, Differential MH - Female MH - Human MH - Immunohistochemistry MH - Melanins/analysis MH - Melanocytes/chemistry MH - Melanoma/chemistry/*diagnosis/pathology MH - *Pigmentation MH - Skin Neoplasms/chemistry/*diagnosis/pathology MH - Sweat Gland Neoplasms/chemistry/*diagnosis/pathology MH - Tumor Markers, Biological/analysis EDAT- 1995/07/01 MHDA- 1995/07/01 00:01 PST - ppublish SO - Histopathology 1995 Jul;27(1):86-8. PMID- 7650246 OWN - NLM STAT- completed DA - 19950928 DCOM- 19950928 LR - 20031114 IS - 0385-2407 VI - 22 IP - 6 DP - 1995 Jun TI - A case of multiple eccrine porocarcinoma with stepping-stone distribution on the foot. PG - 450-7 AB - An 89-year-old woman had three tumors of several years' duration in a stepping-stone distribution on the dorsum of her right foot. The two larger ones were diagnosed histologically as eccrine porocarcinomas, and the smallest of the three shared many clinical similarities with them. Eccrine porocarcinoma is a rare malignant tumor. We describe this peculiar case in which three tumors developed in the same region and discuss how they might have occurred. It is most likely that the three tumors of this case originated from nevoid tumors, and that the individual lesions exhibited malignant changes. AD - Department of Dermatology, Yamaguchi Rosai Hospital, Japan. FAU - Ujihara, M AU - Ujihara M FAU - Hamanaka, S AU - Hamanaka S FAU - Hamanaka, Y AU - Hamanaka Y FAU - Kamei, T AU - Kamei T LA - eng PT - Case Reports PT - Journal Article PL - JAPAN TA - J Dermatol JID - 7600545 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - Aged, 80 and over MH - Cell Nucleus/ultrastructure MH - Cytoplasm/ultrastructure MH - Eccrine Glands/pathology MH - Female MH - Foot Diseases/*pathology MH - Human MH - Sweat Gland Neoplasms/*pathology EDAT- 1995/06/01 MHDA- 1995/06/01 00:01 PST - ppublish SO - J Dermatol 1995 Jun;22(6):450-7. PMID- 7790144 OWN - NLM STAT- completed DA - 19950727 DCOM- 19950727 LR - 20031114 IS - 0011-9059 VI - 34 IP - 4 DP - 1995 Apr TI - Malignant eccrine acrospiroma of the breast. PG - 271-3 AD - Department of Radiological Sciences, University of California, College of Medicine, Orange, Irvine 92668-3298, USA. FAU - Cyrlak, D AU - Cyrlak D FAU - Barr, R J AU - Barr RJ FAU - Wile, A G AU - Wile AG LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Int J Dermatol JID - 0243704 SB - IM MH - Acrospiroma, Eccrine/blood supply/*pathology MH - Adult MH - Biopsy MH - Breast Neoplasms/blood supply/*pathology MH - Cell Nucleus/ultrastructure MH - Endothelium, Vascular/pathology MH - Epidermis/pathology MH - Female MH - Human MH - Keratinocytes/pathology MH - Melanosis/pathology MH - Sweat Gland Neoplasms/blood supply/*pathology EDAT- 1995/04/01 MHDA- 1995/04/01 00:01 PST - ppublish SO - Int J Dermatol 1995 Apr;34(4):271-3. PMID- 7538986 OWN - NLM STAT- completed DA - 19950629 DCOM- 19950629 LR - 20031114 IS - 0017-8470 VI - 46 IP - 3 DP - 1995 Mar TI - [Multiple palmoplantar keratoses, basaliomas and porocarcinomas after arsenic therapy] PG - 198-201 AD - Hautklinik, Universitat Heidelberg. FAU - Junge, J AU - Junge J FAU - Moll, I AU - Moll I LA - ger PT - Case Reports PT - Journal Article TT - Multiple Palmoplantarkeratosen, Basaliome und Porokarzinome nach Arsen-Therapie. PL - GERMANY TA - Hautarzt JID - 0372755 RN - 0 (Arsenites) RN - 0 (Potassium Compounds) RN - 0 (Tumor Markers, Biological) RN - 1332-10-1 (potassium arsenite solution) RN - 68238-35-7 (Keratin) SB - IM MH - Acrospiroma, Eccrine/*chemically induced/pathology MH - Aged MH - Arsenites/administration & dosage/*adverse effects MH - Biopsy MH - Carcinoma, Basal Cell/*chemically induced/pathology MH - Diagnosis, Differential MH - English Abstract MH - Human MH - Keratin/analysis MH - Keratoderma, Palmoplantar/*chemically induced/pathology MH - Male MH - Neoplasms, Multiple Primary/*chemically induced/pathology MH - Potassium Compounds/administration & dosage/*adverse effects MH - Precancerous Conditions/*chemically induced/pathology MH - Skin/pathology MH - Skin Neoplasms/*chemically induced/pathology MH - Tumor Markers, Biological/analysis EDAT- 1995/03/01 MHDA- 1995/03/01 00:01 PST - ppublish SO - Hautarzt 1995 Mar;46(3):198-201. PMID- 7877107 OWN - NLM STAT- completed DA - 19950404 DCOM- 19950404 LR - 20031114 IS - 8750-7315 VI - 85 IP - 2 DP - 1995 Feb TI - Malignant eccrine acrospiroma. A case study. PG - 116-7 FAU - Kauderer, C AU - Kauderer C FAU - Clarke, H D AU - Clarke HD FAU - Fatone, C T AU - Fatone CT LA - eng PT - Case Reports PT - Letter PL - UNITED STATES TA - J Am Podiatr Med Assoc JID - 8501423 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Adult MH - Female MH - Foot Diseases/*pathology MH - Human MH - Sweat Gland Neoplasms/*pathology MH - Toes EDAT- 1995/02/01 MHDA- 1995/02/01 00:01 PST - ppublish SO - J Am Podiatr Med Assoc 1995 Feb;85(2):116-7. PMID- 7857121 OWN - NLM STAT- completed DA - 19950310 DCOM- 19950310 LR - 20031114 IS - 0003-987X VI - 131 IP - 2 DP - 1995 Feb TI - Pedal papule. Eccrine porocarcinoma (EPC) in association with poroma. PG - 211, 214 AD - Ohio State University, Columbus. FAU - Spencer, D M AU - Spencer DM FAU - Bigler, L R AU - Bigler LR FAU - Hearne, D W AU - Hearne DW FAU - Davis, L S AU - Davis LS FAU - Pellegrini, A AU - Pellegrini A LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Arch Dermatol JID - 0372433 SB - AIM SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Female MH - Foot Diseases/*pathology MH - Human MH - Middle Aged MH - Sweat Gland Neoplasms/*pathology EDAT- 1995/02/01 MHDA- 1995/02/01 00:01 PST - ppublish SO - Arch Dermatol 1995 Feb;131(2):211, 214. PMID- 7894103 OWN - NLM STAT- completed DA - 19950425 DCOM- 19950425 LR - 20031114 IS - 1018-8665 VI - 190 IP - 1 DP - 1995 TI - Malignant hidroacanthoma simplex. A case report and literature review. PG - 72-6 AB - A 73-year-old woman with a malignant hidroacanthoma simplex on her right lower limb is reported. The lesion was immunohistochemically studied. Carcino-embryonic antigen and epithelial membrane antigen were found in the luminal border of ductal structures within the aggregations of neoplastic cells. We review the literature on this subject. AD - Department of Dermatology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain. FAU - Pique, E AU - Pique E FAU - Olivares, M AU - Olivares M FAU - Espinel, M L AU - Espinel ML FAU - Farina, M AU - Farina M FAU - Martin, L AU - Martin L FAU - Barat, A AU - Barat A FAU - Requena, L AU - Requena L FAU - Castro, A AU - Castro A LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review of Reported Cases PL - SWITZERLAND TA - Dermatology JID - 9203244 SB - IM MH - Acrospiroma, Eccrine/immunology/*pathology/ultrastructure MH - Aged MH - Female MH - Human MH - Immunohistochemistry MH - Leg MH - Sweat Gland Neoplasms/immunology/*pathology/ultrastructure RF - 20 EDAT- 1995/01/01 MHDA- 1995/01/01 00:01 PST - ppublish SO - Dermatology 1995;190(1):72-6. PMID- 7671392 OWN - NLM STAT- completed DA - 19951019 DCOM- 19951019 LR - 20001218 IS - 0307-6938 VI - 20 IP - 1 DP - 1995 Jan TI - Assessment of cellular proliferation of eccrine acrospiromas and eccrine sweat gland carcinomas by AgNOR counting and immunohistochemical demonstration of proliferating cell nuclear antigen (PCNA) and Ki-67. PG - 27-34 AB - Argyrophil nucleolar organizer regions (AgNORs) were counted and immunostaining using antibodies raised against proliferating cell nuclear antigen (PCNA) and Ki-67 was carried out on eccrine acrospiroma and eccrine sweat gland carcinoma, to determine the malignant potential and prognosis of these tumours. Formalin-fixed and paraffin-embedded tissue specimens surgically excised from 25 patients with eccrine sweat gland carcinoma (20 cases of eccrine porocarcinoma, four cases of ductal sweat gland carcinoma and one case of malignant clear cell hidradenoma) and 25 patients with eccrine acrospiroma (16 cases of eccrine poroma, four cases of poroid hidradenoma and five cases of clear cell hidradenoma) were used. PCNA and Ki-67 labelling indices were categorized semiquantitatively into four grades. Significant differences were noted between eccrine sweat gland carcinoma and eccrine acrospiroma with these three methods (P < 0.01). When a cut-off of 5 was chosen, the AgNOR value distinguished eccrine sweat gland carcinoma from eccrine acrospiroma with high specificity and sensitivity. Moreover, we compared the results of these three methods between stages 1 or 2 (17 cases) and stage 3 (eight cases) eccrine sweat gland carcinomas, and no significant differences were observed. From these findings, these three methods are useful in discriminating malignant from benign lesions of eccrine tumours, but have no value in estimating the aggressiveness of eccrine sweat gland carcinomas. AD - Department of Dermatology, Yamagata University School of Medicine, Japan. FAU - Ansai, S AU - Ansai S FAU - Koseki, S AU - Koseki S FAU - Hozumi, Y AU - Hozumi Y FAU - Kondo, S AU - Kondo S LA - eng PT - Journal Article PL - ENGLAND TA - Clin Exp Dermatol JID - 7606847 RN - 0 (Ki-67 Antigen) RN - 0 (Neoplasm Proteins) RN - 0 (Nuclear Proteins) RN - 0 (Proliferating Cell Nuclear Antigen) SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Adenocarcinoma/*pathology MH - Cell Division MH - Human MH - Ki-67 Antigen MH - Neoplasm Proteins/analysis MH - Nuclear Proteins/analysis MH - Nucleolus Organizer Region/*pathology MH - Proliferating Cell Nuclear Antigen/analysis MH - Sweat Gland Neoplasms/*pathology EDAT- 1995/01/01 MHDA- 1995/01/01 00:01 PST - ppublish SO - Clin Exp Dermatol 1995 Jan;20(1):27-34. PMID- 7541147 OWN - NLM STAT- completed DA - 19950803 DCOM- 19950803 LR - 20021101 IS - 0080-0015 VI - 139 DP - 1995 TI - Immunohistochemistry of eccrine poroma and porocarcinoma--more than acrosyringeal tumors? PG - 303-16 AB - Sweat gland tumors have been classified according to their presumed physiological counterpart of the sweat apparatus. Both benign poroma and malignant porocarcinoma are thought to be acrosyringeal tumors. In order to specify this general assumption, we performed histochemistry and immunohistochemistry on paraffin sections of 29 poromas and eight porocarcinomas. In detail, we used Lapham's stain, Masson's silver impregnation, and immunoperoxidase staining with glandular marker antibodies against glycoproteins (CEA, LS59, NKI/C-3) and intermediate filament proteins (wide spectrum keratin, Cam 5.2, Vim 9(1)). Poromas disclosed some scattered S100-positive dendritic cells, red-stained cells in Lapham's method, several silver impregnated dendritic cells, and numerous cells surrounding poromas which were positive for LS59 and NKI/C-3. The labeling with wide spectrum keratin antiserum was low compared to epidermal keratinocytes. Porocarcinomas made some difference. CEA-positive single vacuolated cells could be observed, and S100-positive cells failed to show dendrites as in poromas. Some tumor cell clusters were stained weakly with LS59 and NKI/C-3 in addition to surrounding cells in both tumor entities. Three out of eight porocarcinomas disclosed sparsely distributed scattered cells weakly reactive with antibodies Cam 5.2 or Vim 9(1). In general, malignant porocarcinomas expressed a greater variety of cellular markers than benign poromas. The differentiation of both tumors, however, was directed toward inner duct cells and myoepithelium. Since myoepithelial cells are missing in normal acrosyringium, poromas and porocarcinomas are thought to be sweat gland tumors related to the distal portion of the dermal duct. AD - Department of Dermatology, Friedrich Schiller University of Jena, Germany. FAU - Wollina, U AU - Wollina U FAU - Castelli, E AU - Castelli E FAU - Rulke, D AU - Rulke D LA - eng PT - Journal Article PL - GERMANY TA - Recent Results Cancer Res JID - 0044671 RN - 0 (Antigens, Neoplasm) RN - 0 (Carcinoembryonic Antigen) RN - 0 (Neoplasm Proteins) RN - 0 (S100 Proteins) RN - 0 (Tumor Markers, Biological) RN - 0 (Vimentin) RN - 68238-35-7 (Keratin) SB - IM MH - Acrospiroma, Eccrine/*chemistry/pathology MH - Antigens, Neoplasm/analysis MH - Carcinoembryonic Antigen/analysis MH - Cell Differentiation MH - Human MH - Immunohistochemistry MH - Keratin/analysis MH - Neoplasm Proteins/*analysis MH - S100 Proteins/analysis MH - Support, Non-U.S. Gov't MH - Sweat Gland Neoplasms/*chemistry/pathology MH - Tumor Markers, Biological/*analysis MH - Vimentin/analysis EDAT- 1995/01/01 MHDA- 1995/01/01 00:01 PST - ppublish SO - Recent Results Cancer Res 1995;139:303-16. PMID- 7868774 OWN - NLM STAT- completed DA - 19950328 DCOM- 19950328 LR - 20031114 IS - 0385-2407 VI - 21 IP - 12 DP - 1994 Dec TI - Calcification of eccrine poroma. PG - 979-81 AB - Two cases of eccrine poroma with calcification were described, both of which were those of the Winkelmann-MacLeod type. They occurred on the face and lower leg. We supposed that calcification in both cases was dystrophic in nature due to minor pressure or injury. The feature of calcification within the nests of eccrine poroma has rarely been reported. However, it seemed to be physiologically consistant that calcification occurs in eccrine poroma which originates from eccrine sweat glands. AD - Department of Dermatology, Tokyo Medical and Dental University School of Medicine, Japan. FAU - Yamamoto, T AU - Yamamoto T FAU - Irifune, A AU - Irifune A FAU - Katayama, I AU - Katayama I FAU - Nishioka, K AU - Nishioka K LA - eng PT - Case Reports PT - Journal Article PL - JAPAN TA - J Dermatol JID - 7600545 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - Calcinosis/*pathology MH - Female MH - Human MH - Male MH - Middle Aged MH - Sweat Gland Neoplasms/*pathology EDAT- 1994/12/01 MHDA- 1994/12/01 00:01 PST - ppublish SO - J Dermatol 1994 Dec;21(12):979-81. PMID- 7798408 OWN - NLM STAT- completed DA - 19950123 DCOM- 19950123 LR - 20031114 IS - 0148-0812 VI - 20 IP - 12 DP - 1994 Dec TI - Stump the experts. Eccrine acrospiroma. PG - 787, 845 AD - Department of Dermatology, Cleveland Clinic Foundation, OH 44195. FAU - Marsico, R AU - Marsico R FAU - Narurkar, V AU - Narurkar V FAU - Helm, T N AU - Helm TN LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - J Dermatol Surg Oncol JID - 7707501 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Axilla MH - Cytoplasm/ultrastructure MH - Diagnosis, Differential MH - Epithelium/pathology MH - Human MH - Male MH - Middle Aged MH - Skin Neoplasms/*pathology EDAT- 1994/12/01 MHDA- 1994/12/01 00:01 PST - ppublish SO - J Dermatol Surg Oncol 1994 Dec;20(12):787, 845. PMID- 7923079 OWN - NLM STAT- completed DA - 19941116 DCOM- 19941116 LR - 20031114 IS - 0165-4608 VI - 77 IP - 1 DP - 1994 Oct TI - Cytogenetic heterogeneity in a clear cell hidradenoma of the skin. PG - 26-32 AB - Short-term cultures from a clear cell hidradenoma, a benign skin tumor for which no chromosome data exist, were cytogenetically analyzed. A total of eight unrelated aberrant clones were identified. The karyotypic profiles of two separately processed parts of the sample--a tumor nodule and seemingly normal adjacent dermal tissue--were different. Characteristic for the tumor nodule was a single abnormal clonal population consisting of three subclones: 46,XY,der(2)inv(2)(p13q23)t(2;9)(p13;q22), der(9)t(2;9)(q23;q22),t(11;19)(q21;p13),t(12;19)(q24;p13)/46,idem, inv(1)(p32q44)/92,idemx2. The adjacent tissue contained, in addition to the clone found in the tumor nodule, a spectrum of unrelated clones, the largest of which also showed clonal evolution: 45-47,XY,t(3;6)(p25;p25),t(12;17)(q15;q12),-17,+r(17)x2 [cp]/45-47,idem,inv(5)(p15q22)/90-94,idemx2. The remaining six clones found in this part were small and had simpler numerical or structural aberrations. The multiclonal pattern observed in this hidradenoma seems to reflect both cytogenetic convergence and divergence during neoplastic progression. The presence of unrelated clones may be an indication that the tumor was of multicellular origin. AD - Department of Clinical Genetics, University Hospital, Lund, Sweden. FAU - Gorunova, L AU - Gorunova L FAU - Mertens, F AU - Mertens F FAU - Mandahl, N AU - Mandahl N FAU - Jonsson, N AU - Jonsson N FAU - Persson, B AU - Persson B FAU - Heim, S AU - Heim S FAU - Mitelman, F AU - Mitelman F LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Cancer Genet Cytogenet JID - 7909240 SB - IM MH - Acrospiroma, Eccrine/*genetics/pathology MH - Aged MH - *Chromosome Aberrations MH - Human MH - Karyotyping MH - Male MH - Skin Neoplasms/*genetics/pathology MH - Support, Non-U.S. Gov't EDAT- 1994/10/01 MHDA- 1994/10/01 00:01 PST - ppublish SO - Cancer Genet Cytogenet 1994 Oct;77(1):26-32. PMID- 7960742 OWN - NLM STAT- completed DA - 19941221 DCOM- 19941221 LR - 20031114 IS - 1043-3074 VI - 16 IP - 5 DP - 1994 Sep-Oct TI - Malignant clear cell hidradenoma of the upper lip. PG - 443-9 AB - Malignant clear cell hidradenoma is an uncommon tumor of eccrine sweat gland origin that has a predilection for the head and neck. It is characterized by an indolent growth pattern yet frequently recurs following surgical excision and has a high incidence of regional and distant metastases. A case of recurrent malignant clear cell hidradenoma of the upper lip is presented. The lesion was treated with surgical excision followed by radiotherapy. The literature on this rare lesion is reviewed and treatment strategies discussed. AD - Division of Head and Neck Surgery, UCLA Medical Center. FAU - Orlandi, R R AU - Orlandi RR FAU - Sercarz, J A AU - Sercarz JA FAU - Doberneck, S A AU - Doberneck SA FAU - Calcaterra, T C AU - Calcaterra TC LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review of Reported Cases PL - UNITED STATES TA - Head Neck JID - 8902541 SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - Combined Modality Therapy MH - Follow-Up Studies MH - Human MH - Lip Neoplasms/*pathology MH - Male MH - Neoplasm Invasiveness MH - Neoplasm Recurrence, Local/pathology MH - Nose Neoplasms/*pathology RF - 32 EDAT- 1994/09/01 MHDA- 1994/09/01 00:01 PST - ppublish SO - Head Neck 1994 Sep-Oct;16(5):443-9. PMID- 7849675 OWN - NLM STAT- completed DA - 19950316 DCOM- 19950316 LR - 20031114 IS - 1067-2516 VI - 33 IP - 5 DP - 1994 Sep-Oct TI - Malignant eccrine neoplasms of the foot. PG - 486-91 AB - Eccrine cancers are uncommon, but potentially recurrent, metastatic and fatal. Rarely, they are primary foot lesions. The literature records 46 foot cases, with age and sex given for 41. Various eccrine cancer types (most on the sole), affected all races, males predominating. Average age at diagnosis was approximately 55. A podiatric facility recorded eight cases among approximately 30,000 skin biopsies, during 15 years. Seven arose in women. Five arose in the great toe area. Three are porocarcinomas. Five are "adenocarcinomas" varying in degree of differentiation. None of the eight patients presented recurrence or metastasis during follow-up 0.5-13.4 years. Of the combined 49 literature and podiatric cases, 28 (57.1%) arose in men, mostly between ages 41 and 70. Most were slow growing, long standing, and mildly symptomatic. No clinical features distinguished eccrine cancers from other pedal tumors. AD - Maryland Podiatric Residency Program, Bon Secours Hospital, Baltimore, Maryland. FAU - Pontone, M AU - Pontone M FAU - Potter, G K AU - Potter GK FAU - Berlin, S J AU - Berlin SJ FAU - Reiss, P A AU - Reiss PA FAU - Levin, R S AU - Levin RS FAU - Mantell, G M AU - Mantell GM FAU - Gleitman, D AU - Gleitman D FAU - Kennelty, J M AU - Kennelty JM FAU - Simon, S D AU - Simon SD FAU - Kahn, J B AU - Kahn JB AU - et al. LA - eng PT - Journal Article PT - Review PT - Review, Tutorial PL - UNITED STATES TA - J Foot Ankle Surg JID - 9308427 SB - IM MH - Acrospiroma, Eccrine/epidemiology/pathology MH - Adenocarcinoma/epidemiology/pathology/secondary MH - Adenocarcinoma, Papillary/epidemiology/pathology/secondary MH - Adult MH - Age Factors MH - Aged MH - Aged, 80 and over MH - Baltimore/epidemiology MH - Eccrine Glands/*pathology MH - Female MH - Follow-Up Studies MH - Foot Diseases/*epidemiology/pathology MH - Human MH - Male MH - Middle Aged MH - Neoplasm Recurrence, Local/pathology MH - Sex Factors MH - Sweat Gland Neoplasms/*epidemiology/pathology RF - 47 EDAT- 1994/09/01 MHDA- 1994/09/01 00:01 PST - ppublish SO - J Foot Ankle Surg 1994 Sep-Oct;33(5):486-91. PMID- 7813238 OWN - NLM STAT- completed DA - 19950203 DCOM- 19950203 LR - 20031114 IS - 0011-4162 VI - 54 IP - 3 DP - 1994 Sep TI - Eccrine poroma in an unusual location. PG - 183-4 AD - Department of Dermatology, State University of New York at Buffalo 14203. FAU - Kircik, L AU - Kircik L FAU - Armus, S AU - Armus S FAU - Kipping, H AU - Kipping H FAU - Pincus, S H AU - Pincus SH LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Cutis JID - 0006440 SB - IM MH - Acrospiroma, Eccrine/*pathology/surgery MH - Adult MH - Breast MH - Female MH - Human MH - Pregnancy MH - *Pregnancy Complications, Neoplastic MH - Sweat Gland Neoplasms/*pathology/surgery EDAT- 1994/09/01 MHDA- 1994/09/01 00:01 PST - ppublish SO - Cutis 1994 Sep;54(3):183-4. PMID- 7525677 OWN - NLM STAT- completed DA - 19941206 DCOM- 19941206 LR - 20001218 IS - 0385-2407 VI - 21 IP - 8 DP - 1994 Aug TI - An immunohistochemical study of sebaceous carcinoma with anti-keratin monoclonal antibodies: comparison with other skin cancers. PG - 553-9 AB - Formalin-fixed and paraffin-embedded tissue specimens of six cases of extraocular sebaceous carcinoma were studied immunohistochemically with eight anti-keratin monoclonal antibodies, 34 beta B4, 35 beta H11, Ks13.1, Ks19.1, PKK1, LP34, KL1 and AE1. The staining patterns of sebaceous carcinoma were compared with those of normal sebaceous glands and other skin cancers which should be distinguished from sebaceous carcinoma histopathologically. The other skin cancers compared were eccrine porocarcinoma, malignant clear cell hidradenoma, extramammary Paget's disease with underlying adenocarcinoma, malignant trichilemmoma, and squamous cell carcinoma. Most cases of sebaceous carcinoma were stained with 35 beta H11, Ks19.1, LP34, KL1 and AE1, while normal sebaceous glands were positive only with 35 beta H11, LP34, KL1 and AE1. By immunostaining, sebaceous carcinoma was distinguishable from extramammary Paget's disease with underlying adenocarcinoma, squamous cell carcinoma, malignant trichilemmoma, and eccrine porocarcinoma, but was not clearly distinguishable from malignant clear cell hidradenoma. These findings demonstrate that sebaceous carcinoma shows positive reactions with antibodies to simple epithelial keratin, probably as a result of neoplastic transformation, and that immunohistochemical examination using anti-keratin monoclonal antibodies is useful in distinguishing sebaceous carcinoma from several other skin cancers. AD - Department of Dermatology, Yamagata University, Faculty of Medicine, Japan. FAU - Ansai, S AU - Ansai S FAU - Katagata, Y AU - Katagata Y FAU - Yoshikawa, K AU - Yoshikawa K FAU - Hashimoto, H AU - Hashimoto H FAU - Hozumi, Y AU - Hozumi Y FAU - Kondo, S AU - Kondo S FAU - Aso, K AU - Aso K LA - eng PT - Journal Article PL - JAPAN TA - J Dermatol JID - 7600545 RN - 0 (Antibodies, Monoclonal) RN - 68238-35-7 (Keratin) SB - IM MH - Acrospiroma, Eccrine/chemistry MH - Adenocarcinoma, Sebaceous/*chemistry MH - Antibodies, Monoclonal MH - Carcinoma, Squamous Cell/chemistry MH - Comparative Study MH - Human MH - Immunohistochemistry MH - Keratin/*analysis/immunology MH - Neoplasms, Basal Cell/chemistry MH - Paget's Disease, Extramammary/chemistry MH - Sebaceous Gland Neoplasms/*chemistry MH - Skin Neoplasms/*chemistry MH - Support, Non-U.S. Gov't MH - Sweat Gland Neoplasms/chemistry EDAT- 1994/08/01 MHDA- 1994/08/01 00:01 PST - ppublish SO - J Dermatol 1994 Aug;21(8):553-9. PMID- 8024281 OWN - NLM STAT- completed DA - 19940802 DCOM- 19940802 LR - 20031114 IS - 0003-987X VI - 130 IP - 7 DP - 1994 Jul TI - Pigmented lesion on the back. Pigmented hidroacanthoma simplex (HS) (intraepidermal acrospiroma). PG - 914-5, 917 AD - Hospital Universitario San Carlos, Madrid, Spain. FAU - Velez, A AU - Velez A FAU - del Rio, E AU - del Rio E FAU - Martin, N AU - Martin N FAU - Sanchez Yus, E AU - Sanchez Yus E LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Arch Dermatol JID - 0372433 SB - AIM SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - Back MH - Human MH - Male MH - Sweat Gland Neoplasms/*pathology EDAT- 1994/07/01 MHDA- 1994/07/01 00:01 PST - ppublish SO - Arch Dermatol 1994 Jul;130(7):914-5, 917. PMID- 8159010 OWN - NLM STAT- completed DA - 19940518 DCOM- 19940518 LR - 20031114 IS - 0022-4790 VI - 55 IP - 4 DP - 1994 Apr TI - Eccrine porocarcinoma. PG - 261-4 AB - Eccrine porocarcinoma, a malignancy of the eccrine sweat glands, is extremely rare. Our report and a review of the literature (70 cases) emphasize the features of this tumor. Age at time of treatment ranged from 19 to 94 years (mean 67 years). Duration of the lesion ranged from two months to 50 years; 31 (44%) had the lesion present > or = 5 years. Forty-four patients (62%) had tumors located on the extremities, 13 (19%) on the head and neck region and 12 (17%) on the trunk. All patients whose race is known were white. Primary treatment should consist of wide local excision and regional lymphadenectomy, if clinically indicated. Although there is a significant risk of cutaneous, regional lymph node, or visceral metastases, the value of elective or therapeutic regional lymphadenectomy is unknown, as is the role of adjunctive therapy. AD - Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263. FAU - Goedde, T A AU - Goedde TA FAU - Bumpers, H AU - Bumpers H FAU - Fiscella, J AU - Fiscella J FAU - Rao, U AU - Rao U FAU - Karakousis, C P AU - Karakousis CP LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - J Surg Oncol JID - 0222643 SB - IM MH - *Acrospiroma, Eccrine/pathology MH - Aged MH - Aged, 80 and over MH - Groin MH - Human MH - Male MH - *Sweat Gland Neoplasms/pathology EDAT- 1994/04/01 MHDA- 1994/04/01 00:01 PST - ppublish SO - J Surg Oncol 1994 Apr;55(4):261-4. PMID- 7512801 OWN - NLM STAT- completed DA - 19940519 DCOM- 19940519 LR - 20031114 IS - 0193-1091 VI - 16 IP - 1 DP - 1994 Feb TI - Three subtypes of poroid neoplasia in a single lesion: eccrine poroma, hidroacanthoma simplex, and dermal duct tumor. Histologic, histochemical, and ultrastructural findings. PG - 66-72 AB - A single poroid neoplasm composed of three histologically distinct lesions (hidroacanthomas simplex, eccrine poroma, and dermal duct tumor) is reported. Comparative histologic, histochemical, and electron-microscopic studies revealed that each tumor subtype contained varying proportions of poroid cells, clear cells, and cuticular cells. The major component of all three neoplasms was poroid cells, which, under the electron microscope, were characterized by a few, small, poorly developed desmosomes, and were histochemically characterized by a positive succinic dehydrogenase reaction. The dermal duct tumor was cultured, and showed similar histochemical findings to the in vivo poroid cells. These results suggest that poroid cells play the most important role in the histogenesis of these three neoplasms. AD - Department of Dermatology, Surugadai Hospital, Nihon University, Tokyo, Japan. FAU - Kakinuma, H AU - Kakinuma H FAU - Miyamoto, R AU - Miyamoto R FAU - Iwasawa, U AU - Iwasawa U FAU - Baba, S AU - Baba S FAU - Suzuki, H AU - Suzuki H LA - eng PT - Case Reports PT - Journal Article PL - UNITED STATES TA - Am J Dermatopathol JID - 7911005 RN - 68238-35-7 (Keratin) RN - 9005-79-2 (Glycogen) SB - IM MH - Acrospiroma, Eccrine/chemistry/*pathology/ultrastructure MH - Aged MH - Cytoplasm/ultrastructure MH - Cytoplasmic Granules/ultrastructure MH - Epidermis/pathology MH - Glycogen/analysis MH - Human MH - Keratin/analysis MH - Male MH - Microscopy, Electron MH - Neoplasms, Glandular and Epithelial/chemistry/*pathology/ultrastructure MH - Neoplasms, Multiple Primary/chemistry/*pathology/ultrastructure MH - Skin Neoplasms/chemistry/*pathology/ultrastructure MH - Sweat Gland Neoplasms/chemistry/*pathology/ultrastructure MH - Tumor Cells, Cultured EDAT- 1994/02/01 MHDA- 1994/02/01 00:01 PST - ppublish SO - Am J Dermatopathol 1994 Feb;16(1):66-72. PMID- 7520572 OWN - NLM STAT- completed DA - 19940916 DCOM- 19940916 LR - 20040109 IS - 0344-0338 VI - 190 IP - 1 DP - 1994 Jan TI - Expression of keratin 20 in malignant eccrine poromas. PG - 11-4 AB - Eight cases of malignant eccrine poromas were studied immunohistochemically with a broad panel of antibodies in order to better characterise the spectrum of their differentiating pathways. Special attention was paid to the expression of cytokeratins, mainly the newly recognised keratin 20. In general, the pattern of staining agreed to previous studies. Anyway, a non-expected positivity with keratin 20 was seen in two cases. The usefulness of the immunohistochemistry to discover areas with masked differentiation in adnexal tumours of the skin was once more confirmed. AD - Department of Pathology, Hospital 12 de Octubre Complutensis University, Madrid, Spain. FAU - Ballestin, C AU - Ballestin C FAU - Nevado, M AU - Nevado M FAU - Gil-Martin, R AU - Gil-Martin R FAU - Sanz-Anquela, M AU - Sanz-Anquela M FAU - Lopez, J I AU - Lopez JI LA - eng PT - Journal Article PL - GERMANY TA - Pathol Res Pract JID - 7806109 RN - 0 (Intermediate Filament Proteins) RN - 0 (KRT20 protein, human) RN - 68238-35-7 (Keratin) SB - IM MH - Acrospiroma, Eccrine/*metabolism/pathology MH - Aged MH - Aged, 80 and over MH - Female MH - Human MH - Immunohistochemistry/methods MH - Intermediate Filament Proteins/*metabolism MH - Keratin/metabolism MH - Male MH - Middle Aged MH - Skin Neoplasms/*metabolism/pathology MH - Staining and Labeling EDAT- 1994/01/01 MHDA- 1994/01/01 00:01 PST - ppublish SO - Pathol Res Pract 1994 Jan;190(1):11-4. PMID- 7694517 OWN - NLM STAT- completed DA - 19931216 DCOM- 19931216 LR - 20031114 IS - 0193-1091 VI - 15 IP - 5 DP - 1993 Oct TI - Squamous differentiation in malignant eccrine poroma. PG - 492-6 AB - Squamous differentiation in poral adnexal neoplasms is a rare event. Two cases are presented of malignant eccrine poroma in which areas of squamous differentiation showing the features of squamous cell carcinoma were present. The areas of squamous differentiation were found within the invasive components of the lesions and appeared to result from direct transformation of the poral epithelial cells. A review of the literature on this unusual phenomenon is presented. AD - Arkadi M. Rywlin Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140. FAU - Pena, J AU - Pena J FAU - Suster, S AU - Suster S LA - eng PT - Case Reports PT - Journal Article PT - Review PT - Review, Tutorial PL - UNITED STATES TA - Am J Dermatopathol JID - 7911005 RN - 0 (keratohyalin) RN - 68238-35-7 (Keratin) SB - IM MH - Acrospiroma, Eccrine/*pathology MH - Aged MH - Aged, 80 and over MH - Carcinoma, Squamous Cell/*pathology MH - Cell Nucleus/ultrastructure MH - Cell Transformation, Neoplastic/pathology MH - Cytoplasm/ultrastructure MH - Cytoplasmic Granules/ultrastructure MH - Foot Diseases/pathology MH - Human MH - Hyalin MH - Keratin MH - Keratinocytes/pathology MH - Male MH - Neoplasm Invasiveness MH - Sweat Gland Neoplasms/*pathology MH - Thigh RF - 11 EDAT- 1993/10/01 MHDA- 1993/10/01 00:01 PST - ppublish SO - Am J Dermatopathol 1993 Oct;15(5):492-6. PMID- 7693778 OWN - NLM STAT- completed DA - 19931203 DCOM- 19931203 LR - 20021101 IS - 0303-6987 VI - 20 IP - 4 DP - 1993 Aug TI - Sweat gland adenomas: immunohistochemical study with emphasis on myoepithelial differentiation. PG - 337-43 AB - Thirty-one dermal appendage tumors of sweat gland differentiation including 7 spiradenomas (SPA), 8 cylindromas (CYL), 8 acrospiromas (ACS), and 8 chondroid syringomas (CS) were analyzed using antibodies to epithelial membrane antigen (EMA), cytokeratin (AE1, AE3, CAM 5.2, 34BE12), S-100 protein, actin (ACT), and desmin (DES) to characterize the immunocytochemical profile of benign sweat gland tumors. Cytokeratin expression was variable; AE1, 34BE12, AE3, and CAM 5.2 were present in 31, 24, 23, and 22 tumors respectively; 29 tumors contained EMA. Seventeen tumors, (6 SPA, 8 CYL, 2 ACS, 1 CS) stained with antibody to alpha smooth muscle actin, and 26 (7 SPA, 7 CYL, 4 ACS, 8 CS) expressed S-100 protein. Although some prior studies had reported actin filaments on electron microscopy in both spiradenoma and cylindroma, these tumors have previously been considered to be negative for myoepithelial differentiation. All spiradenomas and cylindromas we studied demonstrated actin and/or S-100 protein positivity in basal epithelial cells, consistent with myoepithelial differentiation. The organization of actin and S-100 protein positivity displayed by the spiradenomas and cylindromas we studied suggests that the tumors are differentiated towards the secretory portion of the eccrine sweat gland. AD - Department of Pathology, University of Texas, Southwestern Medical Center at Dallas 75235-9072. FAU - Wiley, E L AU - Wiley EL FAU - Milchgrub, S AU - Milchgrub S FAU - Freeman, R G AU - Freeman RG FAU - Kim, E S AU - Kim ES LA - eng PT - Journal Article PL - DENMARK TA - J Cutan Pathol JID - 0425124 RN - 0 (Actins) RN - 0 (CA-15-3 Antigen) RN - 0 (Desmin) RN - 0 (Immune Sera) RN - 0 (Membrane Glycoproteins) RN - 0 (S100 Proteins) RN - 68238-35-7 (Keratin) SB - IM MH - Acrospiroma, Eccrine/chemistry/pathology MH - Actins/analysis/immunology MH - Adenoma, Sweat Gland/chemistry/*pathology MH - CA-15-3 Antigen MH - Cell Transformation, Neoplastic/*pathology MH - Desmin/analysis/immunology MH - Epithelium/pathology MH - Human MH - Immune Sera/immunology MH - Immunohistochemistry MH - Keratin/analysis/immunology MH - Membrane Glycoproteins/analysis/immunology MH - S100 Proteins/analysis/immunology MH - Sweat Gland Neoplasms/chemistry/*pathology MH - Syringoma/chemistry/pathology EDAT- 1993/08/01 MHDA- 1993/08/01 00:01 PST - ppublish SO - J Cutan Pathol 1993 Aug;20(4):337-43.